Results 41 to 50 of about 1,824 (206)

Cocrystal Applications in Drug Delivery

Pharmaceutics, 2020
Over the past two decades, considerable research efforts in academia and industry have gone into pharmaceutical cocrystals [...]
Andrea Erxleben
doaj   +1 more source

Continuous Manufacture and Scale-Up of Theophylline-Nicotinamide Cocrystals

Pharmaceutics, 2021
The aim of the study was the manufacturing and scale-up of theophylline-nicotinamide (THL-NIC) pharmaceutical cocrystals processed by hot-melt extrusion (HME).
Steven A. Ross, Andrew P. Hurt, Milan Antonijevic, Nicolaos Bouropoulos, Adam Ward, Pat Basford, Mark McAllister, Dennis Douroumis   +7 more
doaj   +1 more source

Identification and Pharmaceutical Characterization of a New Itraconazole Terephthalic Acid Cocrystal

Pharmaceutics, 2020
The crystallization of poorly soluble drug molecules with an excipient into new solid phases called cocrystals has gained a considerable popularity in the pharmaceutical field.
Ricardo Machado Cruz, Tereza Boleslavská, Josef Beránek, Eszter Tieger, Brendan Twamley, Maria Jose Santos-Martinez, Ondřej Dammer, Lidia Tajber   +7 more
doaj   +1 more source

Pharmaceutical Cocrystal of Piroxicam: Design, Formulation and Evaluation [PDF]

Advanced Pharmaceutical Bulletin, 2017
Purpose: Cocrystallisation of drug with coformers is a promising approach to alter the solid sate properties of drug substances like solubility and dissolution.
Prabhakar Panzade, Giridhar Shendarkar, Sarfaraj Shaikh, Pavan Balmukund Rathi   +3 more
doaj   +1 more source

Formation Thermodynamics of Carbamazepine with Benzamide, Para-Hydroxybenzamide and Isonicotinamide Cocrystals: Experimental and Theoretical Study

Pharmaceutics, 2022
Formation thermodynamic parameters for three cocrystals of carbamazepine (CBZ) with structurally related coformers (benzamide (BZA), para-hydroxybenzamide (4-OH-BZA) and isonicotinamide (INAM)) were determined by experimental (cocrystal solubility and ...
Alex N. Manin, Denis E. Boycov, Olga R. Simonova, Tatyana V. Volkova, Andrei V. Churakov, German L. Perlovich   +5 more
doaj   +1 more source

The Vortex-Slurry Implementation: A Cheap, Easy, and Ultrafast Mechanochemical Tool to Synthesize/Screen Pharmaceutical Salts and Cocrystals. [PDF]

ACS Omega
N de Souza P, Militão LVC, Firmino PP, de O Santiago PH, H de Araujo-Neto J, Ellena J, da Silva CCP.   +6 more
europepmc   +2 more sources

Amorphization of Ethenzamide and Ethenzamide Cocrystals—A Case Study of Single and Binary Systems Forming Low-Melting Eutectic Phases Loaded on/in Silica Gel

Pharmaceutics, 2023
The applicability of different solvent-free approaches leading to the amorphization of active pharmaceutical ingredients (APIs) was tested. Ethenzamide (ET), an analgesic and anti-inflammatory drug, and two ethenzamide cocrystals with glutaric acid (GLU)
Katarzyna Trzeciak, Ewelina Wielgus, Sławomir Kaźmierski, Tomasz Pawlak, Marek J. Potrzebowski   +4 more
doaj   +1 more source

Cocrystals by Design: A Rational Coformer Selection Approach for Tackling the API Problems

Pharmaceutics, 2023
Active pharmaceutical ingredients (API) with unfavorable physicochemical properties and stability present a significant challenge during their processing into final dosage forms.
Maan Singh, Harsh Barua, Vaskuri G. S. Sainaga Jyothi, Madhukiran R. Dhondale, Amritha G. Nambiar, Ashish K. Agrawal, Pradeep Kumar, Nalini R. Shastri, Dinesh Kumar   +8 more
doaj   +1 more source

Engineering Cocrystals of Poorly Water-Soluble Drugs to Enhance Dissolution in Aqueous Medium

Pharmaceutics, 2018
Biopharmaceutics Classification System (BCS) Class II and IV drugs suffer from poor aqueous solubility and hence low bioavailability. Most of these drugs are hydrophobic and cannot be developed into a pharmaceutical formulation due to their poor aqueous ...
Indumathi Sathisaran, Sameer Vishvanath Dalvi   +1 more
doaj   +1 more source

Synthesis of 1,2,3,4‐Tetrahydroisoquinoline‐3‐Carboxylic Acid‐Embedded Decapeptides: In Silico Studies and In Vitro Evaluation Against Breast Cancer

ChemistryOpen, EarlyView.
Synthesized decapeptides were designed and validated by in silico studies. They have significantly exhibited anticancer potential against breast cancer and MCF‐7 cell line. The above illustration specifies the synthetic pathway, biological screening, and the mode of action of the peptide in blocking the pathways responsible for the growth of cancer ...
Sunil Tivari, Naurin Lalani, Pritam Bagwe, Prashant Chandole, Ramesh Pawar, Enrique Delgado‐Alvarado, Abdallah Othman Ghnaim, Yashwantsinh Jadeja   +7 more
wiley   +1 more source