Results 161 to 170 of about 6,861,845 (296)

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

open access: yesFEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Linguistic Variation and Change

open access: yes
A comprehensive study of variation and change, including current debates in the area.Intro -- Cover -- Copyright -- Contents -- Figures -- Tables -- Preface and acknowledgements -- Terminology and notation conventions -- Phonetic notation -- Part I ...
Kiesling, Scott F.
core  

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

Estimating the phase congruency of localised frequencies

open access: yes, 2004
Phase congruency is a new method for detecting features in images. One of its significant strengths is its invariance to lighting variation within an image, as well as being able to detect a wide range of interesting features.
Myerscough, Peter J, Nixon, Mark S
core   +1 more source

Epigenetic phase variation in the gut microbiome enhances bacterial adaptation. [PDF]

open access: yesCell Host Microbe
Ni M   +14 more
europepmc   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Analysing Variation in English

open access: yes
This book brings together a range of perspectives on the collection, analysis and broader relevance of variable language data.Cover -- Half-title -- Title -- Copyright -- Contents -- Figures -- Tables -- Contributors -- Abbreviations -- Corpora and tools
McMahon, April., Maguire, Warren.
core  

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