Phenformin activates ER stress to promote autophagic cell death via NIBAN1 and DDIT4 in oral squamous cell carcinoma independent of AMPK [PDF]
International Journal of Oral ScienceThe efficient clinical treatment of oral squamous cell carcinoma (OSCC) is still a challenge that demands the development of effective new drugs. Phenformin has been shown to produce more potent anti-tumor activities than metformin on different tumors ...
Dexuan Zhuang +10 more
doaj +3 more sources
Dual Inhibition of Pirarubicin-Induced AKT and ERK Activations by Phenformin Sensitively Suppresses Bladder Cancer Growth [PDF]
Frontiers in Pharmacology, 2019 Activations of Akt or ERK pathway induced by clinical drugs promote therapeutic failure due to decrease of drug response, and no available strategies have been developed to solve these problems.
Mei Peng +9 more
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Progress in antitumor mechanisms and applications of phenformin (Review). [PDF]
Oncol RepPhenformin, a biguanide compound, has attracted increased attention due to its prominent antitumor activity. As a multi-target agent, the antitumor effects of phenformin involve a wide range of factors, including inhibition of mitochondrial complex I ...
Zhong Q, Li D, Yang XP.
europepmc +4 more sources
Metabolic modeling elucidates phenformin and atpenin A5 as broad-spectrum antiviral drugs against RNA viruses [PDF]
Communications BiologyThe SARS-CoV-2 pandemic has reemphasized the urgent need for broad-spectrum antiviral therapies. We developed a computational workflow using scRNA-Seq data to assess cellular metabolism during viral infection. With this workflow we predicted the capacity
Alina Renz +19 more
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Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation [PDF]
Cell Reports, 2019 Summary: AMPK acts downstream of the tumor suppressor LKB1, yet its role in cancer has been controversial. AMPK is activated by biguanides, such as metformin and phenformin, and metformin use in diabetics has been associated with reduced cancer risk ...
Diana Vara-Ciruelos +9 more
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Improved pH-Responsive Release of Phenformin from Low-Defect Graphene Compared to Graphene Oxide
ACS Omega, 2021 Graphene-based drug carriers provide a promising addition to current cancer drug delivery options. Increased accessibility of high-quality graphene made by plasma-enhanced chemical vapor deposition (PE-CVD) makes it an attractive material to revisit in ...
Abdelnour Alhourani +4 more
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Cells, 2022 The treatment of many skin inflammation diseases, such as psoriasis and atopic dermatitis, is still a challenge and inflammation plays important roles in multiple stages of skin tumor development, including initiation, promotion and metastasis ...
Guanyi Liu +12 more
doaj +2 more sources
Phase Ib Trial of Phenformin in Patients with V600-mutated Melanoma Receiving Dabrafenib and Trametinib. [PDF]
Cancer Res Commun, 2023 Purpose: Preclinical studies show that activation of AMP kinase by phenformin can augment the cytotoxic effect and RAF inhibitors in BRAF V600-mutated melanoma.
Chapman PB +11 more
europepmc +2 more sources
Frontiers in Oncology, 2022 Exosomes secreted by cancer cells are important components in the tumor microenvironment, enabling cancer cells to communicate with each other and with noncancerous cells to play important roles in tumor progression and metastasis.
Dexuan Zhuang +15 more
doaj +2 more sources
Cytotoxic effects of Phenformin on ovarian cancer cells: expression of HIF-1α and PDK1 in the hypoxic microenvironment. [PDF]
Rom J Morphol Embryol, 2023 Today, many anticancer drugs are used clinically for ovarian cancer, one of the leading causes of cancer-related deaths in women. Phenformin is an antidiabetic drug of the biguanide class.
Gunaydin B, Yigitturk G, Elbe H.
europepmc +2 more sources