Results 31 to 40 of about 6,115 (220)

AMP‐dependent kinase stimulates the expression of αKlotho [PDF]

FEBS Open Bio
Renal αKlotho along with fibroblast growth factor 23 regulates phosphate and vitamin D metabolism. Its cleavage yields soluble Klotho controlling intracellular processes.
Julia Vogt, Lisa Wolf, Ludwig E. Hoelzle, Martina Feger, Michael Föller   +4 more
doaj   +2 more sources

Combination of metformin and phenformin synergistically inhibits proliferation and hTERT expression in human breast cancer cells [PDF]

Iranian Journal of Basic Medical Sciences, 2018
Objective(s): Breast cancer remains a global challenge, and further chemopreventive therapies are still immediately required. Emerging evidence has revealed the potent anti-cancer effects of biguanides, Metformin (MET) and phenformin (PHE).
Davoud Jafari-Gharabaghlou, Younes Pilehvar-Soltanahmadi, Mehdi Dadashpour, Ali Mota, Soheila Vafajouy-Jamshidi, Leila Faramarzi, Sara Rasouli, Nosratollah Zarghami   +7 more
doaj   +2 more sources

ZnO/Ag nanorods as a prominent SERS substrate contributed by synergistic charge transfer effect for simultaneous detection of oral antidiabetic drugs pioglitazone and phenformin

, 2020
Chunyan Liu, Xiaohui Xu, Changding Wang, Guoyu Qiu, Weichun Ye, Yumin Li, Degui Wang   +6 more
semanticscholar   +3 more sources

m6A-Mediated Methylation Patterns and Their Association With Obstructive Sleep Apnea in Lung Adenocarcinoma. [PDF]

Cancer Rep (Hoboken)
ABSTRACT Background Epigenetic regulation significantly affects immune responses in lung adenocarcinoma (LUAD). However, the role of RNA N6‐methyladenosine (m6A) modification, especially in obstructive sleep apnea‐hypopnea syndrome (OSAHS) within LUAD, is not well understood.
Xia L, Chai Z, Wei X, Wei Y, Zeng D, Jiang J, Li J.   +6 more
europepmc   +2 more sources

Treatment of Pancreatic Cancer Patient–Derived Xenograft Panel with Metabolic Inhibitors Reveals Efficacy of Phenformin [PDF]

Clinical Cancer Research, 2017
N. Rajeshkumar, S. Yabuuchi, Shweta Pai, E. de Oliveira, Jurre J. Kamphorst, J. Rabinowitz, Héctor Tejero, F. Al-Shahrour, M. Hidalgo, A. Maitra, C. Dang   +10 more
semanticscholar   +2 more sources

Metformin, phenformin, and galegine inhibit complex IV activity and reduce glycerol-derived gluconeogenesis

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance Metformin is the most commonly prescribed drug for the treatment of type 2 diabetes mellitus, yet the mechanism by which it lowers plasma glucose concentrations has remained elusive.
Traci E LaMoia, G. Butrico, Hasini A. Kalpage, L. Goedeke, Brandon T. Hubbard, D. Vatner, R. C. Gaspar, Xian-Man Zhang, G. Cline, Keita Nakahara, Seungwan Woo, A. Shimada, M. Hüttemann, G. Shulman   +13 more
semanticscholar   +1 more source

Phenformin Induces Cell Cycle Change, Apoptosis, and Mesenchymal-Epithelial Transition and Regulates the AMPK/mTOR/p70s6k and MAPK/ERK Pathways in Breast Cancer Cells. [PDF]

PLoS ONE, 2015
Breast cancer remains a world-wide challenge, and additional anti-cancer therapies are still urgently needed. Emerging evidence has demonstrated the potent anti-tumor effect of biguanides, among which phenformin was reported to potentially be a more ...
Zhao Liu, Lidong Ren, Chenghao Liu, Tiansong Xia, Xiaoming Zha, Shui Wang   +5 more
doaj   +1 more source

Metformin Downregulates the STAT Pathway and Reduces Bone Marrow Fibrosis in Primary Myelofibrosis Patients: Final Results of the Phase II FIBROMET Trial. [PDF]

Hematol Oncol
ABSTRACT Primary myelofibrosis (PMF) is a chronic myeloproliferative neoplasm characterized by the activation of the JAK‐STAT pathway. Previous evidence showed that metformin might be a possible therapeutic option for treating JAK2‐mediated myeloproliferative neoplasms.
Melo Campos P, Pagnano KBB, Niemann FS, Mancuso RI, Della Via FI, Congrains A, Coelho-Silva JL, Tinoco ÂC, Assis-Mendonça GR, Freitas LLL, Traina F, Saad STO.   +11 more
europepmc   +2 more sources

Graphene-based phenformin carriers for cancer cell treatment: a comparative study between oxidized and pegylated pristine graphene in human cells and zebrafish

Nanoscale Advances, 2022
Graphene is an attractive choice for the development of an effective drug carrier in cancer treatment due to its high adsorption area and pH-responsive drug affinity.
A. Alhourani, Jan-Lukas Førde, Mojdeh Nasrollahzadeh, L. Eichacker, L. Herfindal, H. Hagland   +5 more
semanticscholar   +1 more source

A novel biguanide derivative, IM176, induces prostate cancer cell death by modulating the AMPK-mTOR and androgen receptor signaling pathways

Prostate International, 2023
Background: Metformin and phenformin, biguanide derivatives that are widely used to treat type 2 diabetes mellitus, have recently been shown to exert potential anticancer effects in prostate cancer.
Yunlim Kim, Sangjun Yoo, Bumjin Lim, Jun Hyuk Hong, Cheol Kwak, Dalsan You, Jung Jin Hwang, Choung-Soo Kim   +7 more
doaj   +1 more source