Results 21 to 30 of about 20,078 (221)

The Mycobacterium tuberculosis Phagosome [PDF]

, 2008
Tuberculosis is currently the most devastating human bacterial disease, causing millions of deaths annually and infecting an overwhelming percentage of the global population. Its success as a scourge lies in the ability of Mycobacterium tuberculosis to prevent normal phagolysosome biogenesis, essential to the destruction of invading microorganisms ...
Esteban A, Roberts, Vojo, Deretic
openaire   +2 more sources

TRPC6 channel translocation into phagosomal membrane augments phagosomal function [PDF]

Proceedings of the National Academy of Sciences, 2015
SignificanceHistorically, pulmonary infections treated with antibiotics killed bacteria while selecting for the unintended development of pathogenic resistance. One strategy to circumvent antibiotic resistance in pulmonary infection involves targeting the host phagosome and augmenting its function.
Riazanski, Vladimir, Gabdoulkhakova, Aida G., Boynton, Lin S., Eguchi, Raphael R., Deriy, Ludmila V., Hogarth, D. Kyle, Loaëc, Nadège, Oumata, Nassima, Galons, Hervé, Brown, Mary E., Shevchenko, Pavel, Gallan, Alexander J., Yoo, Sang Gune, Naren, Anjaparavanda P., Villereal, Mitchel L., Beacham, Daniel W., Bindokas, Vytautas P., Birnbaumer, Lutz, Meijer, Laurent, Nelson, Deborah J.   +19 more
openaire   +3 more sources

SWAP70 Organizes the Actin Cytoskeleton and Is Essential for Phagocytosis

Cell Reports, 2016
Actin plays a critical role during the early stages of pathogenic microbe internalization by immune cells. In this study, we identified a key mechanism of actin filament tethering and stabilization to the surface of phagosomes in human dendritic cells ...
Maksim V. Baranov, Natalia H. Revelo, Ilse Dingjan, Riccardo Maraspini, Martin ter Beest, Alf Honigmann, Geert van den Bogaart   +6 more
doaj   +1 more source

Analysis of phagosomal proteomes: From latex‐bead to bacterial phagosomes [PDF]

PROTEOMICS, 2010
Abstract Phagosomal proteome characterization has contributed significantly to the understanding of host–pathogen interaction and the mechanism of infectious diseases caused by intracellular bacteria. The latex bead‐containing phagosome has been widely used as a model system to study phagosomal proteomes at a global level. In contrast,
Qingbo, Li, Chinnaswamy, Jagannath, Prahlad K, Rao, Christopher R, Singh, Giovanni, Lostumbo   +4 more
openaire   +2 more sources

Two PI 3-kinases and one PI 3-phosphatase together establish the cyclic waves of phagosomal PtdIns(3)P critical for the degradation of apoptotic cells. [PDF]

PLoS Biology, 2012
Phosphatidylinositol 3-phosphate (PtdIns(3)P) is a signaling molecule important for many membrane trafficking events, including phagosome maturation. The level of PtdIns(3)P on phagosomes oscillates in two waves during phagosome maturation.
Nan Lu, Qian Shen, Timothy R Mahoney, Lukas J Neukomm, Ying Wang, Zheng Zhou   +5 more
doaj   +1 more source

The macrophage marches on its phagosome: dynamic assays of phagosome function [PDF]

Nature Reviews Immunology, 2009
Professional phagocytes ingest particulate material to fulfil a diverse array of functions in a multicellular organism. The ancestral function of phagosomes is digestion; however, through evolution this degradative capacity has become pivotal to the adaptive immune response by processing antigens to be presented to lymphocytes.
Russell, David G, Vanderven, Brian C, Glennie, S, Mwandumba, Henry C, Heyderman, Robert   +4 more
openaire   +2 more sources

Rab GTPases in Immunity and Inflammation

Frontiers in Cellular and Infection Microbiology, 2017
Strict spatiotemporal control of trafficking events between organelles is critical for maintaining homeostasis and directing cellular responses. This regulation is particularly important in immune cells for mounting specialized immune defenses.
Akriti Prashar, Laura Schnettger, Elliott M. Bernard, Maximiliano G. Gutierrez   +3 more
doaj   +1 more source

Class IA phosphatidylinositol 3-kinase p110α regulates phagosome maturation. [PDF]

PLoS ONE, 2012
Of the various phosphatidylinositol 3- kinases (PI3Ks), only the class III enzyme Vps34 has been shown to regulate phagosome maturation. During studies of phagosome maturation in THP-1 cells deficient in class IA PI3K p110α, we discovered that this PI3K ...
Emily P Thi, Ulrike Lambertz, Neil E Reiner   +2 more
doaj   +1 more source

Real-time visualization of phagosomal pH manipulation by Cryptococcus neoformans in an immune signal-dependent way

Frontiers in Cellular and Infection Microbiology, 2022
Understanding of how intracellular pathogens survive in their host cells is important to improve management of their diseases. This has been fruitful for intracellular bacteria, but it is an understudied area in fungal pathogens.
Emmanuel J. Santiago-Burgos, Peter V. Stuckey, Felipe H. Santiago-Tirado, Felipe H. Santiago-Tirado, Felipe H. Santiago-Tirado   +4 more
doaj   +1 more source

Phagosome proteomes open the way to a better understanding of phagosome function [PDF]

Genome Biology, 2007
Phagocytic cells take up microbes and other particles into membrane-bounded organelles called phagosomes. Studies on the protein and lipid composition of model phagosomes containing latex beads are the first step in a systems-biology approach to understanding how these organelles function.
Griffiths, Gareth, Mayorga, Luis
openaire   +2 more sources