Results 31 to 40 of about 628,142 (342)

Future of 5-fluorouracil in cancer therapeutics, current pharmacokinetics issues and a way forward [PDF]

, 2019
Background: In addition to exhibiting antitumor potential, antitumor drugs exhibit toxicity due to a poor pharmacokinetic profile. An enormous amount of research has been carried out and is still ongoing to obtain more targeted, potent, and safe drugs to
Abd-Rabou, Anitha, Arias, Atrián-Blasco, Berners-Price, Bertrand, Carrillo, Chandran, Chibaudel, Clingan, DiGiulio, Esin, Gao, Gasser, Hoste, Li, Liu, Liu, Luo, Miura, Mohana, Moloney, Nadzri, Nisa, Nivethaa, Nunes, Rambabu, Rengaraj, Saǧir, Shaima, Shen, Subudhi, Sun, Tummala, Wang, Yu, Zhang, Zhang, Zhu, Álvarez   +39 more
core   +1 more source

An Investigation on Glucuronidation Metabolite Identification, Isozyme Contribution, and Species Differences of GL-V9 In Vitro and In Vivo

Molecules, 2019
GL-V9 is a prominent derivative of wogonin with a wide therapeutic spectrum and potent anti-tumor activity. The metabolism characteristics of GL-V9 remain unclear.
Han Xing, Dexuan Kong, Chen Ning, Ying Kong, Chang Ren, Yujie Cheng, Hui Cai, Jubo Wang, Di Zhao, Ning Li, Xijing Chen, Zhiyu Li, Yang Lu   +12 more
doaj   +1 more source

A semimechanistic population pharmacokinetic and pharmacodynamic model incorporating autoinduction for the dose justification of TAS‐114

CPT: Pharmacometrics & Systems Pharmacology, 2022
TAS‐114 is a dual deoxyuridine triphosphatase (dUTPase) and dihydropyrimidine dehydrogenase (DPD) inhibitor expected to widen the therapeutic index of capecitabine.
Hikari Araki, Toru Takenaka, Koichi Takahashi, Fumiaki Yamashita, Kazuaki Matsuoka, Kunihiro Yoshisue, Ichiro Ieiri   +6 more
doaj   +1 more source

Metabolism of ticagrelor in patients with acute coronary syndromes. [PDF]

, 2018
© The Author(s) 2018Ticagrelor is a state-of-the-art antiplatelet agent used for the treatment of patients with acute coronary syndromes (ACS). Unlike remaining oral P2Y12 receptor inhibitors ticagrelor does not require metabolic activation to exert its ...
B Ibanez, C Varenhorst, D Alexopoulos, D Aradi, D Lindholm, D Zhou, EA Amsterdam, F Franchi, G Parodi, G Parodi, H Sillén, HS Smith, J Kubica, J Kubica, J Li, JH Cornel, JM Siller-Matula, K Butler, K Butler, K Thygesen, M Koziński, M Roffi, P Adamski, P Adamski, P Adamski, P Adamski, P Niezgoda, P Niezgoda, PG Steg, PG Steg, PT O’Gara, R Teng, R Teng, R Teng, R Teng, R Teng, R Teng, RA Lange, S Husted, S James, SE Husted, SS Brar   +41 more
core   +2 more sources

Physiologically‐Based Pharmacokinetic Modeling Approach to Predict Rifampin‐Mediated Intestinal P‐Glycoprotein Induction

CPT: Pharmacometrics & Systems Pharmacology, 2019
Physiologically‐based pharmacokinetic (PBPK) modeling is a powerful tool to quantitatively describe drug disposition profiles in vivo, thereby providing an alternative to predict drug–drug interactions (DDIs) that have not been tested clinically.
Shinji Yamazaki, Chester Costales, Sarah Lazzaro, Soraya Eatemadpour, Emi Kimoto, Manthena V. Varma   +5 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Modeling long-term longitudinal HIV dynamics with application to an AIDS clinical study

, 2009
A virologic marker, the number of HIV RNA copies or viral load, is currently used to evaluate antiretroviral (ARV) therapies in AIDS clinical trials. This marker can be used to assess the ARV potency of therapies, but is easily affected by drug exposures,
Huang, Yangxin, Lu, Tao
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Bridging the blood-brain barrier: strategies to improve delivery of biologics to tumors in the brain

Fluids and Barriers of the CNS
The unique anatomical and physiological features of the blood-brain barrier (BBB), while essential for maintenance of normal brain health, present significant challenges in development of effective therapies for neurological disorders from a drug ...
Gautham Gampa, Rahul Vadlakonda, Eric Stefanich, Amrita V. Kamath, Shraddha Sadekar, Vittal Shivva   +5 more
doaj   +1 more source

The heterogeneity among subgroups of haplogroup J influencing Alzheimer’s disease risk

Journal of Advanced Research, 2021
Introduction: The impact of mitochondrial haplogroups on Alzheimer’s disease (AD) risk has not been fully elucidated and warrants further investigation at the subgroup level.
HaoChen Liu, Yixuan Zhang, Huimin Zhao, Yanan Du, XiaoQuan Liu   +4 more
doaj   +1 more source