Results 1 to 10 of about 803,627 (413)

Fractional Calculus in Pharmacokinetics [PDF]

J Pharmacokinet Pharmacodyn (2018) 45: 107, 2019
We are witnessing the birth of a new variety of pharmacokinetics where non-integer-order differential equations are employed to study the time course of drugs in the body: this is dubbed "fractional pharmacokinetics." The presence of fractional kinetics has important clinical implications such as the lack of a half-life, observed, for example with the ...
Pantelis Sopasakis, H. Sarimveis, P. Macheras, A. Dokoumetzidis   +3 more
arxiv   +2 more sources

Developing a Knowledge Graph Framework for Pharmacokinetic Natural Product-Drug Interactions [PDF]

Journal of Biomedical Informatics 140 (2023) 104341, 2022
Pharmacokinetic natural product-drug interactions (NPDIs) occur when botanical natural products are co-consumed with pharmaceutical drugs. Understanding mechanisms of NPDIs is key to preventing adverse events. We constructed a knowledge graph framework, NP-KG, as a step toward computational discovery of pharmacokinetic NPDIs.
arxiv   +1 more source

Pharmacokinetics, absolute bioavailability and tolerability of ketamine after intranasal administration to dexmedetomidine sedated dogs [PDF]

, 2020
Intranasal ketamine has recently gained interest in human medicine, not only for its sedative, anaesthetic or analgesic properties, but also in the management of treatment resistant depression, where it has been shown to be an effective, fast acting ...
Croubels, Siska, Devreese, Mathias, Dockx, Robrecht, Duchateau, Luc, Peremans, Kathelijne, Polis, Ingeborgh, Vlerick, Lise   +6 more
core   +1 more source

Can We Predict Individual Concentrations of Tacrolimus After Liver Transplantation? Application and Tweaking of a Published Population Pharmacokinetic Model in Clinical Practice [PDF]

Therapeutic Drug Monitoring, 2021, 43 (4), pp.490-498, 2023
Background: Various population pharmacokinetic models have been developed to describe the pharmacokinetics of tacrolimus in adult liver transplantation. However, their extrapolated predictive performance remains unclear in clinical practice. The purpose of this study was to predict concentrations using a selected literature model and to improve these ...
arxiv   +1 more source

Tumor necrosis factor inhibitors in psoriatic arthritis. [PDF]

, 2017
INTRODUCTION: Psoriatic arthritis (PsA) is a chronic inflammatory disease that can result in significant disability. With the emergence of tumor necrosis factor inhibitors (TNFi), therapeutic outcomes in PsA have improved substantially.
Kraft, Walter K., Mantravadi, Santhi, Ogdie, Alexis   +2 more
core   +2 more sources

Personalizing HIV therapy, mission impossible? [PDF]

, 2012
Sustained HIV suppression depends on a number of factors including therapy adherence, management of side effects, viral resistance and individual characteristics of patients and therapeutic settings.
Hentig, Nils von
core   +1 more source

Pharmacokinetic/pharmacodynamic modelling approaches in paediatric infectious diseases and immunology. [PDF]

