Results 101 to 110 of about 87,708 (328)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Gravitational Wave Bursts from Collisions of Primordial Black Holes in Clusters

, 2010
The rate of gravitational wave bursts from the mergers of massive primordial black holes in clusters is calculated. Such clusters of black holes can be formed through phase transitions in the early Universe.
A. Cattaneo, A. Sesana, C. M. Will, H. Mouri, L. P. Grishchuk, L. Spitzer, M. Mapelli, M. Yu. Khlopov, M. Yu. Khlopov, S. G. Rubin, S. G. Rubin, S. G. Rubin, V. Dokuchaev, V. I. Dokuchaev, Y. Gao, Yu. N. Eroshenko   +15 more
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Flow-based nonperturbative simulation of first-order phase transitions

Journal of High Energy Physics
We present a flow-based method for simulating and calculating nucleation rates of first-order phase transitions in scalar field theory on a lattice. Motivated by recent advancements in machine learning tools, particularly normalizing flows for lattice ...
Yang Bai, Ting-Kuo Chen
doaj   +1 more source

Probing early Universe supercooled phase transitions with gravitational wave data [PDF]

, 2023
C. Badger, Bartosz Fornal, K. Martinovic, A. Romero, K. Turbang, Huai-Ke Guo, Alberto Mariotti, Mairi Sakellariadou, Alexander Sevrin, F. W. Yang, Yue Zhao   +10 more
openalex   +1 more source

The First Magnetic Fields

, 2011
We review current ideas on the origin of galactic and extragalactic magnetic fields. We begin by summarizing observations of magnetic fields at cosmological redshifts and on cosmological scales.
A. Brandenburg, A. Kosowsky, A. Lazarian, A. Lewis, A. Mack, A. Neronov, A. Rebhan, A. Yahil, A.A. Starobinskii, A.H. Guth, A.J. Keane, B. Cheng, B. Himmetoglu, B. Himmetoglu, B. Ratra, B. Schenke, B.D. Fried, C. Bonvin, C. Caprini, C. Pinto, C. Pinto, C.D. Dermer, C.G. Tsagas, C.G. Tsagas, C.G. Tsagas, C.J. Hogan, C.L. Carilli, Christos G. Tsagas, D. Grasso, D.G. Yamazaki, D.H. Lyth, D.R.G. Schleicher, D.R.G. Schleicher, D.R.G. Schleicher, D.T. Son, Dominik R. G. Schleicher, Dongsu Ryu, E. Fenu, E. Weibel, E.-J. Kim, E.W. Kolb, F. Finelli, F. Hoyle, F. Hoyle, G. Davies, G. Sigl, G.B. Field, H. Maki, H. Stefani, H. Tashiro, H. Tashiro, H. Xu, I. Brown, J. Adamek, J. Adams, J. Martin, J. Silk, J. Silk, J.-P. Blaizot, J.A. Peacock, J.A. Quashnock, J.C. Tan, J.D. Barrow, J.D. Barrow, J.D. Barrow, J.D. Jackson, J.M. Cornwall, J.R. Shaw, K. Ichiki, K. Jedamzik, K. Jedamzik, K. Subramanian, K. Subramanian, K. Subramanian, K. Subramanian, K. Subramanian, K. Subramanian, K. Subramanian, K. Takahashi, K. Thorne, K.-T. Kim, Kandaswamy Subramanian, L. Biermann, L.F.S. Rodrigues, L.M. Widrow, Lawrence M. Widrow, M. Ando, M. Christensson, M. Gasperini, M. Giovannini, M. Langer, M. Strickland, M. Strickland, M.A. Stenrup, M.J. Rees, M.J. Rees, M.L. Bernet, M.N. Machida, M.S. Turner, M.V. Penston, N.Y. Gnedin, P. Anninos, P. Arnold, P. Arnold, P. Arnold, P. Arnold, P. Arnold, P. Hennebelle, P. Hennebelle, P. Romatschke, P.J. Greenberg, P.J.E. Peebles, P.J.E. Peebles, P.P. Kronberg, P.P. Kronberg, P.P. Kronberg, R. Banerjee, R. Banerjee, R. Banerjee, R. Durrer, R. Durrer, R. Durrer, R. Durrer, R.-G. Cai, R.A. Daly, R.B. Larson, R.E. Pudritz, R.M. Athreya, R.M. Kulsrud, R.M. Kulsrud, Rudolf A. Treumann, S. Bethke, S. Seager, S. Sur, S.C.O. Glover, S.D.M. White, S.I. Syrovatskii, S.K. Sethi, S.W. Hawking, St. Mrówczyński, St. Mrówczyński, T. Abel, T. Abel, T. Kahniashvili, T. Vachaspati, T.R. Seshadri, T.R. Seshadri, U. Frisch, V. Bromm, V. Demozzi, Ya.B. Zel’dovich, Yu.E. Pokrovsky   +151 more
core   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Gravitational wave signature of generic disappearance of Z 2-symmetry breaking domain walls

Journal of High Energy Physics
Breaking of discrete parity at high scale gives rise to Z 2-domain walls (DW). The metastability of such walls can make them relatively long lived and contradict standard cosmology. We consider two classes of theories with similar underlying feature, the
Piyali Banerjee, Urjit A. Yajnik
doaj   +1 more source

Hearing the echoes of electroweak baryogenesis with gravitational wave detectors

, 2016
We report on the first joint analysis of observational signatures from the electroweak baryogenesis in both gravitational wave (GW) detectors and particle colliders.
Cai, Yi-Fu, Huang, Fa Peng, Wan, Youping, Wang, Dong-Gang, Zhang, Xinmin   +4 more
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source