Results 121 to 130 of about 6,861,845 (296)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Colony morphotype variation in Burkholderia: implications for success of applications and therapeutics

Journal of Bacteriology
The Burkholderia genus includes both environmental and pathogenic isolates known for their phenotypic plasticity and adaptability. Burkholderia spp. are intrinsically resistant to many antibiotics, often requiring prolonged therapies during infection.
Pauline M. L. Coulon, Kirsty Agnoli, Garry S. A. Myers   +2 more
doaj   +1 more source

Design of a K-band Low Insertion Loss Variation Phase Shifter Using 0.18- μm CMOS Process

, 2013
[[abstract]]This paper demonstrates a k-band low insertion loss variation phase shifter with over 330° continuously phase tuning range from 21-25GHz in standard 0.18-μm CMOS technology.
Chung-Han Wu;Wei-Tsung Li;Jeng-Han Tsai;Tian-Wei Huang
core  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

A fault line selection method for flexible grounding systems based on zero-sequence current phase variation

Zhejiang dianli
To address the poor tolerance to transitional resistance and incomplete utilization of fault information in grounding protection for flexible grounding systems， a fault line selection method based on current phase variation is proposed.
LI Zong, WANG Deqiang, FENG Liang, SONG Jianguo, GAO Weiyuan, YUAN Pengsheng   +5 more
doaj   +1 more source

Sharp phase variations from the plasmon mode causing the Rabi-analogue splitting

Nanophotonics, 2017
The Rabi-analogue splitting in nanostructures resulting from the strong coupling of different resonant modes is of importance for lasing, sensing, switching, modulating, and quantum information processes.
Wang Yujia, Sun Chengwei, Gan Fengyuan, Li Hongyun, Gong Qihuang, Chen Jianjun   +5 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source