Results 21 to 30 of about 6,115 (220)
Synergistic anti-cancer effect of phenformin and oxamate. [PDF]
PLoS ONE, 2014 Phenformin (phenethylbiguanide; an anti-diabetic agent) plus oxamate [lactate dehydrogenase (LDH) inhibitor] was tested as a potential anti-cancer therapeutic combination. In in vitro studies, phenformin was more potent than metformin, another biguanide,
W Keith Miskimins +5 more
doaj +3 more sources
Biomolecules, 2020 Damage to cerebral mitochondria, particularly opening of mitochondrial permeability transition pore (MPTP), is a key mechanism of ischemic brain injury, therefore, modulation of MPTP may be a potential target for a neuroprotective strategy in ischemic ...
Kristina Skemiene +5 more
doaj +2 more sources
Pharmaceutics, 2020 Phenformin and metformin are antihyperglycemic drugs that belong to the class of biguanides. Previously, we demonstrated that metformin elicits renoprotective effects in unilateral ureteral obstructed mice by reducing the infiltration of immune cells ...
Mikkel Ø. Nørgård +3 more
doaj +2 more sources
Novel combination therapy with phenformin enhances the effects of lenvatinib in hepatocellular carcinoma via AMPK-mediated PDGFRβ degradation [PDF]
Cancer Cell InternationalBackground Hepatocellular carcinoma (HCC) is an invasive malignant tumour for which few effective treatment options are currently available. Lenvatinib is a small-molecule inhibitor of multiple receptor tyrosine kinases used for the treatment of patients
Duo Li +9 more
doaj +2 more sources
Crystal Growth & Design, 2023 : Here, we discuss crystal and solution/gas-phase complexes of carboxylated pillar[5]arene with two cationic guests, alexidine and phenformin, revealing host − guest and assembly curiosities, the role of hydrogen bonding, and cavity inclusion versus exo -
H. Butkiewicz +4 more
semanticscholar +2 more sources
Antifibrin action of phenformin [PDF]
Diabetologia, 1975 Effects of phenformin on blood sugar, serum triglyceride, thrombin time, euglobulin clot lysis time and cardiovascular complications were studied in maturity onset diabetes and in atherosclerotic patients with or without diabetes, for a period of 14-18 months.
R N, Banerjee +5 more
openaire +4 more sources
The Combination of Loss of ALDH1L1 Function and Phenformin Treatment Decreases Tumor Growth in KRAS-Driven Lung Cancer [PDF]
Cancers, 2020 Lung adenocarcinoma cells express high levels of ALDH1L1, an enzyme of the one-carbon pathway that catalyzes the conversion of 10-formyltetrahydrofolate into tetrahydrofolate and NAD(P)H.
Seon-Hyeong Lee +5 more
semanticscholar +2 more sources
Phenformin alone or combined with gefitinib inhibits bladder cancer via AMPK and EGFR pathways
Cancer Communications, 2018 Background In previous studies, we have shown that the combination of metformin and gefitinib inhibits the growth of bladder cancer cells. Here we examined whether the metformin analogue phenformin, either used alone or in combination with gefitinib ...
Yanjun Huang +8 more
doaj +2 more sources
Mechanisms of NMDA Receptor Inhibition by Biguanide Compounds [PDF]
PharmaceuticalsN-methyl-D-aspartate (NMDA) receptors are inhibited by many medicinal drugs. The recent successful repurposing of NMDA receptor antagonists ketamine and dextromethorphan for the treatment of major depressive disorder further enhanced the interest in this
Arseniy S. Zhigulin +2 more
doaj +2 more sources
Artificial Cells, Nanomedicine, and Biotechnology, 2019 Radiotherapy (RT) is a common treatment for head and neck cancers, but central nervous system function can be impaired by clinical radiation doses. This experimental study evaluated the protective efficacy of the anti-hyperglycaemic/anti-neoplastic agent
Lu Gan +9 more
doaj +2 more sources