Results 71 to 80 of about 60,607 (241)

A Comparison of Parenteral Phenobarbital vs. Parenteral Phenytoin as Second-Line Management for Pediatric Convulsive Status Epilepticus in a Resource-Limited Setting

Frontiers in Neurology, 2019
Introduction: Pediatric convulsive status epilepticus (CSE) which is refractory to first-line benzodiazepines is a significant clinical challenge, especially within resource-limited countries.
Richard J. Burman, Richard J. Burman, Sally Ackermann, Alexander Shapson-Coe, Alvin Ndondo, Alvin Ndondo, Heloise Buys, Jo M. Wilmshurst, Jo M. Wilmshurst   +8 more
doaj   +1 more source

Effect of oxidative stress on ABC transporters: contribution to epilepsy pharmacoresistance [PDF]

, 2017
Epilepsy is a neurological disorder affecting around 1%-2% of population worldwide and its treatment includes use of antiepileptic drugs to control seizures. Failure to respond to antiepileptic drug therapy is a major clinical problem and over expression
Grewal, G. K., Kanojia, N., Kukal, S., Kukreti, R., Kukreti, S., Saso, L.   +5 more
core   +2 more sources

Investigation of cross-reactivity between phenobarbital and levetiracetam in children with epilepsy: A prospective, observational multicenter study

Epilepsy & Behavior Reports, 2023
Objectives: Pharmaceutical allergic reactions due to antiseizure medications (ASMs) are one of the major concerns in the management of patients. Finding an alternative ASM which does not cause allergic reactions and has acceptable effectiveness can be ...
Samane Rahimi, Bardia Danaei, Mohammad Mehdi Nasehi, Sasan Saket, Nazanin Farahbakhsh, Maryam Rajabnejad, Mohammad Mehdi Taghdiri   +6 more
doaj  

Prophylactic Phenobarbital after Resolution of Neonatal Seizures

Pediatric Neurology Briefs, 2008
The degree of practice variation in continuance of phenobarbital treatment despite resolution of neonatal seizures was evaluated by national survey conducted at the University of Rochester Medical Center, New York.
J Gordon Millichap
doaj   +1 more source

Effect of phenobarbital on nitric oxide level in term newborn infants with perinatal asphyxia [PDF]

, 2016
Perinatal asphyxia (PA) is very significant in perinatal medicine due to the involvement of the central nervous system. This study was conducted to investigate the biochemical, clinical, and paraclinical changes associated with phenobarbital ...
Heidarian, Esfandiar., Kheiri, Soleiman., Khoshdel, Abolfazl., Noormohammadi, Hajar., Nourbakhsh, Seyyed Mohammad-Kazem., Panahandeh, Gholamreza., Reisi, Roya.   +6 more
core   +2 more sources

City-wide Analysis of Electronic Health Records Reveals Gender and Age Biases in the Administration of Known Drug-Drug Interactions

, 2020
The occurrence of drug-drug-interactions (DDI) from multiple drug dispensations is a serious problem, both for individuals and health-care systems, since patients with complications due to DDI are likely to reenter the system at a costlier level.
Correia, Rion Brattig, de Araújo, Luciana P., Mattos, Mauro M., Rocha, Luis M.   +3 more
core   +1 more source

Pharmacokinetic analysis of a phenobarbital overdose treated with urinary alkalinization alone

Toxicology Reports
Phenobarbital is a long-acting barbiturate used to treat alcohol withdrawal and epilepsy. Acute overdoses present with varying levels of central nervous system depression and large overdoses can be life threatening.
Justin Seltzer, Jeremy Hardin, Henrik Galust, Nathan Friedman, Bryan Corbett, Richard F. Clark   +5 more
doaj  

Dupuytren's contracture as result of prolonged administration of phenobarbital. [PDF]

, 2011
Dupuytren's disease is a fibroproliferative condition involving the superficial palmar fascia, leading to a progressive and irreversible flexion of the fingers.
CORDOVA, Adriana, MOSCHELLA, Francesco, Tripoli, M   +2 more
core  

Sedative Effects of Intraperitoneal Diazepam in Mice

International Journal of Integrated Health Sciences, 2023
Objectives: To determine the effectiveness of Diazepam in comparison with Phenobarbital. Methods: Twenty-seven male Swiss Webster mice were used and randomly divided into three groups of negative control (NS), positive control (Phenobarbital), and ...
Marsha Vania, Shinta Dewi Permata Sari, Bambang Siswitono, Endin Nokik Stujanna   +3 more
doaj  

A novel UGT1A1 gene mutation causing severe unconjugated hyperbilirubinemia: a case report

BMC Pediatrics, 2019
Background Crigler-Najjar syndrome (CNs) presents as unconjugated hyperbilirubinemia, as a result of UGT1A1 deficiency, and can be categorized in a severe (type I) and mild (type II) phenotype.
Xiaoxia Shi, Sem Aronson, Ahmed Sharif Khan, Piter J. Bosma   +3 more
doaj   +1 more source