Results 71 to 80 of about 55,451 (338)
An Enrichment Method for Obtaining Biologically Significant Genes from Statistically Significant Differentially Expressed Genes in Comparative Transcriptomics [PDF]
arXiv, 2017 Cells coordinate adjustments in genome expression to accommodate changes in their environment. A drug in culture media for in vitro preclinical testing sometimes cause drastic regime shifting of genome expression system depending on the concentrations; e.g.
arxiv
Phenobarbital Therapy for Alcohol Withdrawal [PDF]
, 2021 For the treatment of alcohol withdrawal syndrome (AWS), phenobarbital works differently than benzodiazepines. Benzodiazepines activate only gamma-aminobutyric acid (GABA) whereas phenobarbital has the additional mechanism of inhibiting glutamate ...
Alcenius, Gay +4 more
core +1 more source
Elucidation of differential response networks from toxicogenomics data [PDF]
arXiv, 2008 We describe a novel approach to the analysis of toxicogenomics data and elucidation of biological networks affected by drug treatments. In this method approximately 15,000 linear pathway modules were generated from manually assembled pathway maps from MetaCore (GeneGo, Inc.).
arxiv
Metabolism of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) atropisomers in tissue slices from phenobarbital or dexamethasone-induced rats is sex-dependent. [PDF]
, 2013 1. Chiral polychlorinated biphenyls (PCBs) such as PCB 136 enantioselectively sensitize the ryanodine receptor (RyR). In light of recent evidence that PCBs cause developmental neurotoxicity via RyR-dependent mechanisms, this suggests that ...
Chen, Hao +7 more
core +1 more source
Advanced Biology, EarlyView.In this study, the authors show that osteocytes, mechanosensing cells embedded within bone, can indeed regulate prostate cancer cell extravasation through a blood vessel using a physiologically relevant tissue model. Specifically, it is shown that osteocytes modulate the expression of blood vessel cell adhesion molecules, affecting the frequency at ...
Kimberly Seaman +7 more
wiley +1 more source
Suspected phenobarbital-induced fever in a cat
Journal of Feline Medicine and Surgery Open Reports, 2019 Case summary A 3-year-old spayed female domestic shorthair cat developed a fever 1 week after starting the anticonvulsant phenobarbital. A diagnostic work-up for seizures and subsequent onset of fever of unknown origin, consisting of MRI of the brain ...
Dylan M Djani, William E Draper
doaj +1 more source
Bumetanide enhances phenobarbital efficacy in a rat model of hypoxic neonatal seizures. [PDF]
PLoS ONE, 2013 Neonatal seizures can be refractory to conventional anticonvulsants, and this may in part be due to a developmental increase in expression of the neuronal Na(+)-K(+)-2 Cl(-) cotransporter, NKCC1, and consequent paradoxical excitatory actions of GABAA ...
Ryan T Cleary +11 more
doaj +1 more source
Buprenorphine in Neonatal Abstinence Syndrome. [PDF]
, 2018 Infants exposed in utero to opioids will demonstrate a withdrawal syndrome known as neonatal abstinence syndrome (NAS). Buprenorphine is a long-acting opioid with therapeutic use in medication-assisted treatment of opioid dependency in adults and ...
Kraft, Walter K.
core +1 more source
Advanced Functional Materials, EarlyView.Translation of recombinant spider silks as fillers for nerve guidance conduits in long‐segment nerve reconstruction demands a detailed examination of native counterparts. Thus, this study conducts a comprehensive analysis of the material properties of four phylogenetically diverse spider silks and their impact on Schwann cell adhesion, pinpointing key ...
Sarah Stadlmayr +10 more
wiley +1 more source
The immunolocalization of HIF‐2α, GLUT1 and CAIX in porcine oviduct during the estrous cycle
The Anatomical Record, Volume 306, Issue 1, Page 176-186, January 2023., 2023 Abstract Oxygen (O2) rates in the oviduct are essential to human and animal reproduction. These rates are regulated by the activity of hypoxia markers such as the hypoxia‐inducible factors (HIFs), the glucose transporters (GLUT), and the carbonic anhydrase (CA).
Ester Párraga‐Ros +4 more
wiley +1 more source