Results 101 to 110 of about 3,784 (223)

Early Autonomic Burden in Prodromal Parkinson's Disease Predicts Cognitive Impairment

Movement Disorders, EarlyView.
Abstract Background Autonomic dysfunction is a known contributor to cognitive impairment in Parkinson's disease (PD), but its impact during prodromal stage is unknown. Objective The aim was to determine whether early autonomic burden predicts incident cognitive impairment in prodromal PD.
A. Enrique Martinez‐Nunez, Kelly A. Mills, Joseph Seemiller, Christopher B. Morrow, Gregory M. Pontone, Abhimanyu Mahajan   +5 more
wiley   +1 more source

Uncoupling TGFβ1 signalling from collagen protein synthesis in Dupuytren's disease

The Journal of Pathology, EarlyView.
Abstract Dupuytren's disease is a fibroproliferative disorder of the palmer fascia (PF) characterised by flexion contractures in the hand. Dupuytren's disease can be treated surgically, but disease recurrence rates are high, potentially due to continual production of matrisomal proteins.
Gabriella Cooper, Jade A Gumbs, Sahem Alkharabsheh, Katie J Lee, Alan Carter, Hannah Coleman, Niamh S O'Heneghan‐Yates, Rama Ijaz, Emma Beamish, Lisa A Menezes, Triantafillos Liloglou, Peter D Clegg, Elizabeth G. Canty‐Laird   +12 more
wiley   +1 more source

CYP2C19 genotype testing for clopidogrel: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)

British Journal of Clinical Pharmacology, Volume 92, Issue 2, Page 329-347, February 2026.
Clopidogrel, an antiplatelet agent, is currently licensed in the United Kingdom for the prevention and treatment of atherothrombotic events in cerebrovascular disease, coronary artery disease and peripheral arterial disease. Clopidogrel requires metabolic activation by the cytochrome P450 enzyme CYP2C19 to be effective.
Cinzia Dello Russo, Iain Frater, Rebecca Kuruvilla, Stefanie Lip, Hannah O'Neill, Kerry Burke, Vicky Chaplin, Alexander S. F. Doney, Salim Elyas, Nicholas Greaves, Sophie Harding, David Hargroves, Judith Hayward, Dyfrig A. Hughes, Tom A. T. Hughes, Sree Kondapally, Patrick Mok, Aaron Peace, Imran Rafi, Simon Ray, Vicky Stinton, Luigi Venetucci, Munir Pirmohamed   +22 more
wiley   +1 more source

Investigating hippocampal hyperexcitability as a biomarker of Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue S2, December 2025.
Abstract Background Hippocampal hyperexcitability is an early feature of Alzheimer's disease (AD) that may drive pathology. However, current models of AD risk focusing on the A/T/N framework (Aβ /Tau/Neurodegeneration) do not include hyperexcitability as a key disease biomarker.
Casey R Vanderlip, Jenna N. Adams
wiley   +2 more sources

Clinical Implementation of Pharmacogenomics and Drug–Drug Interaction Screening in a German Academic Teaching Hospital and Outpatient Follow‐Up

Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 241-254, January 2026.
Overview of the implemented pharmacogenomics (PGx) process in clinical routine at the Robert Bosch Hospital: from patient enrollment via the hospital information system, DNA detection using a customized TaqMan OpenArray panel and qPCR for CNV assessment, to clinical translation of genotyping results into PGx guideline‐based recommendations using a ...
Roman Tremmel, Filippa Schreeck, Simon Jaeger, Severin Schricker, Elke Schaeffeler, Svitlana Igel, Daniela Steinberger, Manuel Pagitz, Jörg Latus, Markus Ketteler, Kerstin Bühl, Marc‐H. Dahlke, Hans‐Georg Kopp, Matthias Schwab   +13 more
wiley   +1 more source

Longitudinal evolution of cortical thickness signature reflecting Lewy body dementia in isolated REM sleep behavior disorder: a prospective cohort study

Translational Neurodegeneration, 2023
Background The isolated rapid-eye-movement sleep behavior disorder (iRBD) is a prodromal condition of Lewy body disease including Parkinson's disease and dementia with Lewy bodies (DLB).
Jung Hwan Shin, Heejung Kim, Yu Kyeong Kim, Eun Jin Yoon, Hyunwoo Nam, Beomseok Jeon, Jee-Young Lee   +6 more
doaj   +1 more source

뇌파를 이용한 단독 렘수면행동장애의 시누클레인병증 발병 시기 및 아형 예측을 위한 기계 학습 모델 [PDF]

, 2023
학위논문(석사) -- 서울대학교대학원 : 공과대학 협동과정 바이오엔지니어링전공, 2023. 2. 정기영.Objective: Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal disease of α-synucleinopathies, and more than 80% of cases eventually convert to neurodegenerative diseases ...
정엘
core  

Self‐Reported Pharmacogenetic Medication Use in the Our Future Health Cohort

Clinical and Translational Science, Volume 19, Issue 1, January 2026.
ABSTRACT The aim of this study was to describe self‐reported use of medications with established pharmacogenetic guidance in the Our Future Health (OFH) cohort. We examined four key pharmacogenes—CYP2C19, CYP2C9, CYP2D6, and SLCO1B1—and medications supported by strong evidence for clinical actionability according to the Clinical Pharmacogenetics ...
Padraig Dixon, William G. Newman, Videha Sharma, John H. McDermott, Cynthia Wright Drakesmith   +4 more
wiley   +1 more source

Bacterial challenge-associated metabolic phenotypes in Hermetia illucens defining nutritional and functional benefits

Scientific Reports, 2021
Black soldier fly (BSF, Hermetia illucens) is popular for its applications in animal feed, waste management and antimicrobial peptide source. The major advantages of BSF larva include their robust immune system and high nutritional content that can be ...
Phuc N. Ho, Poramate Klanrit, Yupa Hanboonsong, Umaporn Yordpratum, Manida Suksawat, Thanaporn Kulthawatsiri, Anyarin Jirahiranpat, Suthicha Deewai, Panya Mackawan, Rasana W. Sermswan, Nisana Namwat, Watcharin Loilome, Tueanjit Khampitak, Arporn Wangwiwatsin, Jutarop Phetcharaburanin   +14 more
doaj   +1 more source

Oxidative Stress—Related Serum Extracellular Vesicle miRNAs Indicate Symptom Severity and Cognitive Decline in Parkinson's Disease

Journal of Neurochemistry, Volume 170, Issue 1, January 2026.
Oxidative stress and mitochondrial dysfunction are core mechanisms to dopaminergic neuronal death in Parkinson's disease (PD) and are regulated by microRNAs such as miR‐24‐3p, miR‐103a‐3p, miR‐320a‐3p, miR‐494‐3p, miR‐126‐5p, and miR‐543. Their expression was analyzed in serum extracellular vesicles of 93 PD patients by RT‐qPCR, as well as correlations
Violeta Belickienė, Aistė Pranckevičienė, Andrius Radžiūnas, Andrėja Strigauskaitė, Ovidijus Laucius, Paulina Vaitkienė   +5 more
wiley   +1 more source