Results 191 to 200 of about 628,142 (342)

Quantitative Prediction of Human Pharmacokinetics for Fc-Engineered Therapeutic Monoclonal Antibodies With Increased FcRn Binding Mutations After Subcutaneous Injection. [PDF]

Clin Transl Sci
Haraya K, Kuramochi T.
europepmc   +1 more source

Physiologically based pharmacokinetic modeling of arterial – antecubital vein concentration difference [PDF]

, 2004
David G. Levitt
openalex   +1 more source

Learned Conformational Space and Pharmacophore Into Molecular Foundational Model

Advanced Science, EarlyView.
The Ouroboros model introduces two orthogonal modules within a unified framework that independently learn molecular representations and generate chemical structures. This design enables flexible optimization strategies for each module and faithful structure reconstruction without prompts or noise.
Lin Wang, Yifan Wu, Hao Luo, Minglong Liang, Yihang Zhou, Cheng Chen, Chris Liu, Jun Zhang, Yang Zhang   +8 more
wiley   +1 more source

Comment on "Phase I Randomized, Placebo-Controlled, Cross-Over Dose-Finding Study of Coenzyme Q₁₀ on Doxorubicin Pharmacokinetics During Breast Cancer Treatment". [PDF]

Integr Cancer Ther
Lei Z.
europepmc   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Fospropofol: Pharmacokinetics?

Journal of Anaesthesiology Clinical Pharmacology, 2012
Bharti Mahajan, Sandeep Kaushal, Rajesh Mahajan   +2 more
openaire   +3 more sources

Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response

Advanced Science, EarlyView.
This study identifies YqgB as a key target for restoring colistin susceptibility in mcr‐positive pathogens under acidic conditions by remodeling phospholipid composition and reducing LPS modification. Deep learning‐based screening reveals H2 receptor antagonists as novel colistin adjuvants. Further investigations indicate that ranitidine and famotidine
Jinju Cai, Mengping He, Jianya Luo, Shuang Zhou, Tengyue Zhang, Jianing Li, Zhiqiang Wang, Yuan Liu   +7 more
wiley   +1 more source

Can evolutionary therapy be applied in non-small cell lung cancer? [PDF]

Sci Rep
Jansén-Storbacka LR, Honasoge KS, Molnárová E, Soboleva A, Agema BC, Paats MS, Moes DJAR, Veerman GDM, Barbaro ABT, Dobbe R, Grossmann I, Azimi S, Mathijssen RHJ, Dingemans AC, Staňková K.   +14 more
europepmc   +1 more source

Performance of Various Pharmacokinetic Parameters in Predicting Vancomycin Serum Concentrations

, 2008
Kuniaki Sano, Norihiro Suzuki, Mitsuhiro Saitoh   +2 more
openalex   +2 more sources

A Natural Sweetener‐inducible Genetic Switch Controls Therapeutic Protein Expression in Mammals

Advanced Science, EarlyView.
This study develops a natural sweetener, the psicose‐inducible transgene expression (PURE) system based on an Agrobacterium tumefaciens–derived transcriptional repressor PsiR. The PURE system is highly specific to psicose, being insensitive to other sugars and structurally similar molecules.
Longliang Qiao, Zhihao Wang, Shasha Tang, Yuan Fang, Guiling Yu, Xiaoting Qiu, Lingxue Niu, Tao Yan, Xingwan Liu, Xiaoding Ma, Deqiang Kong, Yang Zhou, Ningzi Guan, Jinzhong Tian, Meiyan Wang, Haifeng Ye, Fengfeng Cai   +16 more
wiley   +1 more source