Results 141 to 150 of about 6,861,845 (296)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Genome-scale dissection of phase-variable gene function in Campylobacter jejuni using a stabilized phasotype library

mSphere
Phase variation (PV) allows bacterial pathogens to rapidly modify surface structures through reversible mutations—often driven by simple sequence repeats (SSRs)—thereby facilitating immune evasion and environmental adaptation.
Shouji Yamamoto, Ken-ichi Lee, Akiko Kubomura, Sunao Iyoda, Yukihiro Akeda, Takaaki Shimohata, Chihiro Aikawa, Masashi Okamura, Fuhito Hojo, Takako Osaki, Jiro Mitobe   +10 more
doaj   +1 more source

Biological variation of laboratory analytes based on the 1999-2002 National Health and Nutrition Examination Survey [PDF]

"OBJECTIVE: Biological variation consists of within-person (WP) and between-person (BP) variation. These components of biological variation are used to set analytical goals for imprecision and bias, evaluate serial changes for individual analytes, and ...

core  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Profiling of Burkholderia pseudomallei variants derived from Queensland’s clinical isolates

Microbiology Spectrum
Burkholderia pseudomallei (Bp), an environmental bacterium and opportunistic pathogen endemic to tropical regions, is highly adaptive and thrives in diverse environments, from soil to human hosts.
Pauline M. L. Coulon, Kay Ramsay, Aven Lee, Edita Ritmejeryte, Miranda E. Pitt, Joyce To, Daniel G. Mediati, Ian Gassiep, Sarah Reed, Patrick N. A. Harris, Garry S. A. Myers   +10 more
doaj   +1 more source

Phase variation as a major mechanism of adaptation in <i>Mycobacterium tuberculosis</i> complex. [PDF]

Proc Natl Acad Sci U S A, 2023
Vargas R, Luna MJ, Freschi L, Marin M, Froom R, Murphy KC, Campbell EA, Ioerger TR, Sassetti CM, Farhat MR.   +9 more
europepmc   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Phase variation of manganese oxide in the MnO@ZnO nanocomposite with calcination temperature and its effect on structural and biological activities. [PDF]

Sci Rep, 2023
Basak S, Haydar MS, Sikdar S, Ali S, Mondal M, Shome A, Sarkar K, Roy S, Roy MN.   +8 more
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Amplitude-Phase Variation in a Graphene-Based Microstrip Line. [PDF]

Micromachines (Basel), 2022
Yasir M, Fatikow S, Haenssler OC.
europepmc   +1 more source