Results 121 to 130 of about 3,784 (223)
Defining pre-symptomatic amyotrophic lateral sclerosis [PDF]
, 2019 Successful treatment of neurodegenerative disease may hinge on early therapeutic intervention. This requires an understanding of early/pre-symptomatic disease, a need that is underscored by advances in antisense oligonucleotide, and viral-vector-based ...
Benatar, M, Turner, Martin, Wuu, J
core +2 more sources
A protective role for N-acylphosphatidylethanolamine phospholipase D in 6-OHDA-induced neurodegeneration. [PDF]
, 2019 N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) catalyzes the cleavage of membrane NAPEs into bioactive fatty-acid ethanolamides (FAEs). Along with this precursor role, NAPEs might also serve autonomous signaling functions. Here, we report that
Palese, Francesca +3 more
core
Autophagy in phenoconversion of differentiated and undifferentiated fibroblasts
The FASEB Journal, 2013 Cardiac fibroblasts phenoconvert to hypersecretory myofibroblasts and deposit matrix resulting in cardiac fibrosis and autophagy that is associated to fibroproliferative events. Autophagy inhibition was studied in both primary (P0) rat cardiac fibroblasts (PF) and mouse embryonic fibroblasts (MEF).
Shivika Gupta +6 more
openaire +1 more source
Frontiers in PharmacologyEscitalopram is widely regarded as a well-tolerated selective serotonin reuptake inhibitor (SSRI) with a favorable safety profile. However, severe adverse events can occur even at therapeutic doses in susceptible individuals.
Zongchen Jiang +6 more
doaj +1 more source
Colloidal nanoparticles as advanced biological sensors
, 2014 Biological sensing using nanoparticles Colloidal fluorescent and plasmonic nanoparticles yield intense responses to incident light, making them useful as sensors or probes for sensitive detection in solution.
Chandrawati, R, Howes, PD, Stevens, MM
core +1 more source
Phenoconversion Due to Drug–Drug Interactions in CYP2C19 Genotyped Healthy Volunteers
Clinical pharmacology and therapyTo compensate for drug response variability, drug metabolism phenotypes are determined based on the results of genetic testing, and if necessary, drug dosages are adjusted.
Kenza Abouir +4 more
semanticscholar +1 more source
NODDI reveals white matter microstructural changes in isolated REM sleep behavior disorder
Alzheimer's &Dementia, Volume 21, Issue S2, December 2025.Abstract Background Isolated REM sleep behavior disorder (iRBD) is a parasomnia that reflects an evolving α‐synucleinopathy disorder, providing an opportunity to study early pathological changes. While diffusion tensor imaging (DTI) studies have shown white matter changes in iRBD, Neurite Orientation Dispersion and Density Imaging (NODDI) may offer ...
Elijah Mak +50 more
wiley +1 more source
CXCL12/CXCR4-Mediated Procollagen Secretion Is Coupled To Cullin-RING Ubiquitin Ligase Activation
Scientific Reports, 2018 Tissue fibrosis is mediated by the actions of multiple pro-fibrotic proteins that can induce myofibroblast phenoconversion through diverse signaling pathways coupled predominantly to Smads or MEK/Erk proteins.
Susan Patalano +7 more
doaj +1 more source
Brain and Behavior, Volume 15, Issue 12, December 2025.Using data from the PPMI cohort, including 1,269 individuals with prodromal PD features (isolated RBD: n = 116, isolated hyposmia: n = 570, combined: n = 583) and 284 healthy controls, we found that in prodromal PD, NLR was elevated, primarily due to reduced lymphocyte counts, and this increase was associated with greater motor severity.
Jin‐Sun Jun +4 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, Volume 118, Issue 6, Page 1430-1436, December 2025.Hydralazine is a vasodilator typically used in the treatment of resistant hypertension and heart failure. N‐acetyltransferase 2 (NAT2) catalyzes the metabolism of hydralazine into inactive metabolites. NAT2 poor metabolizers (historically referred to as “slow acetylators”) are predicted to have increased plasma hydralazine concentrations compared with ...
Michael T. Eadon +18 more
wiley +1 more source