Results 81 to 90 of about 6,115 (220)

The anti-cancer effects of phenformin in thyroid cancer cell lines and in normal thyrocytes

OncoTarget, 2019
Phenformin is a biguanide drug which, besides the original anti-diabetic effect, also exerts anti-cancer effects. The aim of this study was to further characterize these latter in terms of both cell-viability and modulation of the secretion of the pro ...
F. Coperchini, L. Croce, M. Denegri, O. Awwad, S. T. Ngnitejeu, F. Magri, L. Chiovato, M. Rotondi   +7 more
semanticscholar   +1 more source

Inhibition of Chloride Intracellular Channel 1 (CLIC1) as Biguanide Class-Effect to Impair Human Glioblastoma Stem Cell Viability

Frontiers in Pharmacology, 2018
The antidiabetic biguanide metformin exerts antiproliferative effects in different solid tumors. However, during preclinical studies, metformin concentrations required to induce cell growth arrest were invariably within the mM range, thus difficult to ...
Federica Barbieri, Roberto Würth, Alessandra Pattarozzi, Ivan Verduci, Chiara Mazzola, Maria G. Cattaneo, Michele Tonelli, Agnese Solari, Adriana Bajetto, Antonio Daga, Lucia M. Vicentini, Michele Mazzanti, Tullio Florio, Tullio Florio   +13 more
doaj   +1 more source

Imeglimin and DPP‐4 inhibitors: A promising therapeutic strategy for type 2 diabetes individuals with reduced insulin secretion

Diabetes, Obesity and Metabolism, Volume 27, Issue 7, Page 4034-4036, July 2025.
Yoshiyuki Hamamoto, Ryota Usui
wiley   +1 more source

Targeting Tumor Mitochondrial Metabolism Overcomes Resistance to Antiangiogenics

Cell Reports, 2016
Epithelial malignancies are effectively treated by antiangiogenics; however, acquired resistance is a major problem in cancer therapeutics. Epithelial tumors commonly have mutations in the MAPK/Pi3K-AKT pathways, which leads to high-rate aerobic ...
Paloma Navarro, Maria J. Bueno, Ivana Zagorac, Tamara Mondejar, Jesus Sanchez, Silvana Mourón, Javier Muñoz, Gonzalo Gómez-López, Veronica Jimenez-Renard, Francisca Mulero, Navdeep S. Chandel, Miguel Quintela-Fandino   +11 more
doaj   +1 more source

IKK promotes cytokine-induced and cancer-associated AMPK activity and attenuates phenformin-induced cell death in LKB1-deficient cells

Science Signaling, 2018
AMPK activity is stimulated by IKK-mediated phosphorylation in cancer cells and downstream of inflammatory cytokines. An inflammatory way to activate AMPK In its best-known function as a sensor of energy status, the kinase AMPK is activated by ...
Ricardo J. Antonia, A. Baldwin
semanticscholar   +1 more source

IKK promotes cytokine-induced and cancer-associated AMPK activity and attenuates phenformin-induced cell death in LKB1-deficient cells

, 2022
R.J. Antonia, A.S. Baldwin
openalex   +1 more source

Phenformin and metformin inhibit growth and migration of LN229 glioma cells in vitro and in vivo

OncoTargets and Therapy, 2018
Background Malignant glioma is refractory to conventional treatment, highlighting a need to develop novel efficacious therapies. Biguanides, a class of oral antidiabetic drug, have been thought to inhibit proliferation and metastasis in a variety of ...
Yanmin Wang, Yanli Meng, Shijun Zhang, Huancheng Wu, Dawei Yang, Chaohui Nie, Qunliang Hu   +6 more
semanticscholar   +1 more source

Supplementary Figure S1 from Effects of Metformin, Buformin, and Phenformin on the Post-Initiation Stage of Chemically Induced Mammary Carcinogenesis in the Rat

, 2023
Zongjian Zhu, Weiqin Jiang, Matthew D. Thompson, Dimas Echeverria, John N. McGinley, Henry J. Thompson   +5 more
openalex   +1 more source

lncRNA NBR2 modulates cancer cell sensitivity to phenformin through GLUT1 [PDF]

, 2016
Xiaowen Liu, Boyi Gan
openalex   +1 more source

Phenformin and pulmonary hypertension. [PDF]

, 1973
Mark Fahlen, Halvar Bergman, G Helder, Lina Rydén, I Wallentin, L Zettergren   +5 more
openalex   +1 more source