Ferroptosis in sepsis induced acute lung injury/acute respiratory distress syndrome (ALI/ARDS): a potential therapeutic strategy. [PDF]
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A highly photostable monomeric red fluorescent protein for dual-color 3D STED and time-lapse 3D SIM imaging. [PDF]
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PHB2 Maintains the Contractile Phenotype of VSMCs by Counteracting PKM2 Splicing
Circulation Research, 2022Background: Phenotypic transition of vascular smooth muscle cells (VSMCs) accounts for the pathogenesis of a variety of vascular diseases during the early stage. Recent studies indicate the metabolic reprogramming may be involved in VSMC phenotypic transition.
Yiting Jia +16 more
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Tetrahydroberberrubine retards heart aging in mice by promoting PHB2-mediated mitophagy
Acta Pharmacologica Sinica, 2022Heart aging is characterized by left ventricular hypertrophy and diastolic dysfunction, which in turn induces a variety of cardiovascular diseases. There is still no therapeutic drug to ameliorate cardiac abnormities in heart aging. In this study we investigated the protective effects of berberine (BBR) and its derivative tetrahydroberberrubine (THBru)
Lei, Wang +15 more
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ASURA (PHB2) Interacts with Scc1 through Chromatin
Cytogenetic and Genome Research, 2013Sister chromatid cohesion mediated by the cohesin complex is essential for faithful chromosome segregation. Previously we reported that PHB2 (prohibitin2/ASURA), a multifunctional protein, has a role in sister chromatid cohesion. Nevertheless, how ASURA is involved in sister chromatid cohesion still remains unclear.
I, Equilibrina +5 more
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PHB2 interacts with RNF2 and represses CP2c-stimulated transcription
Molecular and Cellular Biochemistry, 2008RNF2, a polycomb group protein, is an important component of PRC complex regulating transcriptional activity. Recently, several RNF2 interacting proteins have been identified. Thus, RNF2 might have multiple activities, depending on its interacting partner proteins.
Sun-Joo, Lee +6 more
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The expression of PHB2 in the cochlea: Possible relation to age‐related hearing loss
Cell Biology International, 2021AbstractAge‐related hearing loss (ARHL) is the most prevalent sensory deficit in the elderly, but its mechanism remains unclear. Scaffold protein prohibitin 2 (PHB2) has been widely involved in aging and neurodegeneration. However, the role of PHB2 in ARHL is undeciphered to date.
Xiaoyu Yu +8 more
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Study on the Role of Mitophagy Receptor PHB2 in Doubly Uniparental Inheritance of Hyriopsis cumingii
Marine Biotechnology, 2023In bivalves, the heterogeneity of mitochondrial DNA and its unique mode of transmission have been the focus of attention, which is called doubly uniparental inheritance (DUI). Prohibitin-2 (phb2) is a mitochondrial inner membrane protein that is a key mitophagy receptor for parental mitochondrial removal.
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