Results 121 to 130 of about 53,742 (236)

Evaluation of commonly used ectoderm markers in iPSC trilineage differentiation. [PDF]

, 2019
Patient-derived induced pluripotent stem cells (iPSCs) have become a promising resource for exploring genetics of complex diseases, discovering new drugs, and advancing regenerative medicine.
Iacovino, Michelina, Iribarren, Carlos, Krauss, Ronald M, Kuang, Yu-Lin, Mattis, Aras N, Medina, Marisa W, Munoz, Antonio, Nalula, Gilbert, Sanchez, Gabriela, Sanghez, Valentina, Santostefano, Katherine E, Terada, Naohiro   +11 more
core  

Clinical trials in pharmacogenetics and pharmacogenomics: Methods and applications [PDF]

, 2000
Patrice Rioux
openalex   +1 more source

Genomics and epilepsy: Opportunities to improve understanding and management

Developmental Medicine &Child Neurology, EarlyView.
Accessing the entire genome, beyond any single causal variant for an individual's condition, may reveal additional genetic information of value in the understanding or care for that person. Combining such data with additional sources of information from that individual may enhance understanding and care further.
Sanjay M. Sisodiya
wiley   +1 more source

Update on the pharmacogenomics of pain management

Pharmacogenomics and Personalized Medicine, 2019
Alan David Kaye,1 Andrew Jesse Garcia,2 O Morgan Hall,3 George M Jeha,4 Kelsey D Cramer,4 Amanda L Granier,4 Anusha Kallurkar,5 Elyse M Cornett,5 Richard D Urman61Department of Anesthesiology, LSU Health Sciences Center, New Orleans, LA, USA; 2Department
Kaye AD, Garcia AJ, Hall OM, Jeha GM, Cramer KD, Granier AL, Kallurkar A, Cornett EM, Urman RD   +8 more
doaj  

Transforming Pharmacogenomics and CRISPR Gene Editing with the Power of Artificial Intelligence for Precision Medicine

Pharmaceutics
Background: Advancements in pharmacogenomics, artificial intelligence (AI), and CRISPR gene-editing technology are revolutionizing precision medicine by enabling highly individualized therapeutic strategies.
Amit Kumar Srivastav, Manoj Kumar Mishra, James W. Lillard, Rajesh Singh   +3 more
doaj   +1 more source

Incentivizing the Utilization of Pharmacogenomics in Drug Development [PDF]

, 2012
Pharmacogenomics, the study and development of compounds according to how an individual’s genes affects the body’s response to drugs, holds enormous promise for increasing the safety and efficiency of drug development while decreasing adverse reactions ...
Koch, Valerie Gutmann
core   +1 more source

Personalized care of paediatric drug‐resistant epilepsy in Africa: A single‐centre pilot study utilizing mobile health and genetic testing

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To evaluate personalized care or precision medicine initiatives, including mobile health (mHealth) technology and genetic screening, in a South African paediatric epilepsy clinic. Method This exploratory prospective observational pilot study included 39 children aged 4 years or older with drug‐resistant epilepsy (ongoing seizures despite ...
Ian S. Olivier, Karen Fieggen, Sandra Komarzynski, Elin H. Davies, Irene Muchada, Caitlin McIntosh, Alina Esterhuizen, Richard J. Burman, Jo M. Wilmshurst, And the University of Cape Town (UCT) Human Genetics Precision Medicine Epilepsy Group, Nicholas Loxton, Shrinav R Dawlatt, Akshay Vanmali   +12 more
wiley   +1 more source

The challenge of pharmacogenetics and pharmacogenomics [PDF]

, 2000
Robert Snedden
openalex   +1 more source

Pharmacogenomics in Practice [PDF]

Clinical Pharmacology & Therapeutics, 2019
Liewei Wang, Richard M. Weinshilboum
openaire   +3 more sources

Electrical stimulation of stem cell–derived human neural networks for evaluating anti‐seizure medications

Epilepsia, EarlyView.
Abstract Objective Current preclinical epilepsy drug screening relies on animal models that poorly reflect human neurophysiology, leading to high failure rates in clinical translation. We aimed to establish a human in vitro model using human‐induced pluripotent stem cell (hiPSC)–derived cortical neurons cultured on multielectrode arrays (MEAs), capable
Joshua Nicholls, Jinchao Gu, Zhibin Chen, Zikou Liu, Ana Antonic‐Baker, Muhammad Shahid Javaid, Eliza Moore, Hailin Zhu, Afaf Altalhi, David K. Wright, Huseyin Sumer, Terence J. O'Brien, Patrick Kwan, Ben Rollo   +13 more
wiley   +1 more source