Results 161 to 170 of about 4,972 (216)

Phenanthridines

ChemInform, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
openaire   +1 more source

Antimalarial benzo[c]phenanthridines

Bioorganic & Medicinal Chemistry Letters, 2005
Analogues of the antimalarial alkaloid nitidine have been prepared with high potency against both chloroquine-sensitive and -resistant strains of Plasmodium falciparum in vitro. Simple modifications, using an established synthetic route, resulted in an analogue with IC(50) below 5ng/mL against a chloroquine-sensitive strain of P. falciparum.
Susan L. Sharples, Eddie K. Mberu, James M. Nyangulu, Samantha L. Hargreaves, Simon P. Mackay, Roger D. Waigh, William M. Watkins, William M. Watkins, Olivier Duval   +8 more
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Cascade π-Extended Decarboxylative Annulation Involving Cyclic Diaryliodonium Salts: Site-Selective Synthesis of Phenanthridines and Benzocarbazoles via a Traceless Directing Group Strategy.

Organic Letters, 2019
A novel cascade π-extended decarboxylative annulation (PEDA) involved with cyclic diaryliodonium salts is described. Via fine-tuning of the reaction conditions, the Pd(II)-catalyzed site-selective N1/C2 or C2/C3 annulation of commercially available ...
Zenghui Ye, Yong Li, Kai Xu, N. Chen, Fengzhi Zhang   +4 more
semanticscholar   +1 more source

Photocatalytic xanthate-based radical addition/cyclization reaction sequence toward 2-biphenyl isocyanides: synthesis of 6-alkylated phenanthridines.

Organic and biomolecular chemistry, 2020
A photocatalytic xanthate-based radical addition/cyclization reaction cascade toward 2-biphenylisocyanides is described as a practical and modular approach to 6-alkylated phenanthridines.
Pedro López-Mendoza, L. D. Miranda
semanticscholar   +1 more source

Expeditious synthesis of phenanthridines through a Pd/MnO2-mediated C-H arylation/oxidative annulation cascade from aldehydes, aryl iodides and amino acids.

Chemical Communications, 2020
The expeditious construction of phenanthridine scaffolds via a Pd/MnO2-mediated C-H arylation/oxidative annulation cascade involving aldehydes, aryl iodides and amino acids is disclosed. This reaction proceeds smoothly involving the formation of multiple
Jian Fan, Li Li, Jitan Zhang, M. Xie
semanticscholar   +1 more source

Acridities and phenanthridines

2020
The acridine and phenanthridine chromophores both contain a central six-membered aromatic nitrogen heterocycle, with benzo rings fused onto each side. Although sulfonated and hydroxylated acridines have been synthesized, none are used as stains. The hydrophilic/lipophilic properties of the dyes under usage conditions are varied.
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DPP-IV Inhibitory Phenanthridines: Ligand, Structure-Based Design, and Synthesis.

Current Computer - Aided Drug Design, 2020
BACKGROUND Lately, diabetes has become a main health concern for millions of people around the world. Dipeptidyl peptidase-IV (DPP-IV) inhibitors have emerged as a new class of oral antidiabetic agents.
R. A. Khalaf, Dalal Masalha, D. Sabbah
semanticscholar   +1 more source

SYNTHESES INVOLVING IMIDOGEN INTERMEDIATES: PHENANTHRIDINES AND BENZO[c]PHENANTHRIDINES

Canadian Journal of Chemistry, 1963
not available
G. Tertzakian, D. Newman, Rudolph A. Abramovitch   +2 more
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A Review on Synthetic Approaches of Phenanthridine

Letters in Organic Chemistry, 2022
Abstract:The phenanthridine family is widely found in medicinal chemistry and material science because of the biological activity and its presence in a variety of significant natural products and synthetic dye stuffs. The phenanthridine has many clinical applications, for e.g., being used as an anticancer agent, possessing antibacterial, antiprotozoal,
Nilesh Kshirsagar, Ratnamala Sonawane, Sultan Pathan, Ganesh Kamble, Girdhar Pal Singh   +4 more
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Visible-Light-Mediated Tandem Sulfonylation/Cyclization of Vinyl Azides with Sulfonyl Hydrazines for the Synthesis of 6-(Sulfonylmethyl)phenanthridines under Mild Conditions

Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry, 2019
A visible-light-mediated tandem sulfonylation/cyclization of vinyl azides with sulfonyl hydrazines was developed that provides an efficient and simple strategy for the synthesis of valuable 6-(sulfonylmethyl)phenanthridines with a broad substrate scope ...
L. Mao, Lifen Quan, Xianjin Zhu, Cong‐Bin Ji, An-Xi Zhou, Fayun Chen, D. Zheng   +6 more
semanticscholar   +1 more source