Results 11 to 20 of about 1,759 (167)

Pharmacogenetics and phenoconversion: the influence on side effects experienced by psychiatric patients [PDF]

Frontiers in Genetics, 2023
Introduction: Preventing side effects is important to ensure optimal psychopharmacotherapy and therapeutic adherence among psychiatric patients. Obtaining the pharmacogenetic profile of CYP2C19 and CYP2D6 can play an important role in this.
Manon G. den Uil, Hannelotte W. Hut, Kay R. Wagelaar, Kay R. Wagelaar, Heshu Abdullah-Koolmees, Heshu Abdullah-Koolmees, Wiepke Cahn, Ingeborg Wilting, Vera H. M. Deneer, Vera H. M. Deneer   +9 more
doaj   +7 more sources

Resveratrol-Mediated Repression and Reversion of Prostatic Myofibroblast Phenoconversion. [PDF]

PLoS ONE, 2016
Resveratrol, a phytoalexin found in berries, peanuts, grapes, and red wine, inhibits oxidation, inflammation, and cell proliferation and collagen synthesis in multiple cell types and or animal models.
Mehrnaz Gharaee-Kermani, Bethany B Moore, Jill A Macoska   +2 more
doaj   +6 more sources

Case report: Therapeutic drug monitoring and CYP2D6 phenoconversion in a protracted paroxetine intoxication

Frontiers in Pharmacology
ObjectiveThe cytochrome P450 2D6 (CYP2D6) is an enzyme involved in the oxidative biotransformation of various widely used drugs, including paroxetine, a substrate and strong inhibitor of the enzyme.
Alena Damborská, Alena Damborská, Lenka Hanáková, Eva Pindurová, Eva Pindurová, Kateřina Horská, Kateřina Horská   +6 more
doaj   +4 more sources

Solanidine-derived CYP2D6 phenotyping elucidates phenoconversion in multimedicated geriatric patients. [PDF]

Br J Clin Pharmacol
AbstractAimsPhenoconversion, a genotype‐phenotype mismatch, challenges a successful implementation of personalized medicine. The aim of this study was to detect and determine phenoconversion using the solanidine metabolites 3,4‐seco‐solanidine‐3,4‐dioic acid (SSDA) and 4‐OH‐solanidine as diet‐derived cytochrome P450 2D6 (CYP2D6) biomarkers in a ...
Sarömba JA, Müller JP, Tupiec J, Roeth A, Kurt B, Kahles F, Laurentius T, Bollheimer C, Stingl JC, Just KS.   +9 more
europepmc   +7 more sources

CXC-type chemokines promote myofibroblast phenoconversion and prostatic fibrosis. [PDF]

PLoS ONE, 2012
Recent studies from our group suggest that extracellular matrix (ECM) deposition and fibrosis characterize the peri-urethral prostate tissues of some men suffering from Lower Urinary Tract Symptoms (LUTS) and that fibrosis may be a contributing factor to
Mehrnaz Gharaee-Kermani, Sathish Kasina, Bethany B Moore, Dafydd Thomas, Rohit Mehra, Jill A Macoska   +5 more
doaj   +5 more sources

CD4+ T-cell transcription factors as early predictors of phenoconversion in idiopathic rapid eye movement sleep behaviour disorder [version 2; peer review: 2 approved] [PDF]

F1000Research
In this datanote we present data from 31 iRBD (idiopathic Rapid eye movement (REM) sleep Behaviour Disorder) patients followed throughout three years to assess their eventual phenoconversion to Parkinson’s disease and other established neurodegenerative ...
Maurizio Versino, Cristoforo Comi, Franca Marino, Michele Terzaghi, Monica Pinoli, Marco Cosentino   +5 more
doaj   +2 more sources

Plasma p-tau217 and Aβ42/40 as markers of Aβ pathology in the Lewy body continuum. [PDF]

Alzheimers Dement
Abstract INTRODUCTION This study evaluated whether plasma phosphorylated tau‐217 (p‐tau217), amyloid beta (Aβ)42/40, and their combination could serve as biomarkers of Aβ co‐pathology across the Lewy body continuum, where Aβ is frequently observed from prodromal to symptomatic stages.
Woo KA, Yoon EJ, Kim R, Kim H, Kim S, Jin B, Lee S, Kim YK, Nam H, Lee JY.   +9 more
europepmc   +2 more sources

Inflammation-mediated Phenoconversion: A Potential Threat to COVID-19 Pharmacotherapy

Hayati Journal of Biosciences, 2021
One of the important hallmarks of coronavirus disease 2019 (COVID-19) is the existence of severe inflammatory responses. Many reports indicated that inflammatory mediators might suppress the biological functions of some drug metabolizing enzymes and ...
Muh. Akbar Bahar, Bob Wilffert, Harapan Harapan, Firzan Nainu   +3 more
doaj   +4 more sources

Functional Magnetic Resonance Imaging (fMRI) Signatures of Progression and Phenoconversion in Prodromal Synucleinopathies [PDF]

Movement Disorders, EarlyView.
Abstract Background Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is a prodromal manifestation of synucleinopathies and provides a critical window to identify early markers of progression to Parkinson's disease (PD) and dementia with Lewy bodies (DLB).
L. Churchill, Anna Ignatavicius, Ajay Konuri, Jack Anderson, Natasha L. Taylor, Simon J.G. Lewis, Elie Matar   +6 more
openalex   +2 more sources

Progression trajectories from prodromal to overt synucleinopathies: a longitudinal, multicentric brain [18F]FDG-PET study [PDF]

npj Parkinson's Disease
The phenoconversion trajectory from idiopathic/isolated Rapid eye movement (REM) sleep behavior disorder (iRBD) towards either Parkinson’s Disease (PD) or Dementia with Lewy Bodies (DLB) is currently uncertain.
Beatrice Orso, Pietro Mattioli, Eun-Jin Yoon, Yu Kyeong Kim, Heejung Kim, Jung Hwan Shin, Ryul Kim, Francesco Famà, Andrea Brugnolo, Federico Massa, Agostino Chiaravalloti, Mariana Fernandes, Matteo Spanetta, Fabio Placidi, Matteo Pardini, Matteo Bauckneht, Silvia Morbelli, Jee-Young Lee, Claudio Liguori, Dario Arnaldi   +19 more
doaj   +2 more sources