Results 141 to 150 of about 6,010 (176)

Evaluating Model-Based Extrapolation of Plasma Exposure for Long-Acting Injectable Products: From Single- to Multiple-Dose Trials. [PDF]

CPT Pharmacometrics Syst Pharmacol
Lubberts DE, Eleveld DJ, Verscheijden LFM, Colin PJ, Koomen JV.   +4 more
europepmc   +1 more source

Using PBPK to Simulate Target Biopredictive Dissolution Profiles for Long-Acting Injectables - Where to Begin With Critical Bioavailability Attributes? [PDF]

CPT Pharmacometrics Syst Pharmacol
Cleary H, Fotaki N, Persoons T, D'Arcy DM.   +3 more
europepmc   +1 more source

Mitigate Japan's Drug Loss With Model-Informed Drug Development. [PDF]

CPT Pharmacometrics Syst Pharmacol
Imai Y, Akatsu E, Minton SK.
europepmc   +1 more source

Preclinical Modeling and Simulation to Explore the Tissue/Plasma Exposure and Pharmacodynamic Effect of Vildagliptin in Diabetes Treatment. [PDF]

CPT Pharmacometrics Syst Pharmacol
Dias BB, Olivo LB, de Araújo BV.
europepmc   +1 more source

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Pharmacometrics in Pediatrics

Therapeutic Innovation & Regulatory Science, 2019
Pharmacometrics have advanced from compartmental analysis to noncompartmental analysis and population pharmacokinetics that require complicated mathematical programs. These sophisticated mathematical analyses determine not only the usual pharmacometric measures of clearance and volume of distribution but also the effects of covariates on these measures.
Xiaoxi Liu, Robert M. Ward
openaire   +2 more sources

Pharmacometrics in Pain Management

The Biomedical & Life Sciences Collection, 2014
© American Association of Pharmaceutical Scientists 2014 S. Schmidt, H. Derendorf (eds.), Applied Pharmacometrics, AAPS Advances in the Pharmaceutical Sciences Series 14, DOI 10.1007/978-1-4939-1304-6_18 Y. Wang () · P. Ji · J. Liu · H. Zhu Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, 10903
Yaning Wang, Jiang Liu, Hao Zhu, Ping Ji
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Pharmacometrics 2020

The Journal of Clinical Pharmacology, 2010
This special issue of the Journal of Clinical Pharmacology is dedicated to pharmacometrics, covering topics related to methodological research, application to decisions, standardization, PhRMA survey, and growth strategy. Innovative methodological and technological advances in analyzing disease, drug, and trial data have equipped pharmacometricians ...
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Clinical pharmacometrics

2021
Στις μέρες μας, η μαθηματική μοντελοποίηση έχει αποδειχθεί ότι αποτελεί ένα πολύ σημαντικό στοιχείο της κλινικής φαρμακευτικής. Στην παρούσα διατριβή, τεχνικές πληθυσμιακής μοντελοποίησης, παλινδρόμησης, προσομοίωσης και μηχανικής μάθησης εφαρμόστηκαν για την βελτιστοποίηση δoσολογικών σχημάτων, για να διερευνηθεί η επίδραση της γαστρικής κένωσης και ...
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Pharmacometrics and Systems Pharmacology 2030

Clinical Pharmacology & Therapeutics, 2019
In 2012, a new journal was launched from the ASCPT family, CPT: Pharmacometrics and Systems Pharmacology (PSP) as both quantitative system pharmacology (QSP) and pharmacometrics were growing fields in pharmacology, drug development, and drug use. In this Perspective, the present editors and associate editors of PSP want to share their strategic vision ...
France, Mentré, Lena E, Friberg, Stephen, Duffull, Jonathan, French, Douglas A, Lauffenburger, Lang, Li, Donald E, Mager, Vikram, Sinha, Eric, Sobie, Ping, Zhao   +9 more
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Pharmacometrics in Dermatology

2014
There is increasing recognition of the impact of pharmacometrics in improving drug development and influencing regulatory decision making across different therapeutic areas. However, the field of dermatology remains largely underserved by pharmacometrics with limited number of examples illustrating the application of modeling and simulation methods in ...
Vivek S. Purohit, Manisha Lamba, Pankaj Gupta   +2 more
openaire   +1 more source