Predicting Phenoconversion in Isolated RBD: Machine Learning and Explainable AI Approach [PDF]
Clocks & SleepIsolated rapid eye movement (REM) sleep behavior disorder (iRBD) is recognized as a precursor to neurodegenerative diseases. This study aimed to develop predictive models for the timing and subtype of phenoconversion in iRBD.
Yong-Woo Shin +6 more
doaj +7 more sources
Longitudinal network changes and phenoconversion risk in isolated REM sleep behavior disorder [PDF]
Nature CommunicationsIsolated rapid eye movement sleep behavior disorder is a prodrome of α-synucleinopathies. Using positron emission tomography, we assessed changes in Parkinson’s disease-related motor and cognitive metabolic networks and caudate/putamen dopaminergic input
Chris C. Tang +13 more
doaj +10 more sources
Multimodal Autonomic Biomarkers Predict Phenoconversion in Pure Autonomic Failure [PDF]
Annals of Clinical and Translational NeurologyBackground Pure autonomic failure (PAF) presents with autonomic failure without other neurological features. A third develop central neurological features, fulfilling criteria for multiple system atrophy (MSA) and Lewy body diseases (LBD), including ...
S. Koay +12 more
doaj +4 more sources
Factors associated with phenoconversion of idiopathic rapid eye movement sleep behavior disorder: a prospective study [PDF]
npj Parkinson's DiseaseThis study explores the effect of risk factors on the progression of idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) to α-synucleinopathies in a Chinese cohort.
Yuan Yuan +9 more
doaj +5 more sources
Effect of CYP2D6, 2C19, and 3A4 Phenoconversion in Drug-Related Deaths [PDF]
ToxicsMolecular autopsy is a very important tool in forensic toxicology. However, many determinants, such as co-medication and physiological parameters, should be considered for optimal results.
Sanaa M. Aly +3 more
doaj +6 more sources
CXC-type chemokines promote myofibroblast phenoconversion and prostatic fibrosis. [PDF]
PLoS ONE, 2012 Recent studies from our group suggest that extracellular matrix (ECM) deposition and fibrosis characterize the peri-urethral prostate tissues of some men suffering from Lower Urinary Tract Symptoms (LUTS) and that fibrosis may be a contributing factor to
Mehrnaz Gharaee-Kermani +5 more
doaj +5 more sources
Inflammation-mediated Phenoconversion: A Potential Threat to COVID-19 Pharmacotherapy [PDF]
Hayati Journal of Biosciences, 2021 One of the important hallmarks of coronavirus disease 2019 (COVID-19) is the existence of severe inflammatory responses. Many reports indicated that inflammatory mediators might suppress the biological functions of some drug metabolizing enzymes and ...
Muh. Akbar Bahar +3 more
doaj +6 more sources
Pharmacogenetics and phenoconversion: the influence on side effects experienced by psychiatric patients [PDF]
Frontiers in Genetics, 2023 Introduction: Preventing side effects is important to ensure optimal psychopharmacotherapy and therapeutic adherence among psychiatric patients. Obtaining the pharmacogenetic profile of CYP2C19 and CYP2D6 can play an important role in this.
Manon G. den Uil +9 more
doaj +7 more sources
CD4+ T-cell transcription factors as early predictors of phenoconversion in idiopathic rapid eye movement sleep behaviour disorder [version 2; peer review: 2 approved] [PDF]
F1000ResearchIn this datanote we present data from 31 iRBD (idiopathic Rapid eye movement (REM) sleep Behaviour Disorder) patients followed throughout three years to assess their eventual phenoconversion to Parkinson’s disease and other established neurodegenerative ...
Maurizio Versino +5 more
doaj +3 more sources
Solanidine-derived CYP2D6 phenotyping elucidates phenoconversion in multimedicated geriatric patients. [PDF]
Br J Clin PharmacolAims Phenoconversion, a genotype‐phenotype mismatch, challenges a successful implementation of personalized medicine. The aim of this study was to detect and determine phenoconversion using the solanidine metabolites 3,4‐seco‐solanidine‐3,4‐dioic acid ...
Sarömba JA +9 more
europepmc +6 more sources