Safety and effectiveness of phenobarbital vs. benzodiazepines for severe alcohol withdrawal in alcohol-associated liver disease in the ICU [PDF]
JHEP ReportsBackground & Aims: Severe alcohol withdrawal syndrome (SAWS) in patients with alcohol-associated liver disease (ALD) presents management challenges due to altered drug metabolism and increased toxicity.
Rajalakshmi Govalan +4 more
doaj +2 more sources
Antiseizure monotherapy with imepitoin or phenobarbital in feline idiopathic epilepsy: a multicenter, single-blinded, randomized and placebo-controlled study [PDF]
Frontiers in Veterinary ScienceIn feline idiopathic epilepsy (IE), the options for antiseizure medications (ASMs) remain limited with no licensed drugs available in cats in Europe. This study aimed to evaluate and compare efficacy and safety of imepitoin and phenobarbital through a ...
Marios Charalambous +8 more
doaj +2 more sources
Phenobarbital versus benzodiazepines in alcohol withdrawal syndrome
Neuropsychopharmacology Reports, 2023 Aim Phenobarbital, a long‐acting barbiturate, presents an alternative to conventional benzodiazepine treatment for alcohol withdrawal syndrome (AWS).
Deanna Malone +5 more
doaj +1 more source
Evaluation of Prophylactic and Therapeutic Effects of Silymarin on Phenobar- bital-Induced Hepatotoxicity in Cats [PDF]
Iranian Journal of Veterinary Medicine, 2020 BACKGROUND: Phenobarbital is one of the most commonly used drugs to treat epilepsy and other seizure disorders in dogs and cats. Hepatotoxicity following phenobarbital administration is dose-dependent.
Bahman Mosallanejad +3 more
doaj +1 more source
Pharmacokinetics of Intravenous and Oral Phenobarbital Sodium in Healthy Goats
Frontiers in Veterinary Science, 2020 Phenobarbital is a common drug used to manage epilepsy in goats. However, the recommended dose and dosing frequency are based on studies in dogs and horses.
Liana M. Yates +5 more
doaj +1 more source
The roles of co-chaperone CCRP/DNAJC7 in Cyp2b10 gene activation and steatosis development in mouse livers. [PDF]
PLoS ONE, 2014 Cytoplasmic constitutive active/androstane receptor (CAR) retention protein (CCRP and also known as DNAJC7) is a co-chaperone previously characterized to retain nuclear receptor CAR in the cytoplasm of HepG2 cells. Here we have produced CCRP knockout (KO)
Marumi Ohno +4 more
doaj +1 more source
Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2022 Hepatocellular proliferation is one of the most common causes of hepatocellular carcinoma (HCC), a type of cancer that is widely distributed disease. Hepatocellular carcinoma treatment has numerous barriers, including ineffectiveness, side effects, and ...
Ibtehal Naseer Salman +2 more
doaj +1 more source
Suspected phenobarbital-induced pancytopenia in a cat
Journal of Feline Medicine and Surgery Open Reports, 2020 Case summary A 3-year-old neutered male domestic shorthair cat developed pancytopenia 6 months after starting phenobarbital for treatment of recurrent seizures.
Maria Lyraki, Helen Wilson
doaj +1 more source
The Evidence Behind the Treatment of Canine Idiopathic Epilepsy [PDF]
, 2016 Oral phenobarbital and imepitoin in particular, followed by potassium bromide and levetiracetam are likely to be effective for the treatment of canine idiopathic epilepsy. There is strong evidence supporting the use of oral phenobarbital and imepitoin as
Brodbelt, D C +2 more
core +3 more sources
Exposure to excess phenobarbital negatively influences the osteogenesis of chick embryos
Frontiers in Pharmacology, 2016 Phenobarbital is an antiepileptic drug that is widely used to treat epilepsy in a clinical setting. However, a long term of phenobarbital administration in pregnant women may produce side effects on embryonic skeletogenesis.
Yu Yan +8 more
doaj +1 more source