Results 61 to 70 of about 28,135 (323)

Differential sensitivity of midline development to mitosis during and after primitive streak extension

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Background Midline establishment is a fundamental process during early embryogenesis for Bilaterians. Midline morphogenesis in non‐amniotes can occur without mitosis, through Planar Cell Polarity (PCP) signaling. By contrast, amniotes utilize both cellular processes for developing the early midline landmark, the primitive streak (PS).
Zhiling Zhao, Rieko Asai, Takashi Mikawa
wiley   +1 more source

Identification of a New Psychoactive Substances of Phencyclidine-type, 2-Oxo-PCPr in Seized e-Cigarette Oil

open access: yesZhipu Xuebao
The new psychoactive substances (NPSs) are defined as a category of substances of abuse, either in a pure form or a preparation, that are not listed in the control table by the 1961 Single Convention on Narcotic Drugs or the 1971 Convention on ...
Jia-lei WU   +6 more
doaj   +1 more source

Comparison of the efficacy of two anticonvulsants, phenytoin and valproate to improve PCP and d-amphetamine induced deficits in a reversal learning task in the rat

open access: yesFrontiers in Behavioral Neuroscience, 2009
Recent studies in our laboratory have shown that PCP (phencyclidine) and d-amphetamine induce a cognitive deficit in rats, in a paradigm of potential relevance for the pathology of schizophrenia.
Nagi F Idris   +2 more
doaj   +1 more source

Robinow syndrome DVL1 variants disrupt morphogenesis and appendage formation in a Drosophila disease model

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Background Robinow syndrome is a rare developmental syndrome caused by variants in genes in Wnt signaling pathways. We previously showed that expression of patient variants in Dishevelled 1 (DVL1) in Drosophila and chicken models disrupts the balance of canonical and non‐canonical Wnt signaling.
Gamze Akarsu   +4 more
wiley   +1 more source

Inducible nitric oxide inhibitors block NMDA antagonist-stimulated motoric behaviors and medial prefrontal cortical glutamate efflux

open access: yesFrontiers in Pharmacology, 2015
Nitric oxide (NO) plays a critical role in the motoric and glutamate releasing action of N-methyl-D-aspartate (NMDA)-antagonist stimulants. Earlier studies utilized neuronal nitric oxide synthase inhibitors (nNOS) for studying the neurobehavioral effects
Hadley C Bergstrom   +3 more
doaj   +1 more source

Pathogenesis and potential therapeutic targets of trichorhinophalangeal syndrome; lessons obtained from animal studies

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Trichorhinophalangeal syndrome (TRPS) is a rare genetic disease inherited in an autosomal dominant manner. It occurs in 1 in 100,000 people globally and is caused by several types of mutations of the TRPS1 gene. Since the first human patient was reported in 1966, typical and atypical pathologies, disease courses, and treatment case ...
Naoya Saeki   +6 more
wiley   +1 more source

Photoelectrochemical Charge Excitation Enhancement by Triboelectric Nanogenerator for High‐Efficiency Self‐Powered Anticorrosion

open access: yesENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
The synergy of solar and mechanical energy enables a self‐powered photoelectrochemical cathodic protection system, which enhances carrier separation for efficient and sustainable anticorrosion. Harnessing the synergy of solar and mechanical energy presents a potential strategy for high‐efficiency photoelectrochemical cathodic protection.
Youbo Nan   +6 more
wiley   +1 more source

Preparation of the Phencyclidine Analogues (Part II) [PDF]

open access: yesIranian Journal of Chemistry & Chemical Engineering, 1993
Using a-tetralone, as starting material, a series of phencyclidine analogues were synthesized. This ketone was reacted separately with ethylmagnesium bromide, P-methoxyphenylmagnesium bromide and P-methylphenylmagnesium bromide.
Mohammad Raouf Darvich, Afsaneh Zonoozi
doaj  

Transcriptional changes common to human cocaine, cannabis and phencyclidine abuse.

open access: yesPLoS ONE, 2006
A major goal of drug abuse research is to identify and understand drug-induced changes in brain function that are common to many or all drugs of abuse. As these may underlie drug dependence and addiction, the purpose of the present study was to examine ...
Elin Lehrmann   +8 more
doaj   +1 more source

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