Results 31 to 40 of about 599,269 (342)

Pharmacokinetics for the prescriber

Medicine, 2003
Pharmacokinetics is the science that describes (using the ADME approach) the absorption of a drug from its site of administration, its distribution throughout the body, its metabolism or conjugation, and its excretion from the body. Pharmacokinetics can be thought of as what the body does to the drug.
Howard L. McLeod, Yijing He
openaire   +2 more sources

An Investigation on Glucuronidation Metabolite Identification, Isozyme Contribution, and Species Differences of GL-V9 In Vitro and In Vivo

Molecules, 2019
GL-V9 is a prominent derivative of wogonin with a wide therapeutic spectrum and potent anti-tumor activity. The metabolism characteristics of GL-V9 remain unclear.
Han Xing, Dexuan Kong, Chen Ning, Ying Kong, Chang Ren, Yujie Cheng, Hui Cai, Jubo Wang, Di Zhao, Ning Li, Xijing Chen, Zhiyu Li, Yang Lu   +12 more
doaj   +1 more source

A semimechanistic population pharmacokinetic and pharmacodynamic model incorporating autoinduction for the dose justification of TAS‐114

CPT: Pharmacometrics & Systems Pharmacology, 2022
TAS‐114 is a dual deoxyuridine triphosphatase (dUTPase) and dihydropyrimidine dehydrogenase (DPD) inhibitor expected to widen the therapeutic index of capecitabine.
Hikari Araki, Toru Takenaka, Koichi Takahashi, Fumiaki Yamashita, Kazuaki Matsuoka, Kunihiro Yoshisue, Ichiro Ieiri   +6 more
doaj   +1 more source

Metabolism of ticagrelor in patients with acute coronary syndromes. [PDF]

, 2018
© The Author(s) 2018Ticagrelor is a state-of-the-art antiplatelet agent used for the treatment of patients with acute coronary syndromes (ACS). Unlike remaining oral P2Y12 receptor inhibitors ticagrelor does not require metabolic activation to exert its ...
B Ibanez, C Varenhorst, D Alexopoulos, D Aradi, D Lindholm, D Zhou, EA Amsterdam, F Franchi, G Parodi, G Parodi, H Sillén, HS Smith, J Kubica, J Kubica, J Li, JH Cornel, JM Siller-Matula, K Butler, K Butler, K Thygesen, M Koziński, M Roffi, P Adamski, P Adamski, P Adamski, P Adamski, P Niezgoda, P Niezgoda, PG Steg, PG Steg, PT O’Gara, R Teng, R Teng, R Teng, R Teng, R Teng, R Teng, RA Lange, S Husted, S James, SE Husted, SS Brar   +41 more
core   +2 more sources

Nanomaterials and pharmacokinetics

, 2021
Nanomaterials have outstanding applications in biomedical areas, such as drug delivery agents, nanoparticles-based imaging, magnetic fluid hyperthermia, and tissue regeneration. In the line of extensive development in nanomaterials-aided drug delivery platforms, pharmacokinetic assessments have achieved greater consideration from scientists and ...
Somvanshi, Sandeep B., Kharat, Prashant B., Jadhav, K.M., Thorat, Nanasaheb D., Townley, Helen   +4 more
openaire   +1 more source

Physiology-based IVIVE predictions of tramadol from in vitro metabolism data [PDF]

, 2014
To predict the tramadol in vivo pharmacokinetics in adults by using in vitro metabolism data and an in vitro-in vivo extrapolation (IVIVE)-linked physiologically-based pharmacokinetic (PBPK) modeling and simulation approach (SimcypA (R)).
Allegaert, Karel, Annaert, Pieter, Boussery, Koen, Colin, Pieter, Cuyckens, Filip, Mannens, Geert, Snoeys, Jan, T'jollyn, Huybrecht, Van Bocxlaer, Jan, Van Peer, Achiel, Vermeulen, An   +10 more
core   +1 more source

Intermediate role of gut microbiota in vitamin B nutrition and its influences on human health

Frontiers in Nutrition, 2022
Vitamin B consists of a group of water-soluble micronutrients that are mainly derived from the daily diet. They serve as cofactors, mediating multiple metabolic pathways in humans.
Zhijie Wan, Jianheng Zheng, Zhigang Zhu, Lan Sang, Jinwei Zhu, Shizheng Luo, Yixin Zhao, Ruirui Wang, Yicui Zhang, Kun Hao, Liang Chen, Jun Du, Juntao Kan, Hua He   +13 more
doaj   +1 more source

Artemisinins [PDF]

, 2005
Artemisinins were discovered to be highly effective antimalarial drugs shortly after the isolation of the parent artemisinin in 1971 in China. These compounds combine potent, rapid antimalarial activity with a wide therapeutic index and an absence of ...
Haynes, RK, Krishna, S, Woodrow, CJ
core   +2 more sources

Pharmacokinetics of Cephalexin after Intravenous and Single and Multiple Intramuscular Administration to Rabbit [PDF]

, 2013
Cephalexin is a first generation cephalosporin widely used in rabbits. Its spectrum includes Pasteurella multocida and Staphylococcus aureus. These bacteria, together with Bordetella bronchiseptica, are the main cause of respiratory infections.
Albarellos, Gabriela Alejandra, Landoni, Maria Fabiana, Meneses, María Laura   +2 more
core   +2 more sources

Physiologically based pharmacokinetic modeling for development and applications of a virtual celiac disease population using felodipine as a model drug

CPT: Pharmacometrics & Systems Pharmacology, 2023
In celiac disease (CeD), gastrointestinal CYP3A4 abundance and morphology is affected by the severity of disease. Therefore, exposure to CYP3A4 substrates and extent of drug interactions is altered.
Farzaneh Salem, Ali Nimavardi, Jennypher Mudunuru, Debra Tompson, Jackie Bloomer, David B. Turner, Kunal S. Taskar   +6 more
doaj   +1 more source