Pharmacokinetic analysis of a phenobarbital overdose treated with urinary alkalinization alone [PDF]
Toxicology ReportsPhenobarbital is a long-acting barbiturate used to treat alcohol withdrawal and epilepsy. Acute overdoses present with varying levels of central nervous system depression and large overdoses can be life threatening.
Justin Seltzer +5 more
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Exposure to excess phenobarbital negatively influences the osteogenesis of chick embryos [PDF]
Frontiers in Pharmacology, 2016 Phenobarbital is an antiepileptic drug that is widely used to treat epilepsy in a clinical setting. However, a long term of phenobarbital administration in pregnant women may produce side effects on embryonic skeletogenesis.
Yu Yan +8 more
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Comparison between the Amount of Environmental Change and the Amount of Transcriptome Change. [PDF]
PLoS ONE, 2015 Cells must coordinate adjustments in genome expression to accommodate changes in their environment. We hypothesized that the amount of transcriptome change is proportional to the amount of environmental change.
Norichika Ogata +4 more
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Phenobarbital, Midazolam Pharmacokinetics, Effectiveness, and Drug-Drug Interaction in Asphyxiated Neonates Undergoing Therapeutic Hypothermia [PDF]
Neonatology, 2019 Background: Phenobarbital and midazolam are commonly used drugs in (near-)term neonates treated with therapeutic hypothermia for hypoxic-ischaemic encephalopathy, for sedation, and/or as anti-epileptic drug. Phenobarbital is an inducer of cytochrome P450
Laurent M A Favié +18 more
semanticscholar +3 more sources
Epilepsia Open, 2020 Objective Organophosphates (OPs) such as diisopropylfluorophosphate (DFP) and soman are lethal chemical agents that can produce seizures, refractory status epilepticus (SE), and brain damage.
Doodipala Samba Reddy +5 more
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Frontiers in Neurology, 2019 Introduction: Pediatric convulsive status epilepticus (CSE) which is refractory to first-line benzodiazepines is a significant clinical challenge, especially within resource-limited countries.
Richard J. Burman +8 more
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Toxic epidermal necrolysis caused by phenobarbital: a case report and literature review [PDF]
Frontiers in PharmacologyBackgroundToxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are rare, life-threatening immunologic reactions. Previous relevant literature has provided limited information regarding this disease’s genetic susceptibility and management ...
Jie Cheng +7 more
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Phenobarbital: missing in action.
Bulletin of the World Health Organization, 2012 Epilepsy affects more than 60 million people worldwide, and over 80% of them live in resource-poor countries.1 Approximately 85% of these people do not receive appropriate treatment2 because of economic, cultural, social and legislative barriers ...
Neshan B Ilangaratne +3 more
semanticscholar +4 more sources
MicroRNA-122 down-regulation is involved in phenobarbital-mediated activation of the constitutive androstane receptor. [PDF]
PLoS ONE, 2012 Constitutive androstane receptor (CAR) is a nuclear receptor that regulates the transcription of target genes, including CYP2B and 3A. Phenobarbital activates CAR, at least in part, in an AMP-activated protein kinase (AMPK)-dependent manner. However, the
Ryota Shizu +3 more
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Bumetanide enhances phenobarbital efficacy in a rat model of hypoxic neonatal seizures. [PDF]
PLoS ONE, 2013 Neonatal seizures can be refractory to conventional anticonvulsants, and this may in part be due to a developmental increase in expression of the neuronal Na(+)-K(+)-2 Cl(-) cotransporter, NKCC1, and consequent paradoxical excitatory actions of GABAA ...
Ryan T Cleary +11 more
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