Results 71 to 80 of about 6,115 (220)

Therapeutic Potential of Lavandula stoechas Aqueous Extract in Managing Diabetes and Its Complications: Insights From Biochemical and In Silico Studies

Food Science &Nutrition, Volume 13, Issue 6, June 2025.
The aqueous extract of Lavandula stoechas (AqLs) significantly reduced blood glucose and improved lipid profiles in alloxan‐induced diabetic rats. It also enhanced liver glycogen and protected against liver and kidney dysfunction. In silico analysis of key phytochemicals supported their pharmacokinetic potential and safety, highlighting L.
Amal Elrherabi, Fahd A. Nasr, Ayoub Farihi, Mohamed Bouhrim, El Hassania Loukili, Mounia Driouech, Nour elhouda Daoudi, Mohammed Al‐zharani, Ashraf Ahmed Qurtam, Mohamed Bnouham   +9 more
wiley   +1 more source

Multiomics‐Driven Drug‐Cell Interaction Network for Chemotherapy Sensitivity Prediction in Metabolically Defined Triple‐Negative Breast Cancer Subtypes

Journal of Cellular and Molecular Medicine, Volume 29, Issue 11, June 2025.
ABSTRACT Triple‐negative breast cancer (TNBC) is associated with a poor prognosis due to insufficient molecular subtyping precision and limited actionable targets. Although metabolic reprogramming underlies TNBC chemotherapy resistance, establishing metabolic subtyping systems and investigating drug sensitivity across distinct metabolic subgroups could
Jingyuan Zhang, Xuejun Sun
wiley   +1 more source

Inhibition of Endoplasmic Reticulum Stress Cooperates with SLC7A11 to Promote Disulfidptosis and Suppress Tumor Growth upon Glucose Limitation

Advanced Science, Volume 12, Issue 7, February 17, 2025.
Disulfidptosis is a recently identified form of cell death with largely unknown regulatory mechanisms. It is found that SLC7A11‐mediated disulfidptosis in the absence of glucose promotes an ER stress response involving the eIF2α/ATF4 pathway. Inhibition of ER stress enhances tumor suppression by accelerating disulfidptosis induced by GLUT inhibitors ...
Jin Wang, Jing Chen, Kexin Fan, Minglin Wang, Min Gao, Yakun Ren, Shaobo Wu, Qian He, Kangsheng Tu, Qiuran Xu, Yilei Zhang   +10 more
wiley   +1 more source

Metabolic Rewiring in Response to Biguanides Is Mediated by mROS/HIF-1a in Malignant Lymphocytes

Cell Reports, 2019
Summary: Metabolic flexibility allows cells to adapt to various environments and limits the efficacy of metabolic drugs. Therapeutic targeting of cancer metabolism relies on defining limiting requirements and vulnerabilities in the highly dynamic ...
Hamidullah Khan, Ashish Anshu, Aman Prasad, Sushmita Roy, Justin Jeffery, Wasakorn Kittipongdaja, David T. Yang, Stefan M. Schieke   +7 more
doaj   +1 more source

Boosting disassembly of π–π stacked supramolecular nanodrugs under tumor microenvironment by introducing stimuli‐responsive drug‐mates

Aggregate, Volume 6, Issue 1, January 2025.
A concept of stimuli‐responsive drug‐mates is proposed for boosting the disassembly of π–π stacked supramolecular nanodrugs under tumor microenvironment (TME), in which π‐conjugated drugs are foremost co‐assembled with additional drug molecules that possess relatively weak π–π interaction but high TME responsiveness.
Wenzhe Xu, Ruixu Yang, Yingke Xue, Yang Chen, Shuwei Liu, Songling Zhang, Yonggang Wang, Yi Liu, Hao Zhang   +8 more
wiley   +1 more source

Metformin selectively targets redox control of complex I energy transduction

Redox Biology, 2018
Many guanide-containing drugs are antihyperglycaemic but most exhibit toxicity, to the extent that only the biguanide metformin has enjoyed sustained clinical use. Here, we have isolated unique mitochondrial redox control properties of metformin that are
Amy R. Cameron, Lisa Logie, Kashyap Patel, Stefan Erhardt, Sandra Bacon, Paul Middleton, Jean Harthill, Calum Forteath, Josh T. Coats, Calum Kerr, Heather Curry, Derek Stewart, Kei Sakamoto, Peter Repiščák, Martin J. Paterson, Ilmo Hassinen, Gordon McDougall, Graham Rena   +17 more
doaj   +1 more source

Supplementary Figure 3 from Phase Ib Trial of Phenformin in Patients with V600-mutated Melanoma Receiving Dabrafenib and Trametinib [PDF]

, 2023
Paul B. Chapman, Mark Klang, Michael A. Postow, Alexander N. Shoushtari, Ryan J. Sullivan, Jedd D. Wolchok, Taha Merghoub, Sadna Budhu, Phillip Wong, Margaret K. Callahan, Bin Zheng, Jonathan H. Zippin   +11 more
openalex   +1 more source

Exploring New Frontiers: Alternative Breast Cancer Treatments Through Glycocalyx Research

The Breast Journal, Volume 2025, Issue 1, 2025.
Breast cancer (BC) treatment is developing toward more precise and personalized care through the approval of different comprehensive approaches. Clinical practice emphasizes significant patient‐to‐patient variability in treatment response among patients, even those with similar clinical and biological profiles. Recent studies have demonstrated that the
Ielizaveta Gorodetska, Anastasiia Samusieva, Tetiana Lahuta, Olga Ponomarova, Oleg Socha, Iryna Kozeretska, Karuna Sharma   +6 more
wiley   +1 more source

Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade

Journal of Biology, 2003
Background The AMP-activated protein kinase (AMPK) cascade is a sensor of cellular energy charge that acts as a 'metabolic master switch' and inhibits cell proliferation. Activation requires phosphorylation of Thr172 of AMPK within the activation loop by
Alessi Dario R, Mäkelä Tomi P, Mustard Kirsty J, Udd Lina, Reid Jennifer L, Boudeau Jérôme, Hawley Simon A, Hardie D Grahame   +7 more
doaj   +1 more source

FIGURE 3 from Phase Ib Trial of Phenformin in Patients with V600-mutated Melanoma Receiving Dabrafenib and Trametinib

, 2023
Paul B. Chapman, Mark Klang, Michael A. Postow, Alexander N. Shoushtari, Ryan J. Sullivan, Jedd D. Wolchok, Taha Merghoub, Sadna Budhu, Phillip Wong, Margaret K. Callahan, Bin Zheng, Jonathan H. Zippin   +11 more
openalex   +2 more sources