, 2014
Pharmacokinetic/pharmacodynamic (PKPD) modelling is used to describe and quantify dose-concentration-effect relationships. Within paediatric studies in infectious diseases and immunology these methods are often applied to developing guidance on ...
Abdel-Rahman, Ahsman, Ambrose, Anderson, Anderson, Anderson, Andes, Andes, Assael, Baley, Barclay, Barclay, Barlogis, Bartelink, Bayles, Benjamin, Benson, Berger, Bhandari, Blumer, Bomgaars, Bonate, Botha, Bouazza, Bradley, Buck, Burkhardt, Call, Charles, Charlotte I.S. Barker, Charrier, Chen, Clave, Cohen-Wolkowiez, Cohen-Wolkowiez, Committee, Craig, De Beaudrap, de Groot, de Hoog, de Hoog, de Hoog, de Repentigny, Doby, Doogue, Dowell, Downing, Driscoll, Driscoll, Drusano, Drylewicz, Du, Dudley, Duval, Elter, Englund, Ette, Ette, Ette, Eva Germovsek, Fallen, Fedele, Filler, Fletcher, Foot, Forrest, Frenkel, Friberg, Garcia, Garrido, Giannelli, Giuliano, Glowka, Gonzalez-Peralta, Grimsley, Groll, Groll, Guedj, Hassan, Hennig, Herbrecht, Hintz, Hong, Hope, Hope, Hope, Hope, Hosoya, Huenecke, Iida, Ikawa, Izquierdo, Jacqz-Aigrain, Jensen, Joanna Lewis, Jodi M. Lestner, Joseph F. Standing, Kafetzis, Karlsson, Kaufman, Kearns, Kelley, Kicklighter, Kim, Kimberlin, Kimberlin, Kimberlin, Knoderer, Koehl, Koenig, Kohli, Krakovska, Krishna, Lam, Lankester, Lavielle, Lee, Lee, Lestner, Lewis, Lewis, Lewis, Li, Li, Lodise, Louie, Luck, Lukas, Marques-Minana, McJunkin, Meszner, Mohamed, Moore, Muller, Muller, Neely, Neely, Nielsen, Ogungbenro, Ohata, Olkinuora, Oxford, Padari, Palumbo, Parker, Pascual, Payen, Perelson, Pescovitz, Pescovitz, Piper, Plunkett, Prague, Preston, Pullen, Putter, Rajagopalan, Renard, Rodriguez, Rodriguez-Tudela, Rollo L. Hoare, Rong, Rudd, Sabin, Saez-Llorens, Saez-Llorens, Salinger, Sardemann, Saxen, Schaefer, Schmitt, Schwinger, Seibel, Seidel, Sherwin, Smith, Standing, Starke, Sugaya, Sullender, Surh, Suyagh, Tamma, Tarral, Tasso, Tedeschi, Terragna, Thiebaut, Thiébaut R, Tod, Tod, Touw, Tulkens, van den Anker, van Hasselt, Vandecasteele, Vaudry, Vervelde, Vezina, Walsh, Waxman, Willemze, Wu, Wurthwein, Yoshizawa, Zeng, Zhang, Zhao, Zobell   +208 more
core   +1 more source

Therapeutic and toxic blood concentrations of nearly 1,000 drugs and other xenobiotics [PDF]

, 2012
Introduction: In order to assess the significance of drug levels measured in intensive care medicine, clinical and forensic toxicology, as well as for therapeutic drug monitoring, it is essential that a comprehensive collection of data is readily ...
Andresen, Hilke, Iwersen-Bergmann, Stefanie, Schmoldt, Achim, Schulz, Martin   +3 more
core   +1 more source

Medication Complications in Extracorporeal Membrane Oxygenation. [PDF]

, 2017
The need for extracorporeal membrane oxygenation (ECMO) therapy is a marker of disease severity for which multiple medications are required. The therapy causes physiologic changes that impact drug pharmacokinetics.
Aebi, Ami G. Shah, Anderson, Arlt, Barr, Barthelemy, Beiderlinden, Bein, Bembea, Bhatt-Meht, Boucher, Brandi N. Thoma, Brown, Buck, Buscher, Chung, Dagan, Dagan, de Montmollin, De Rosa, DeGrado, Donadello, Donadello, Dzierba, Erstad, Esper, Eyler, Flordelis Lasierra, Glauber, Greenberg, Gélisse, Hadidi, Hertzog, Hraiech, Hynynen, Johnston, Kawada, Kim, Koster, Krueger, Lamarche, Latronico, Lemaitre, Levison, Malfertheiner, Mehta, Michelle Peahota, Moore, Mousavi, Mulla, Mulla, Muntean, Oliver, Paden, Park, Perkins, Peters, Pettignano, Phillips, Pieri, Potter, Preston, Protti, Ranucci, Riker, Roberts, Roos, Rosen, Ruiz, Rybak, Saini, Sanfilippo, Satyapriya, Schmith, Shekar, Shekar, Shekar, Shekar, Shekar, Sherwin, Sklar, Smith, Spriet, Staudacher, Strunk, Subramaniam, Szefner, Tellor, Trudzinski, Tulman, Turner, Veinstein, Vilay, Wagner, Walter K. Kraft, Welsch, Wen, Wildschut, Wu, Young   +99 more
core   +2 more sources

Role of therapeutic drug monitoring in pulmonary infections : use and potential for expanded use of dried blood spot samples [PDF]

, 2015
Respiratory tract infections are among the most common infections in men. We reviewed literature to document their pharmacological treatments, and the extent to which therapeutic drug monitoring (TDM) is needed during treatment.
Akkerman, Onno W, Alffenaar, Jan-Willem C, Bolhuis, Mathieu S, Hofman, Susan, Koster, Remco A, Stove, Christophe, van Assen, Sander   +6 more
core   +2 more sources