Results 1 to 10 of about 627,428 (343)

Investigation of the human metabolism and disposition of the prolyl hydrolase inhibitor daprodustat using IV microtracer with Entero‐Test bile string

Pharmacology Research & Perspectives, 2023
Daprodustat is an oral small molecule hypoxia‐inducible factor (HIF) prolyl hydroxylase inhibitor (PHI) approved in Japan and the United States for the treatment of anemia associated with chronic kidney disease.
Guoying Tai, Fangming Xia, Cathy Chen, Adrian Pereira, Jill Pirhalla, Xiusheng Miao, Graeme Young, Claire Beaumont, Liangfu Chen   +8 more
doaj   +1 more source

A Physiologically Based Pharmacokinetic Model for Studying the Biowaiver Risk of Biopharmaceutics Classification System Class I Drugs With Rapid Elimination: Dexketoprofen Trometamol Case Study

Frontiers in Pharmacology, 2022
Biowaiver based on the biopharmaceutics classification system (BCS) has been widely used in the global market for the approval of new generic drug products to avoid unnecessary in vivo bioequivalence (BE) studies.
Xian Zhang, Xuxiao Ye, Kuan Hu, Wenping Li, Wenqian Li, Qingqing Xiao, Lin Chen, Jin Yang   +7 more
doaj   +1 more source

Quantitative systems pharmacology model of thrombopoiesis and platelet life‐cycle, and its application to thrombocytopenia based on chronic liver disease

CPT: Pharmacometrics & Systems Pharmacology, 2021
Platelets are produced by hematopoietic stem cells via megakaryocytes in the bone marrow and play a critical role in hemostasis. The aim of this study was to develop a new platelet model based on the thrombopoiesis and platelet life‐cycle by a ...
Ryosuke Shimizu, Takayuki Katsube, Toshihiro Wajima   +2 more
doaj   +1 more source

POE Immunoassay: Plate-based oligonucleotide electro-chemiluminescent immunoassay for the quantification of nucleic acids in biological matrices

Scientific Reports, 2020
Oligonucleotide therapeutics use short interfering RNA (siRNA) or antisense oligonucleotide (ASO) molecules to exploit endogenous systems—neutralizing target RNA to prevent subsequent protein translation. While the potential clinical application is vast,
Mai B. Thayer, Sara C. Humphreys, Kyu S. Chung, Julie M. Lade, Kevin D. Cook, Brooke M. Rock   +5 more
doaj   +1 more source

Applicability of free drug hypothesis to drugs with good membrane permeability that are not efflux transporter substrates: A microdialysis study in rats

Pharmacology Research & Perspectives, 2020
In clinical pharmacology, the free drug hypothesis has been widely applied in the interpretation of the relationship between pharmacokinetics and pharmacodynamics (PK/PD).
Chun Chen, Hongyu Zhou, Chi Guan, Huanhuan Zhang, Yingying Li, Xue Jiang, Zheng Dong, Yuanyuan Tao, Juan Du, Shuyao Wang, Teng Zhang, Na Du, Junyang Guo, Yaqiong Wu, Zehai Song, Haofei Luan, Yu Wang, Hongwen Du, Shaofeng Zhang, Chen Li, Hang Chang, Tao Wang   +21 more
doaj   +1 more source

Digoxin absorption decreased independently of P-gp activity in rats with irinotecan-induced gastrointestinal damage

Journal of Pharmaceutical Health Care and Sciences, 2021
Background Irinotecan (CPT-11) is clinically known to cause severe diarrhea and gastrointestinal damage. Recently, we have reported that CPT-11-induced gastrointestinal damage is associated with the upregulation of intestinal P-glycoprotein (P-gp ...
Toshiaki Tsuchitani, Takeshi Akiyoshi, Ayuko Imaoka, Hisakazu Ohtani   +3 more
doaj   +1 more source

Population Pharmacokinetics and Pharmacodynamics of Artemether and Lumefantrine During Combination Treatment in Children with Uncomplicated Falciparum Malaria in Tanzania. [PDF]

, 2010
The combination of artemether (ARM) and lumefantrine is currently the first-line treatment of uncomplicated falciparum malaria in mainland Tanzania. While the exposure to lumefantrine has been associated with the probability of adequate clinical and ...
Annerberg, Anna, Ashton, Michael, Björkman, Anders, Dahlström, Sabina, Färnert, Anna, Gil, Pedro, Hietala, Sofia Friberg, Lindegårdh, Niklas, Mårtensson, Andreas, Ngasala, Billy, Premji, Zul   +10 more
core   +4 more sources

Tumor necrosis factor inhibitors in psoriatic arthritis. [PDF]

, 2017
INTRODUCTION: Psoriatic arthritis (PsA) is a chronic inflammatory disease that can result in significant disability. With the emergence of tumor necrosis factor inhibitors (TNFi), therapeutic outcomes in PsA have improved substantially.
Kraft, Walter K., Mantravadi, Santhi, Ogdie, Alexis   +2 more
core   +2 more sources

Personalizing HIV therapy, mission impossible? [PDF]

, 2012
Sustained HIV suppression depends on a number of factors including therapy adherence, management of side effects, viral resistance and individual characteristics of patients and therapeutic settings.
Hentig, Nils von
core   +1 more source

Pharmacokinetics, mass balance, tissue distribution, metabolism, and excretion of praliciguat, a clinical‐stage soluble guanylate cyclase stimulator in rats

Pharmacology Research & Perspectives, 2020
The pharmacokinetics (PK), metabolism, excretion, mass balance, and tissue distribution of [14C]praliciguat were evaluated following oral administration of a 3‐mg/kg dose in Sprague‐Dawley rats and in a quantitative whole‐body autoradiography (QWBA ...
Ali R. Banijamali, Andrew E. Carvalho, James D. Wakefield, Peter Germano, Timothy C. Barden, Jenny V. Tobin, Daniel P. Zimmer, Jaime L. Masferrer, Albert T. Profy, Mark G. Currie, G. Todd Milne   +10 more
doaj   +1 more source