Results 61 to 70 of about 87,708 (328)
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
On Topological Defects and Cosmological Constant
, 2013 Einstein introduced Cosmological Constant in his field equations in an ad hoc manner. Cosmological constant plays the role of vacuum energy of the universe which is responsible for the accelerating expansion of the universe.
Kalam, M., Rahaman, F., Raychaudhuri, B.
core +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Have pulsar timing arrays detected the hot big bang: Gravitational waves from strong first order phase transitions in the early Universe [PDF]
, 2022 Katherine Freese +1 more
openalex +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Journal of High Energy PhysicsWe perform real-time hydrodynamical simulations of the growth of bubbles formed during cosmological first-order phase transitions under the assumption of local thermal equilibrium.
Tomasz Krajewski +2 more
doaj +1 more source
Decoherence of cosmological perturbations from boundary terms and the non-classicality of gravity
Journal of High Energy Physics, 2023 We note that the decoherence of inflationary curvature perturbation ζ is dominated by a boundary term of the gravity action. Although this boundary term cannot affect cosmological correlators 〈ζ n 〉, it induces much faster decoherence for ζ than that of ...
Chon Man Sou, Duc Huy Tran, Yi Wang
doaj +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Non-linearities in cosmological bubble wall dynamics
Journal of High Energy PhysicsA precise modelling of the dynamics of bubbles nucleated during first-order phase transitions in the early Universe is pivotal for a quantitative determination of various cosmic relics, including the stochastic background of gravitational waves.
Stefania De Curtis +4 more
doaj +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source