Phenelzine and Amoxapine Inhibit Tyramine and d-Glucuronic Acid Catabolism in Clinically Significant Salmonella in A Serotype-Independent Manner [PDF]
Pathogens, 2021 Non-typhoidal Salmonella ingeniously scavenges energy for growth from tyramine (TYR) and d-glucuronic acid (DGA), both of which occur in the host as the metabolic byproducts of the gut microbial metabolism. A critical first step in energy scavenging from
Raquel Burin, Devendra H. Shah
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Enhancing immunotherapy efficacy in NSCLC through the combined use of phenelzine and Akkermansia muciniphila to regulate gut microbial metabolite 5-HIAA [PDF]
Journal for ImmunoTherapy of CancerBackground Improving the efficacy of anti-programmed death 1 (PD-1) monoclonal antibody (mAb) therapy remains a major challenge for cancer immunotherapy in non-small cell lung cancer (NSCLC). Gut microbial metabolites can influence immunotherapy efficacy.
Jie Zhao +18 more
doaj +4 more sources
Anaesthesia, 1986 Summary A 46‐year‐old female with severe phenelzine poisoning was managed successfully by alpha blockade and fluid loading, with the aid of invasive haemodynamic monitoring. The pathophysiology was documented, showing elevated plasma and urinary catecholamines, cardiovascular abnormalities and a contracted blood volume.
F X, Breheny, G J, Dobb, G M, Clarke
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Serotonin Availability Shapes the Effects of Phenelzine on Inflammatory Response and Gene Expression in Macrophages. [PDF]
CureusBackground Serotonin (5-HT) is a neurotransmitter with extensive physiological influence in the central nervous system (CNS) and various behavioral and biological functions, including immune regulation through 5-HT receptors (5-HTRs) expressed by immune ...
Mahdianipur S +5 more
europepmc +2 more sources
The prescriber’s guide to classic MAO inhibitors (phenelzine, tranylcypromine, isocarboxazid) for treatment-resistant depression [PDF]
CNS Spectrums, 2022 This article is a clinical guide which discusses the “state-of-the-art” usage of the classic monoamine oxidase inhibitor (MAOI) antidepressants (phenelzine, tranylcypromine, and isocarboxazid) in modern psychiatric practice.
Vincent Van den Eynde +43 more
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Nature Communications, 2020 Castration resistant prostate cancer patients treated with enzalutamide may develop resistance to the drug. Here, the authors report that monoamine oxidase-A expression is increased in these resistant tumors and that the antidepressants phenelzine ...
Keliang Wang +14 more
doaj +2 more sources
Oral Phenelzine Treatment Mitigates Metabolic Disturbances in Mice Fed a High-Fat Diet [PDF]
Journal of Pharmacology and Experimental Therapeutics, 2019 Novel mechanisms and health benefits have been recently suggested for the antidepressant drug phenelzine (PHE), known as a nonselective monoamine oxidase inhibitor.
Josep Mercader +7 more
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Tobacco Induced Diseases, 2018 Background Current smoking cessation methods are primarily based on the theory that nicotine is the principal addicting compound overlooking the contribution of the monoamine oxidase inhibitors present in tobacco. Our study tests the hypothesis that the
Claude A. Curran +4 more
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Network-based drug repurposing for potential stroke therapy [PDF]
Computational and Structural Biotechnology Journal, 2023 Stroke is the leading cause of death and disability worldwide, with a growing number of incidences in developing countries. However, there are currently few medical therapies for this disease.
Qihui Wu +5 more
doaj +2 more sources
Phase 2 trial of monoamine oxidase inhibitor phenelzine in biochemical recurrent prostate cancer
Prostate Cancer and Prostatic Diseases, 2020 Purpose Monoamine oxidase A (MAOA) influences prostate cancer growth and metastasis in pre-clinical models. We examined effects of phenelzine (a monoamine oxidase inhibitor) in patients with biochemical recurrent castrate-sensitive prostate cancer ...
Mitchell E. Gross +7 more
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