Population Pharmacokinetics and Pharmacodynamics of Extended-Infusion Piperacillin and Tazobactam in Critically Ill Children [PDF]
, 2015 The study objective was to evaluate the population pharmacokinetics and pharmacodynamics of extended-infusion piperacillintazobactam in children hospitalized in an intensive care unit.
Buenger, Lauren E. +7 more
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BMC Genomics, 2018 Background 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) is a widely used entactogenic drug known to impair cognitive functions on the long-run. Both hippocampal and frontal cortical regions have well established roles in behavior, memory formation
Peter Petschner +6 more
doaj +1 more source
Fluconazole Monotherapy Is a Suboptimal Option for Initial Treatment of Cryptococcal Meningitis Because of Emergence of Resistance. [PDF]
, 2019 Cryptococcal meningitis is a lethal disease with few therapeutic options. Induction therapy with fluconazole has been consistently demonstrated to be associated with suboptimal microbiological and clinical outcomes. Exposure to fluconazole causes dynamic
Aller +31 more
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p-Synephrine and its various pharmacological effects
Current Issues in Pharmacy and Medical Sciences, 2021 There is a number of diseases for which, scientists are constantly looking for a promising new treatments. Isolation of novel substances with biological activity from plants gives hope for its use in treatment.
Ziemichod Wojciech +4 more
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Metabolism of ticagrelor in patients with acute coronary syndromes. [PDF]
, 2018 © The Author(s) 2018Ticagrelor is a state-of-the-art antiplatelet agent used for the treatment of patients with acute coronary syndromes (ACS). Unlike remaining oral P2Y12 receptor inhibitors ticagrelor does not require metabolic activation to exert its ...
B Ibanez +41 more
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Pharmacodynamic Analysis of a Fluid Challenge. [PDF]
, 2015 OBJECTIVE: This study aims to describe the pharmacodynamics of a fluid challenge over a 10-minute period in postoperative patients. DESIGN: Prospective observational study. SETTING: General and cardiothoracic ICU, tertiary hospital.
Aya, HD +5 more
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Pharmacodynamics of Fluoroquinolones [PDF]
Clinical Infectious Diseases, 1998 Fluoroquinolone antimicrobial agents are highly active against aerobic or facultative gram-negative bacilli. The fluoroquinolones have been shown to be very concentration dependent in their rates of killing and also have a postantibiotic effect against most gram-negative pathogens.
Klaus Borner, Peter Koeppe, Hartmut Lode
openaire +3 more sources
Pharmacodynamic modelling of in vitro activity of tetracycline against a representative, naturally occurring population of porcine Escherichia coli [PDF]
, 2015 Background The complex relationship between drug concentrations and bacterial growth rates require not only the minimum inhibitory concentration but also other parameters to capture the dynamic nature of the relationship.
Agersø, Yvonne +9 more
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Pharmacokinetics and Pharmacodynamics of Tedizolid [PDF]
Clinical Pharmacokinetics, 2022 Tedizolid is an oxazolidinone antibiotic with high potency against Gram-positive bacteria and currently prescribed in bacterial skin and skin-structure infections. The aim of the review was to summarize and critically review the key pharmacokinetic and pharmacodynamic aspects of tedizolid.
Khalid Iqbal +2 more
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Can we prevent antimicrobial resistance by using antimicrobials better? [PDF]
, 2013 Since their development over 60 years ago, antimicrobials have become an integral part of healthcare practice worldwide. Recently, this has been put in jeopardy by the emergence of widespread antimicrobial resistance, which is one of the major problems ...
Brown +27 more
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