Phenobarbital versus benzodiazepines in alcohol withdrawal syndrome
Neuropsychopharmacology Reports, 2023 Aim Phenobarbital, a longâacting barbiturate, presents an alternative to conventional benzodiazepine treatment for alcohol withdrawal syndrome (AWS).
Deanna Malone, Blair Costin
exaly +3 more sources
Phenobarbital Pharmacokinetics and Optimal Dosing of Phenobarbital
Pediatric Neurology Briefs, 2018 Researchers from the Baylor College of Medicine in Houston, TX, USA, conducted a retrospective population pharmacokinetic analysis of 355 patients ages less than 19 years of age in the inpatient setting who were initiated on intravenous or oral ...
Safiullah Shareef, Murtaza Nasir Ali
doaj +4 more sources
Pharmacokinetics of Intravenous and Oral Phenobarbital Sodium in Healthy Goats [PDF]
Frontiers in Veterinary Science, 2020 Phenobarbital is a common drug used to manage epilepsy in goats. However, the recommended dose and dosing frequency are based on studies in dogs and horses.
Liana M. Yates +5 more
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Real-World Phenobarbital Use, Treatment Escalation, and Clinical Outcomes in Critically Ill Patients With Alcohol Withdrawal Syndrome: A Multicenter Propensity-Matched Cohort Study [PDF]
Critical Care ExplorationsIMPORTANCE:. Phenobarbital use in ICU alcohol withdrawal syndrome (AWS) may reflect severe or refractory withdrawal and treatment escalation, making multicenter data important to understand its use within ICU practice and its relationship with clinical ...
Zeeshan M. Rizwan, PharmD, MPH +8 more
doaj +2 more sources
Safety and effectiveness of phenobarbital vs. benzodiazepines for severe alcohol withdrawal in alcohol-associated liver disease in the ICU [PDF]
JHEP ReportsBackground & Aims: Severe alcohol withdrawal syndrome (SAWS) in patients with alcohol-associated liver disease (ALD) presents management challenges due to altered drug metabolism and increased toxicity.
Rajalakshmi Govalan +4 more
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Evaluation of Prophylactic and Therapeutic Effects of Silymarin on Phenobar- bital-Induced Hepatotoxicity in Cats [PDF]
Iranian Journal of Veterinary Medicine, 2020 BACKGROUND: Phenobarbital is one of the most commonly used drugs to treat epilepsy and other seizure disorders in dogs and cats. Hepatotoxicity following phenobarbital administration is dose-dependent.
Bahman Mosallanejad +3 more
doaj +1 more source
The roles of co-chaperone CCRP/DNAJC7 in Cyp2b10 gene activation and steatosis development in mouse livers. [PDF]
PLoS ONE, 2014 Cytoplasmic constitutive active/androstane receptor (CAR) retention protein (CCRP and also known as DNAJC7) is a co-chaperone previously characterized to retain nuclear receptor CAR in the cytoplasm of HepG2 cells. Here we have produced CCRP knockout (KO)
Marumi Ohno +4 more
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Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2022 Hepatocellular proliferation is one of the most common causes of hepatocellular carcinoma (HCC), a type of cancer that is widely distributed disease. Hepatocellular carcinoma treatment has numerous barriers, including ineffectiveness, side effects, and ...
Ibtehal Naseer Salman +2 more
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Exposure to excess phenobarbital negatively influences the osteogenesis of chick embryos
Frontiers in Pharmacology, 2016 Phenobarbital is an antiepileptic drug that is widely used to treat epilepsy in a clinical setting. However, a long term of phenobarbital administration in pregnant women may produce side effects on embryonic skeletogenesis.
Yu Yan +8 more
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Suspected phenobarbital-induced pancytopenia in a cat
Journal of Feline Medicine and Surgery Open Reports, 2020 Case summary A 3-year-old neutered male domestic shorthair cat developed pancytopenia 6 months after starting phenobarbital for treatment of recurrent seizures.
Maria Lyraki, Helen Wilson
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