Results 11 to 20 of about 28,135 (323)

Oral administration of Ketamir-2, a novel ketamine analog, attenuates neuropathic pain in rodent models via selective NMDA antagonism [PDF]

Frontiers in Pharmacology
Ketamir-2 is a novel ketamine analog with improved oral bioavailability and superior safety profile compared to existing ketamine treatments of pain. It is a low-affinity N-methyl-D-aspartic acid (NMDA) receptor antagonist, which selectively binds to the
Itzchak Angel, Rita Perelroizen, Eddy Pichinuk, Erez Aminov   +3 more
doaj   +2 more sources

Reassessment of amphetamine- and phencyclidine-induced locomotor hyperactivity as a model of psychosis-like behavior in rats [PDF]

Journal of Integrative Neuroscience, 2022
Locomotor hyperactivity induced by psychotomimetic drugs, such as amphetamine and phencyclidine, is widely used as an animal model of psychosis-like behaviour and is commonly attributed to an interaction with dopamine release and N-methyl-D-aspartate (
Snezana Kusljic, Maarten van den Buuse, Andrea Gogos   +2 more
doaj   +1 more source

Effects of Long-term antipsychotic treatment on enkephalin-immunoreactive neurons in rats perinatally treated with phencyclidine [PDF]

Medicinski Podmladak, 2023
Introduction: Schizophrenia is a chronic mental illness that affects 1% of the world's population. The phencyclidine animal model of schizophrenia is based on the glutamate theory of the development of schizophrenia.
Kompanijec Anja, Korica Bojan, Stojković Tihomir   +2 more
doaj   +1 more source

Modified climbing fiber/Purkinje cell synaptic connectivity in the cerebellum of the neonatal phencyclidine model of schizophrenia

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance Synaptogenesis and neural network remodeling are at their maximum during the perinatal period of human brain development. Perturbations of this highly sensitive stage might underlie the etiology of neurodevelopmental disorders.
M. Veleanu, Beetsi Urrieta-Chávez, S. Sigoillot, Maela A. Paul, A. Usardi, K. Iyer, Marine Delagrange, J. Doyle, N. Heintz, C. Bécamel, F. Selimi   +10 more
semanticscholar   +1 more source

Synthesis and characterization of phencyclidine and his derivatives [PDF]

Hemijska Industrija, 2010
Phencyclidine (PCP) or 1-phenyl-cyclohexylpiperidine is the best known representative drug from the compound class of arylcyclohexylamines. On an account of pharmacological activities it belongs to the family of drugs known as a dissociative anesthetics.
Ilić Nataša C., Marinković Aleksandar D., Brkić Danijela V., Petrović Slobodan D.   +3 more
doaj   +1 more source

Neural substrates of cognitive impairment in a NMDAR hypofunction mouse model of schizophrenia and partial rescue by risperidone

Frontiers in Cellular Neuroscience, 2023
N-methyl D-aspartate receptor (NMDAR) hypofunction is a pathophysiological mechanism relevant for schizophrenia. Acute administration of the NMDAR antagonist phencyclidine (PCP) induces psychosis in patients and animals while subchronic PCP (sPCP ...
Cristina Delgado-Sallent, Thomas Gener, Thomas Gener, Thomas Gener, Pau Nebot, Cristina López-Cabezón, Cristina López-Cabezón, M. Victoria Puig, M. Victoria Puig, M. Victoria Puig   +9 more
doaj   +1 more source

Phenotypical Screening on Neuronal Plasticity in Hippocampal-Prefrontal Cortex Connectivity Reveals an Antipsychotic with a Novel Profile

Cells, 2022
Dysfunction in the hippocampus-prefrontal cortex (H-PFC) circuit is a critical determinant of schizophrenia. Screening of pyridazinone-risperidone hybrids on this circuit revealed EGIS 11150 (S 36549). EGIS 11150 induced theta rhythm in hippocampal slice
Michael Spedding, Claude Sebban, Thérèse M. Jay, Cyril Rocher, Brigitte Tesolin-Decros, Paul Chazot, Esther Schenker, Gabor Szénási, György I. Lévay, Katalin Megyeri, Jozsef Barkóczy, Laszlo G. Hársing, Ian Thomson, Mark O. Cunningham, Miles A. Whittington, Lori-An Etherington, Jeremy J. Lambert, Ferenc A. Antoni, Istvan Gacsályi   +18 more
doaj   +1 more source

P2X7 Receptor-Dependent Layer-Specific Changes in Neuron-Microglia Reactivity in the Prefrontal Cortex of a Phencyclidine Induced Mouse Model of Schizophrenia

Frontiers in Molecular Neuroscience, 2020
Background: It has been consistently reported that the deficiency of the adenosine triphosphate (ATP) sensitive purinergic receptor P2X7 (P2X7R) ameliorates symptoms in animal models of brain diseases.Objective: This study aimed to investigate the role ...
Stefano Calovi, Stefano Calovi, Paula Mut-Arbona, Paula Mut-Arbona, Pál Tod, András Iring, Annette Nicke, Susana Mato, Susana Mato, Susana Mato, Susana Mato, E. Sylvester Vizi, Jan Tønnesen, Jan Tønnesen, Beata Sperlagh   +14 more
doaj   +1 more source

Hippocampal serotonin depletion unmasks differences in the hyperlocomotor effects of phencyclidine and MK-801: quantitative versus qualitative analyses

Frontiers in Pharmacology, 2013
Antagonism of N-methyl-D-aspartate (NMDA) receptors by phencyclidine is thought to underlie its ability to induce a schizophrenia-like syndrome in humans, yet evidence indicates it has a broader pharmacological profile.
Wendy K Adams, Wendy K Adams, Adam eHalberstadt, Maarten eVan Den Buuse   +3 more
doaj   +1 more source

Reduction in phencyclidine induced sensorimotor gating deficits in the rat following increased system xc − activity in the medial prefrontal cortex

Psychopharmacology, 2012
Victoria Lutgen, Krista J. Qualmann, Jon M. Resch, Linghai Kong, SuJean Choi, David L. Baker   +5 more
openalex   +3 more sources