Results 11 to 20 of about 6,115 (220)

Phenformin Inhibits Hedgehog-Dependent Tumor Growth through a Complex I-Independent Redox/Corepressor Module

Cell Reports, 2020
Summary: The antidiabetic drug phenformin displays potent anticancer activity in different tumors, but its mechanism of action remains elusive. Using Shh medulloblastoma as model, we show here that at clinically relevant concentrations, phenformin ...
Laura Di Magno, Simona Manni, Fiorella Di Pastena, Sonia Coni, Alberto Macone, Sara Cairoli, Manolo Sambucci, Paola Infante, Marta Moretti, Marialaura Petroni, Carmine Nicoletti, Carlo Capalbo, Enrico De Smaele, Lucia Di Marcotullio, Giuseppe Giannini, Luca Battistini, Bianca Maria Goffredo, Egidio Iorio, Enzo Agostinelli, Marella Maroder, Gianluca Canettieri   +20 more
doaj   +2 more sources

Phenformin attenuates the oxidative-nitrosative stress in the liver of rats under long-term ethanol administration [PDF]

The Ukrainian Biochemical Journal
Modulation of the AMP-activated protein kinase (AMPK) pathway activity is considered to be a promi­sing option in the development of approaches to chronic alcoholic hepatitis treatment. Phenformin, which is a biguanide, has been reported to increase AMPK
A. Mykytenko, O. Akimov, G. Yeroshenko, K. Neporada   +3 more
doaj   +2 more sources

Selectively down-regulated PD-L1 by albumin-phenformin nanoparticles mediated mitochondrial dysfunction to stimulate tumor-specific immunological response for enhanced mild-temperature photothermal efficacy

Journal of Nanobiotechnology, 2021
Highlights Over-expression of PD-L1 after mild-photothermal therapy significantly limited its efficacy. Phenformin could effectively downregulate PD-L1 expression and inhibit tumor metastasis through AMPK activation.
Zaigang Zhou, Ning Jiang, Jiashe Chen, Chunjuan Zheng, Yuanyuan Guo, Ruirong Ye, Ruogu Qi, Jianliang Shen   +7 more
doaj   +2 more sources

Phenformin and ataxia‐telangiectasia mutated inhibitors synergistically co‐suppress liver cancer cell growth by damaging mitochondria

FEBS Open Bio, 2021
Inhibitors of ataxia–telangiectasia mutated (ATM), such as KU‐55933 (Ku), represent a promising class of novel anticancer drugs. In addition, the biguanide derivative phenformin exhibits antitumor activity superior to that of the AMPK activator metformin.
Tianyu Wu, Sichun Zhou, Mei Qin, Jing Tang, Xinjian Yan, Lingli Huang, Meiyuan Huang, Jun Deng, Di Xiao, Xin Hu, Jingtao Wu, Xiaoping Yang, Gaofeng Li   +12 more
doaj   +2 more sources

Repurposing Metabolic Inhibitors in the Treatment of Colon Adenocarcinoma Patient-Derived Models [PDF]

Cells, 2023
The effect of agonists on AMP-activated protein kinase (AMPK), mainly metformin and phenformin, has been appreciated in the treatment of multiple types of tumors.
Bora Lee, ChuHee Lee, Hae-Min Moon, Se-Young Jo, Se Jin Jang, Young-Ah Suh   +5 more
doaj   +2 more sources

A Novel Electrochemical Biosensor based on Layered Hydroxide Nanosheets/DNA Composite for the Determination of Phenformin Hydrochloride

International Journal of Electrochemical Science, 2021
Layered double hydroxides (LDHs) are a kind of lamellar materials, which have been widely developed in electrochemical sensor owing to theirexcellent properties, such as large specific surface area, unique ion-exchange characteristic and good ...
Jing Li, Jie Bai, Li Dong, Miao Yang, Yaping Hu, Li Gao, Huiqin Qian   +6 more
doaj   +2 more sources

Enhanced Sensitivity of Nonsmall Cell Lung Cancer with Acquired Resistance to Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors to Phenformin: The Roles of a Metabolic Shift to Oxidative Phosphorylation and Redox Balance [PDF]

Oxidative Medicine and Cellular Longevity, 2021
Background Although the efficacy of epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR- TKI) therapy has been proven in non-small cell lung cancer (NSCLC) patients, acquired resistance to EGFR-TKIs presents a serious clinical problem. Hence,
Suntae Kim, J. Im, Wankyu Kim, Young Jae Choi, Ji-Yoon Lee, Sang Kyum Kim, Sun Jo Kim, S. Kwon, K. Kang   +8 more
semanticscholar   +2 more sources

A Comparative Study of the Lipophilicity of Metformin and Phenformin

Molecules, 2021
The results presented in this paper confirm the beneficial role of an easy-to-use and low-cost thin-layer chromatography (TLC) technique for describing the retention behavior and the experimental lipophilicity parameter of two biguanide derivatives ...
Małgorzata Dołowy, Josef Jampilek, Katarzyna Bober-Majnusz   +2 more
doaj   +2 more sources

STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer

Nature Communications, 2021
Complex I inhibition induces oxidative stress leading to cancer cell cytotoxicity. Here, the authors show, in breast cancer models, that inflammatory mediators can potentiate complex I inhibitor phenformin cytotoxicity through STAT1-mediated ...
Stephanie P. Totten, Young Kyuen Im, Eduardo Cepeda Cañedo, Ouafa Najyb, Alice Nguyen, Steven Hébert, Ryuhjin Ahn, Kyle Lewis, Benjamin Lebeau, Rachel La Selva, Valérie Sabourin, Constanza Martínez, Paul Savage, Hellen Kuasne, Daina Avizonis, Nancy Santos Martínez, Catherine Chabot, Adriana Aguilar-Mahecha, Marie-Line Goulet, Matthew Dankner, Michael Witcher, Kevin Petrecca, Mark Basik, Michael Pollak, Ivan Topisirovic, Rongtuan Lin, Peter M. Siegel, Claudia L. Kleinman, Morag Park, Julie St-Pierre, Josie Ursini-Siegel   +30 more
doaj   +2 more sources

Metabolic reprogramming in diffuse intrinsic pontine gliomas (DIPG): dual inhibition of mitochondrial oxidative phosphorylation and lactate metabolism to enhance anti-tumor and radiosensitizing effects in DIPG cells [PDF]

Cancer & Metabolism
Background Diffuse midline gliomas (DMGs), including diffuse intrinsic pontine gliomas (DIPGs), are universally fatal pediatric brain tumors with no effective treatments.
Han Shen, Quy-Susan Huynh, Faiqa Mudassar, Cecilia Chang, Brian Gloss, Prunella Ing, Shiyong Ma, Harriet Gee, Eric Hau, Kristina M. Cook   +9 more
doaj   +2 more sources