Results 1 to 10 of about 228,193 (248)

Targeted treatment for neuroblastoma using methoxyestradiol (2-ME)-loaded mitochondria-targeting immunoliposomes modified by datuximab (anti-GD2) and (L-cyclohexyl alanine-D-arginine)3 ((Fx,r)3) peptide

Cancer Nanotechnology
The 2-ME therapy encounters significant challenges in practical use. Its low water solubility compromises bioavailability, limiting drug efficacy. In addition, poor stability in the physiological environment hinders sustained therapeutic effects, and ...
Mingyu Wan, Zhili Chen, Yueyi Deng, Robert J. Lee, Chengyun Yan   +4 more
doaj   +1 more source

REV-ERBα integrates colon clock with experimental colitis through regulation of NF-κB/NLRP3 axis

Nature Communications, 2018
REV-ERBα is a nuclear receptor that links the circadian pathways with those of metabolism. Here the authors show REV-ERBα is also involved with linking the circadian system with the inflammatory pathways of an experimental model of colitis through ...
Shuai Wang, Yanke Lin, Xue Yuan, Feng Li, Lianxia Guo, Baojian Wu   +5 more
doaj   +1 more source

Effect of Renal Impairment on Pharmacokinetics and Safety of Ensitrelvir, a SARS-CoV-2 3CL Protease Inhibitor

Infectious Diseases and Therapy
Introduction Ensitrelvir, a novel oral inhibitor of 3C-like protease of SARS-CoV-2, shows efficacy and safety in participants with mild to moderate COVID-19.
Takayuki Katsube, Safwan Kezbor, Ryosuke Shimizu, Ryuji Kubota   +3 more
doaj   +1 more source

Simultaneously Predicting the Pharmacokinetics of CES1-Metabolized Drugs and Their Metabolites Using Physiologically Based Pharmacokinetic Model in Cirrhosis Subjects

Pharmaceutics
Hepatic carboxylesterase 1 (CES1) metabolizes numerous prodrugs into active ingredients or direct-acting drugs into inactive metabolites. We aimed to develop a semi-physiologically based pharmacokinetic (semi-PBPK) model to simultaneously predict the ...
Xin Luo, Zexin Zhang, Ruijing Mu, Guangyu Hu, Li Liu, Xiaodong Liu   +5 more
doaj   +1 more source

Kinetic measurements of membrane target level and on-cell binding of biotherapeutic antibodies using flow-cytometry

AAPS Open
Characterization of cell surface target expression is critical for the development of therapeutics that bind membrane proteins or use changes in target abundance as efficacy biomarkers.
Daniel T. Doty, Mahua Roy, Phanidhar Kukutla, Nicholas Lucarelli, Peter E. Struss, Lindsay E. King, Jeffrey R. Chabot, Jatin Narula, Hendrik Neubert, Polina Goihberg   +9 more
doaj   +1 more source

The Role of Aggregates of Therapeutic Protein Products in Immunogenicity: An Evaluation by Mathematical Modeling

Journal of Immunology Research, 2015
Therapeutic protein products (TPP) have been widely used to treat a variety of human diseases, including cancer, hemophilia, and autoimmune diseases. However, TPP can induce unwanted immune responses that can impact both drug efficacy and patient safety.
Liusong Yin, Xiaoying Chen, Abhinav Tiwari, Paolo Vicini, Timothy P. Hickling   +4 more
doaj   +1 more source

Pyridoxic Acid as Endogenous Biomarker of Renal Organic Anion Transporter Activity: Population Variability and Mechanistic Modeling to Predict Drug–Drug Interactions

CPT: Pharmacometrics & Systems Pharmacology
Pyridoxic acid (PDA) was suggested as a potential endogenous biomarker to assess in vivo renal organic anion transporter (OAT) 1 and 3 activity. Here, we first investigated the population variability in the plasma baseline levels of PDA using data from ...
Aarzoo Thakur, Sumathy Mathialagan, Emi Kimoto, Manthena V. S. Varma   +3 more
doaj   +1 more source

A comparison between the combined effect of calcium carbonate with sucroferric oxyhydroxide and other phosphate binders: an in vitro and in vivo experimental study

BMC Nephrology, 2019
Background Approximately 30% of patients on dialysis received combination therapy for their phosphate binder prescription; however, few studies for combined effects of phosphate binders are reported.
Atsushi Yaguchi, Kenji Akahane, Kumi Tsuchioka, Saori Yonekubo, Shota Yamamoto, Yasuaki Tamai, Satoshi Tatemichi, Hiroo Takeda   +7 more
doaj   +1 more source

Pharmacokinetics [PDF]

QJM, 1996
openaire   +2 more sources

Analysis of the contributing role of drug transport across biological barriers in the development and treatment of chemotherapy-induced peripheral neuropathy

Fluids and Barriers of the CNS
Background Chemotherapy-induced peripheral neuropathy (CIPN) represents a major unmet medical need that currently has no preventive and/or curative treatment.
Yang Hu, Milda Girdenyté, Lieke Roest, Iida Liukkonen, Maria Siskou, Frida Bällgren, Margareta Hammarlund-Udenaes, Irena Loryan   +7 more
doaj   +1 more source