Results 21 to 30 of about 28,135 (323)
European Psychiatry, 2023 Introduction Zebrafish (Danio rerio) has evolved over the years as a preferred organism due to its vast repertoire in research fields that mimic a targeted phenotype, particularly behavioral typologies and specific attributes comparable to murine models
I. B. Nita +5 more
doaj +1 more source
Neurobiology of Disease, 2004 Acute phencyclidine induces schizophrenia-like symptoms in healthy humans and psychotic episodes in schizophrenics. Although phencyclidine is known as a N-methyl d-aspartate receptor antagonist (NMDA-R), the molecular events underlying the behavioral ...
Sergio Kaiser +7 more
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Journal of Psychopharmacology, 2019 Background: Cognitive deficits and structural brain changes co-occur in patients with schizophrenia. Improving our understanding of the relationship between these is important to develop improved therapeutic strategies. Back-translation of these findings
Nazanin Doostdar +5 more
semanticscholar +1 more source
Pridopidine Reverses Phencyclidine-Induced Memory Impairment
Frontiers in Pharmacology, 2018 Pridopidine is in clinical trials for Huntington's disease treatment. Originally developed as a dopamine D2 receptor (D2R) ligand, pridopidine displays about 100-fold higher affinity for the sigma-1 receptor (sigma-1R).
Kristoffer Sahlholm +7 more
doaj +1 more source
Health disparities in chronic liver disease
Hepatology, EarlyView., 2022 Abstract The syndemic of hazardous alcohol consumption, opioid use, and obesity has led to important changes in liver disease epidemiology that have exacerbated health disparities. Health disparities occur when plausibly avoidable health differences are experienced by socially disadvantaged populations.
Ani Kardashian +3 more
wiley +1 more source
Journal of Pharmacological Sciences, 2010 Parishin C, a major component of Gastrodia elata BLUME (GE), was purified from GE. Because GE modulates the serotonergic system and the 5-HT1A receptor is an important therapeutic target of schizophrenia, we examined whether parishin C affects ...
Eun-Joo Shin +10 more
doaj +1 more source
Journal of Anaesthesiology Clinical Pharmacology, 2021 Ketamine, a phencyclidine derivative and N-methyl-D-aspartate (NMDA) receptor antagonist, is widely used as an anesthetic, analgesic, and sedative agent in daily pediatric practice.
Konstantina Kalopita +4 more
doaj +1 more source
Angewandte Chemie, EarlyView.An intrinsic structure–property relationship in through‐space conductive MOFs is investigated using a series of counterion‐free porous molecular conductors (PMC‐3) with carrier‐doped π‐stacked columns. The constant carrier density and halide‐dependent tunable π‐stacking geometry in PMC‐3 enable the discovery of a linear correlation between the lattice ...
Liyuan Qu +10 more
wiley +2 more sources
Frontiers in Behavioral Neuroscience, 2018 PAOPA, a potent analog of prolyl-leucyl-glycinamide, has shown therapeutic potential at the preclinical stage for dopaminergic related illnesses, including animal models of schizophrenia, Parkinson’s disease and haloperidol-induced extrapyramidal ...
Ritesh P. Daya +7 more
doaj +1 more source
Double E─H Bond Activation of Ammonia and Water by Cyclic Gallaphosphene L(OCP)GaPGaL
Angewandte Chemie, EarlyView.Cyclic gallaphosphene 1 undergoes a twofold E─H bond activation with ammonia and water via a beneficial interplay between the polar “GaPGa” unit and the electrophilic nature of the C center in the bridging PCO unit, yielding six‐membered heterocycles 2 and 3, in which both nucleophilic phosphorus atoms are protonated.
Mahendra K. Sharma +3 more
wiley +2 more sources