Exposure to excess phenobarbital negatively influences the osteogenesis of chick embryos [PDF]
Frontiers in Pharmacology, 2016 Phenobarbital is an antiepileptic drug that is widely used to treat epilepsy in a clinical setting. However, a long term of phenobarbital administration in pregnant women may produce side effects on embryonic skeletogenesis.
Yu Yan +8 more
doaj +5 more sources
Comparison between the Amount of Environmental Change and the Amount of Transcriptome Change. [PDF]
PLoS ONE, 2015 Cells must coordinate adjustments in genome expression to accommodate changes in their environment. We hypothesized that the amount of transcriptome change is proportional to the amount of environmental change.
Norichika Ogata +4 more
doaj +2 more sources
Pharmacokinetic analysis of a phenobarbital overdose treated with urinary alkalinization alone [PDF]
Toxicology ReportsPhenobarbital is a long-acting barbiturate used to treat alcohol withdrawal and epilepsy. Acute overdoses present with varying levels of central nervous system depression and large overdoses can be life threatening.
Justin Seltzer +5 more
doaj +2 more sources
Phenobarbital versus benzodiazepines in alcohol withdrawal syndrome
Neuropsychopharmacology Reports, 2023 Aim Phenobarbital, a long‐acting barbiturate, presents an alternative to conventional benzodiazepine treatment for alcohol withdrawal syndrome (AWS).
Deanna Malone +5 more
doaj +1 more source
Evaluation of Prophylactic and Therapeutic Effects of Silymarin on Phenobar- bital-Induced Hepatotoxicity in Cats [PDF]
Iranian Journal of Veterinary Medicine, 2020 BACKGROUND: Phenobarbital is one of the most commonly used drugs to treat epilepsy and other seizure disorders in dogs and cats. Hepatotoxicity following phenobarbital administration is dose-dependent.
Bahman Mosallanejad +3 more
doaj +1 more source
Pharmacokinetics of Intravenous and Oral Phenobarbital Sodium in Healthy Goats
Frontiers in Veterinary Science, 2020 Phenobarbital is a common drug used to manage epilepsy in goats. However, the recommended dose and dosing frequency are based on studies in dogs and horses.
Liana M. Yates +5 more
doaj +1 more source
The roles of co-chaperone CCRP/DNAJC7 in Cyp2b10 gene activation and steatosis development in mouse livers. [PDF]
PLoS ONE, 2014 Cytoplasmic constitutive active/androstane receptor (CAR) retention protein (CCRP and also known as DNAJC7) is a co-chaperone previously characterized to retain nuclear receptor CAR in the cytoplasm of HepG2 cells. Here we have produced CCRP knockout (KO)
Marumi Ohno +4 more
doaj +1 more source
Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2022 Hepatocellular proliferation is one of the most common causes of hepatocellular carcinoma (HCC), a type of cancer that is widely distributed disease. Hepatocellular carcinoma treatment has numerous barriers, including ineffectiveness, side effects, and ...
Ibtehal Naseer Salman +2 more
doaj +1 more source
Suspected phenobarbital-induced pancytopenia in a cat
Journal of Feline Medicine and Surgery Open Reports, 2020 Case summary A 3-year-old neutered male domestic shorthair cat developed pancytopenia 6 months after starting phenobarbital for treatment of recurrent seizures.
Maria Lyraki, Helen Wilson
doaj +1 more source
Oral Loading of Phenobarbital to Achieve Therapeutic Effects in Pediatric Patients with Acute Repetitive Seizures [PDF]
Annals of Child Neurology, 2023 Purpose Intravenous phenobarbital has not been available at our institution since 2019. This study aimed to determine the effectiveness of oral phenobarbital loading at a dose of 15 to 20 mg/kg to achieve therapeutic serum levels and clinical seizure ...
Jemima Grace D. Fronda +2 more
doaj +1 more source