Results 61 to 70 of about 4,163 (286)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Steady-state bubbles beyond local thermal equilibrium

Journal of High Energy Physics
We investigate the hydrodynamic solutions for expanding bubbles in cosmological first-order phase transitions going beyond local thermal equilibrium approximation.
Tomasz Krajewski, Marek Lewicki, Ignacy Nałęcz, Mateusz Zych   +3 more
doaj   +1 more source

Decoherence of cosmological perturbations from boundary terms and the non-classicality of gravity

Journal of High Energy Physics, 2023
We note that the decoherence of inflationary curvature perturbation ζ is dominated by a boundary term of the gravity action. Although this boundary term cannot affect cosmological correlators 〈ζ n 〉, it induces much faster decoherence for ζ than that of ...
Chon Man Sou, Duc Huy Tran, Yi Wang
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Phase transition and gravitational waves in maximally symmetric composite Higgs model

Journal of High Energy Physics
In this paper we study phase transitions in a maximally symmetric composite Higgs model with next-to-minimal coset, where a pseudoscalar singlet emerges alongside the Higgs doublet.
Avik Banerjee, Marco Merchand, Ignacy Nałęcz   +2 more
doaj   +1 more source

Quark confinement and phase transition in the early universe

Physics Letters B, 1985
Abstract In the context of the hadronic phase transition in the early universe, the Plumer-Raha-Weiner model for quark confinement is found to limit the bag constant B to the narrow range (170 MeV) 4 –(190 MeV) 4 for an assumed transition temperature of 200 MeV.
V.V. Dixit, J. Lodenqual
openaire   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Conformal phase transition in supersymmetric QCD

Journal of High Energy Physics
We construct a four-dimensional supersymmetric QCD in conformal window with a marginally relevant deformation which triggers the spontaneous breaking of (approximate) scale invariance and the subsequent confinement, generating a mass gap, at an energy ...
Kohei Fujikura, Shota Nakagawa, Yuichiro Nakai, Peng Sun, Yufei Zhang   +4 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source