Results 1 to 10 of about 916,385 (296)
Pharmacokinetics and Pharmacodynamics of PARP Inhibitors in Oncology
Clinical Pharmacokinetics, 2022 Olaparib, niraparib, rucaparib, and talazoparib are poly (ADP-ribose) polymerase (PARP) inhibitors approved for the treatment of ovarian, breast, pancreatic, and/or prostate cancer.
M. Bruin +3 more
semanticscholar +1 more source
Pharmacology Research & Perspectives, 2023 Daprodustat is an oral small molecule hypoxia‐inducible factor (HIF) prolyl hydroxylase inhibitor (PHI) approved in Japan and the United States for the treatment of anemia associated with chronic kidney disease.
Guoying Tai +8 more
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The pharmacokinetics of amygdalin [PDF]
Archives of Toxicology, 1982 Amygdalin (D-mandelonitrile-beta-D-gentiobioside) is a cyanogenic glycoside claimed to show anti-cancer activity, sold under the incorrect name "Laetrile". For a sensible discussion of its alleged activity and its established toxicity it is necessary that its fate in the organism is known. The pharmacokinetics of amygdalin have been investigated in the
Rauws, AG, Olling, M, Timmerman, A
openaire +3 more sources
Frontiers in Pharmacology, 2022 Biowaiver based on the biopharmaceutics classification system (BCS) has been widely used in the global market for the approval of new generic drug products to avoid unnecessary in vivo bioequivalence (BE) studies.
Xian Zhang +7 more
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Sex differences in pharmacokinetics predict adverse drug reactions in women
Biology of Sex Differences, 2020 Women experience adverse drug reactions, ADRs, nearly twice as often as men, yet the role of sex as a biological factor in the generation of ADRs is poorly understood.
I. Zucker, B. Prendergast
semanticscholar +1 more source
Molecules, 2021 Enzymes, receptors, and other binding molecules in biological processes can recognize enantiomers as different molecular entities, due to their different dissociation constants, leading to diverse responses in biological processes. Enantioselectivity can
Maria Miguel Coelho +3 more
semanticscholar +1 more source
CPT: Pharmacometrics & Systems Pharmacology, 2021 Platelets are produced by hematopoietic stem cells via megakaryocytes in the bone marrow and play a critical role in hemostasis. The aim of this study was to develop a new platelet model based on the thrombopoiesis and platelet life‐cycle by a ...
Ryosuke Shimizu +2 more
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Scientific Reports, 2020 Oligonucleotide therapeutics use short interfering RNA (siRNA) or antisense oligonucleotide (ASO) molecules to exploit endogenous systems—neutralizing target RNA to prevent subsequent protein translation. While the potential clinical application is vast,
Mai B. Thayer +5 more
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Population Pharmacokinetics and Bayesian Dose Adjustment to Advance TDM of Anti-TB Drugs
Clinical Pharmacokinetics, 2021 Tuberculosis (TB) is still the number one cause of death due to an infectious disease. Pharmacokinetics and pharmacodynamics of anti-TB drugs are key in the optimization of TB treatment and help to prevent slow response to treatment, acquired drug ...
Marieke G. G. Sturkenboom +9 more
semanticscholar +1 more source
Pharmacology Research & Perspectives, 2020 In clinical pharmacology, the free drug hypothesis has been widely applied in the interpretation of the relationship between pharmacokinetics and pharmacodynamics (PK/PD).
Chun Chen +21 more
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