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The Decline and Fall of Materia Medica and the Rise of Pharmacology and Therapeutics in Veterinary Medicine

open access: yesFrontiers in Veterinary Science, 2022
Materia Medica is a Latin term, relating to the history of pharmacy. It describes the sources (vegetable, animal and mineral), nature, preparation, and properties of substances or mixtures of substances, which were used as remedies for the treatment of ...
Peter Lees   +3 more
doaj   +1 more source

The complete chloroplast genome of Humulus lupulus cv. ‘Fubei-1’ (Rosales: Cannabaceae)

open access: yesMitochondrial DNA. Part B. Resources, 2021
Hop (Humulus lupulus) is a perennial plant with commercial values. Here, we reported the complete chloroplast genome for a local hop cultivar (Humulus lupulus cv. ‘Fubei-1’) from Xinjiang, China.
Guoping Wang   +6 more
doaj   +1 more source

A novel dammarane triterpenoid alleviates atherosclerosis by activating the LXRα pathway

open access: yesChinese Medicine, 2023
Background We have previously demonstrated that ginsenoside compound K can attenuate the formation of atherosclerotic lesions. Therefore, ginsenoside compound K has potential for atherosclerosis therapy.
Yan Huang   +7 more
doaj   +1 more source

Galangin Exhibits Neuroprotective Effects in 6-OHDA-Induced Models of Parkinson’s Disease via the Nrf2/Keap1 Pathway

open access: yesPharmaceuticals, 2022
Parkinson’s disease (PD) is the second most common neurodegenerative disease, and there is still no cure for it. PD is characterized by the degeneration of dopaminergic neurons, and oxidative stress has been considered an important pathological mechanism.
Qiu-Xu Chen   +8 more
doaj   +1 more source

An advanced network pharmacology study to explore the novel molecular mechanism of Compound Kushen Injection for treating hepatocellular carcinoma by bioinformatics and experimental verification

open access: yesBMC Complementary Medicine and Therapies, 2022
Background Compound Kushen Injection (CKI) is a Chinese patent drug that exerts curative effects in the clinical treatment of hepatocellular carcinoma (HCC).
Shan Lu   +16 more
doaj   +1 more source

A co-crystal berberine-ibuprofen improves obesity by inhibiting the protein kinases TBK1 and IKKɛ

open access: yesCommunications Biology, 2022
The co-crystal berberine-ibuprofen is an effective agent for treating obesity through a reduction of the activity of the non-canonical I κB kinases, IKKε and TBK1.
Man Wang   +8 more
doaj   +1 more source

A New Antimalarial Noreudesmane Sesquiterpenoid from Dobinea delavayi

open access: yesNatural Products and Bioprospecting, 2020
One previously undescribed angeloylated noreudesmane sesquiterpenoid, dobinin O (1), along with four known eudesmane sesquiterpenoids (2–5) were isolated from the peeled roots of Dobinea delavayi.
Xiu-Rong Wu   +5 more
doaj   +1 more source

Exploring the effect of Yinzhihuang granules on alcoholic liver disease based on pharmacodynamics, network pharmacology and molecular docking

open access: yesChinese Medicine, 2023
Background Yinzhihuang granules (YZHG) is a commonly used Chinese patent medicine for the treatment of liver disease. However, the mechanism of YZHG in alcoholic liver disease (ALD) is still unclear. Methods This study combined liquid chromatography-mass
Yingying Tan   +13 more
doaj   +1 more source

Study on Formulation, in vivo Exposure, and Passive Targeting of Intravenous Itraconazole Nanosuspensions

open access: yesFrontiers in Pharmacology, 2019
The pharmacokinetic profile of a drug can be different when delivered as a nanosuspension compared with a true solution, which may in turn affect the therapeutic effect of the drug.
Qi Yuan   +9 more
doaj   +1 more source

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