Results 71 to 80 of about 2,739,138 (153)

Cryptotanshinone inhibits PFK-mediated aerobic glycolysis by activating AMPK pathway leading to blockade of cutaneous melanoma

Chinese Medicine
Background Cutaneous melanoma is a kind of skin malignancy with low morbidity but high mortality. Cryptotanshinone (CPT), an important component of salvia miltiorrhiza has potent anti-tumor activity and also indicates therapeutic effect on dermatosis. So
Qiong Chen, Yang Liu, Yunxuan Zhu, Ziyan Zhu, Jueyao Zou, Yanhong Pan, Yin Lu, Wenxing Chen   +7 more
doaj   +1 more source

Enhancing Pharmaceutical Cold Supply Chain: Integrating Medication Synchronization and Diverse Delivery Modes [PDF]

The significance of last-mile logistics in the healthcare supply chain is growing steadily, especially in pharmacies where the growing prevalence of medication delivery to patients' homes is remarkable. This paper proposes a novel mathematical model for the last-mile logistics of the pharmaceutical supply chain and optimizes a pharmacy's logistical ...
arxiv   +1 more source

SQSTM1/p62 Orchestrates Skin Aging via USP7 Degradation

Aging Cell, EarlyView.
p62 exhibits diminished expression in aging skin and senescent cells. p62 serves to inhibit the accumulation of USP7 during senescence induction. The Tyr‐67 residue within the PB1 domain or Gln‐418 within the UBA domain of p62 forms a hydrogen bond with Ala‐993 of the Ubl5 domain of USP7.
Liu Chen, Xiaoping Wang, Yuchen Wang, Qingxin Yao, Yunyao Liu, Yongcheng Zhu, He Huang, Hedan Yang, Yin Yang, Yuan He, Lei Qiang   +10 more
wiley   +1 more source

Supporting Contraceptive Decision-Making in the Intermediated Pharmacy Setting in Kenya [PDF]

Adolescent girls and young women (AGYW) in sub-Saharan Africa face unique barriers to contraceptive access and lack AGYW-centered contraceptive decision-support resources. To empower AGYW to make informed choices and improve reproductive health outcomes, we developed a tablet-based application to provide contraceptive education and decision-making ...
arxiv   +1 more source

Involvement of Piezo 1 in inhibition of shear‐induced platelet activation and arterial thrombosis by ginsenoside Rb1

British Journal of Pharmacology, Volume 182, Issue 9, Page 1957-1974, May 2025.
Abstract Background and Purpose Shear‐induced platelet activation and aggregation (SIPA) play crucial roles in arterial thrombosis. Piezo1 is a mechanosensitive calcium channel that promotes platelet hyperactivation under pathological high‐shear conditions.
Yilin Wang, Lu Liu, Jia Li, Yue You, Shunli Xiao, Jiantao Feng, Xiaojie Yin, Fulong Liao, Yun You   +8 more
wiley   +1 more source

Identifying roles of clinical pharmacy with survey evaluation [PDF]

arXiv, 2014
The survey data sets are important sources of data and their successful exploitation is of key importance for informed policy-decision making. We present how a survey analysis approach initially developed for customer satisfaction research in marketing can be adapted for the introduction of clinical pharmacy services into hospital.
arxiv  

The chromosome‐scale assembly of the Salvia plebeia genome provides insight into the biosynthesis and regulation of rosmarinic acid

Plant Biotechnology Journal, Volume 23, Issue 5, Page 1507-1520, May 2025.
Summary Salvia plebeia is an important traditional Chinese medicinal herb, with flavonoids and phenolic acids as its primary bioactive components. However, the absence of a reference genome hinders our understanding of genetic basis underlying the synthesis of these components.
Yiqun Dai, Mengqian He, Hui Liu, Huihui Zeng, Kaixuan Wang, Rui Wang, Xiaojing Ma, Yan Zhu, Guoyong Xie, Yucheng Zhao, Minjian Qin   +10 more
wiley   +1 more source

Inhibition Peroxiredoxin‐2 by Capsaicin Ameliorates Rheumatoid Arthritis via ROS‐Mediated Apoptosis in Fibroblast‐Like Synoviocytes

MedComm, Volume 6, Issue 6, June 2025.
Capsaicin attenuating arthritis by inhibiting AKT phosphorylation and activating the NRF2–HO‐1 axis via targeting PRDX2 ABSTRACT Rheumatoid arthritis (RA), a prevalent and incurable autoimmune disease globally, is characterized by the immune system attacking the body's own tissues, leading to joint inflammation and damage.
Hengkai He, Mingjing Hao, Piao Luo, Junhui Chen, Yehai An, Jingnan Huang, Ruiyi He, Qingfeng Du, Qian Zhang, Jigang Wang   +9 more
wiley   +1 more source

GRP78 Nanobody‐Directed Immunotoxin Activates Innate Immunity Through STING Pathway to Synergize Tumor Immunotherapy

Advanced Science, Volume 12, Issue 19, May 22, 2025.
A GRP78 nanobody‐directed immunotoxin suppresses cancer progression and metastasis by enhancing antitumor immunity via STING pathway activation, offering a pan‐cancer‐targeted approach and immunotherapy combination strategy. Abstract The lack of targetable antigens poses a significant challenge in developing effective cancer‐targeted therapies.
Huifang Wang, Runhua Zhou, Chengchao Xu, Lingyun Dai, Rui Hou, Liuhai Zheng, Chunjin Fu, Guangwei Shi, Jingwei Wang, Yang Li, Jinpeng Cen, Xiaolong Xu, Le Yu, Yilei Li, Jigang Wang, Qingfeng Du, Zhijie Li   +16 more
wiley   +1 more source

Aidi injection inhibits the migration and invasion of gefitinib-resistant lung adenocarcinoma cells by regulating the PLAT/FAK/AKT pathway

Chinese Medicine
Background With extended gefitinib treatment, the therapeutic effect in some non-small cell lung cancer (NSCLC) patients declined with the development of drug resistance.
Jingyuan Zhang, Siyun Yang, Xiaodong Chen, Fanqin Zhang, Siyu Guo, Chao Wu, Tieshan Wang, Haojia Wang, Shan Lu, Chuanqi Qiao, Xiaoguang Sheng, Shuqi Liu, Xiaomeng Zhang, Hua Luo, Qinglin Li, Jiarui Wu   +15 more
doaj   +1 more source