Efficacy of phenobarbital is maintained after exposure to mild‐to‐moderate seizures in neonates [PDF]
Epilepsia OpenTo study the relationship between the delay in treatment and the efficacy of phenobarbital in neonates, we re‐analyzed data from the NEOLEV2 study. Continuous video EEG (cEEG) from patients treated with phenobarbital was reviewed by neurophysiologists ...
Cynthia Sharpe +9 more
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Frontiers in Neurology, 2019 Introduction: Pediatric convulsive status epilepticus (CSE) which is refractory to first-line benzodiazepines is a significant clinical challenge, especially within resource-limited countries.
Richard J. Burman +8 more
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MicroRNA-122 down-regulation is involved in phenobarbital-mediated activation of the constitutive androstane receptor. [PDF]
PLoS ONE, 2012 Constitutive androstane receptor (CAR) is a nuclear receptor that regulates the transcription of target genes, including CYP2B and 3A. Phenobarbital activates CAR, at least in part, in an AMP-activated protein kinase (AMPK)-dependent manner. However, the
Ryota Shizu +3 more
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Phenobarbital versus morphine in the management of neonatal abstinence syndrome, a randomized control trial [PDF]
BMC Pediatrics, 2015 BackgroundsEvaluating the efficacy of the loading and tapering dose of Phenobarbital versus oral Morphine in the management of NAS.MethodsThis randomized, open-label, controlled trial was conducted on 60 neonates born to illicit drugs dependent mothers ...
Fatemeh Nayeri +6 more
openalex +2 more sources
Effects of Phenobarbital and Prednisolone on Neurological Signs of Canine Distemper. [PDF]
Vet Med SciSarchahi AA, Arbabi M, Mohebalian H.
europepmc +3 more sources
Phenobarbital versus benzodiazepines in alcohol withdrawal syndrome
Neuropsychopharmacology Reports, 2023 Aim Phenobarbital, a long‐acting barbiturate, presents an alternative to conventional benzodiazepine treatment for alcohol withdrawal syndrome (AWS).
Deanna Malone +5 more
doaj +1 more source
Evaluation of Prophylactic and Therapeutic Effects of Silymarin on Phenobar- bital-Induced Hepatotoxicity in Cats [PDF]
Iranian Journal of Veterinary Medicine, 2020 BACKGROUND: Phenobarbital is one of the most commonly used drugs to treat epilepsy and other seizure disorders in dogs and cats. Hepatotoxicity following phenobarbital administration is dose-dependent.
Bahman Mosallanejad +3 more
doaj +1 more source
Levetiracetam Versus Phenobarbital for Neonatal Seizures: A Randomized Controlled Trial
Pediatrics, 2020 This phase IIb randomized controlled trial demonstrates greater efficacy of phenobarbital than levetiracetam in the treatment of neonatal seizures; more adverse events occurred with phenobarbital.
Cynthia Sharpe +24 more
semanticscholar +1 more source
Pharmacokinetics of Intravenous and Oral Phenobarbital Sodium in Healthy Goats
Frontiers in Veterinary Science, 2020 Phenobarbital is a common drug used to manage epilepsy in goats. However, the recommended dose and dosing frequency are based on studies in dogs and horses.
Liana M. Yates +5 more
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