Oliceridine — a unique drug among opioid analgesics
Journal of Medical Science, 2020 Oliceridine is an opioid with a different mechanism of action compared to classical opioid agonists, e.g. morphine, as it does not act through active metabolites and activates the β-arrestin pathway to a small extent, thereby reducing dangerous side ...
Ewa Gibuła-Tarłowska +2 more
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Comparison of the qCON and qNOX indices for the assessment of unconsciousness level and noxious stimulation response during surgery [PDF]
, 2016 The objective of this work is to compare the performances of two electroencephalogram based indices for detecting loss of consciousness and loss of response to nociceptive stimulation.
Agustí, Mercé +8 more
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Population Pharmacokinetics and Pharmacodynamics of Artemether and Lumefantrine During Combination Treatment in Children with Uncomplicated Falciparum Malaria in Tanzania. [PDF]
, 2010 The combination of artemether (ARM) and lumefantrine is currently the first-line treatment of uncomplicated falciparum malaria in mainland Tanzania. While the exposure to lumefantrine has been associated with the probability of adequate clinical and ...
Annerberg, Anna +10 more
core +4 more sources
European Psychiatry, 2023 Introduction Depressive disorders are known heterogeneous both in their clinical manifestations and etiopathophysiology. Affective temperaments have a strong biological background and heritability, manifest at early age and remain stable throughout the ...
D. Győrik +7 more
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Pharmacodynamics of fluoroquinolones [PDF]
Journal of Antimicrobial Chemotherapy, 1999 Abstract Fluctuating concentrations of three fluoroquinolones (moxifloxacin, sparfloxacin and ofloxacin) and a β-lactam (amoxycillin) were used in vitro to simulate antibiotic concentrations in human serum after oral doses of antibiotics.
openaire +3 more sources
A phase I pharmacokinetic and pharmacodynamic study of the oral mitogen-activated protein kinase kinase (MEK) inhibitor, WX-554, in patients with advanced solid tumours [PDF]
, 2016 Purpose: We performed a multi-centre phase I study to assess the safety, pharmacokinetics (PK) and pharmacodynamics (PD) of the orally available small molecule mitogen-activated protein kinase kinase (MEK) 1/2 inhibitor, WX-554, and to determine the ...
Allen, Rodger +21 more
core +2 more sources
Role of therapeutic drug monitoring in pulmonary infections : use and potential for expanded use of dried blood spot samples [PDF]
, 2015 Respiratory tract infections are among the most common infections in men. We reviewed literature to document their pharmacological treatments, and the extent to which therapeutic drug monitoring (TDM) is needed during treatment.
Akkerman, Onno W +6 more
core +5 more sources
Evaluation of dosing strategy for pembrolizumab for oncology indications
Journal for ImmunoTherapy of Cancer, 2017 Background Traditionally, most monoclonal antibodies (mAbs) have been dosed based on body weight because of perceived contribution of body size in pharmacokinetic variability.
Tomoko Freshwater +6 more
doaj +1 more source
OSMOLOGY AND PHARMACODYNAMICS. [PDF]
JAMA: The Journal of the American Medical Association, 1905 Osmology is usually defined as the science treating of the osmotic states of the body fluids. However, as the osmotic processes in a liquid in a great measure reflect also its other physical conditions, this fact should be embraced in an adequate definition. Osmology, hence, may be spoken of as the knowledge concerning the physical conditions of and in
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Pharmacokinetics and pharmacodynamics of tiotropium solution and tiotropium powder in chronic obstructive pulmonary disease [PDF]
, 2013 The aim of the study was to characterize pharmacokinetics of tiotropium solution 5 µg compared to powder 18 µg and assess dose-dependency of tiotropium solution pharmacodynamics in comparison to placebo.
Cornelissen, PJG +7 more
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