Results 21 to 30 of about 3,784 (223)

Phenoconversion of CYP3A4, CYP2C19 and CYP2D6 in Pediatrics, Adolescents and Young Adults With Lymphoma: Rationale and Design of the PEGASUS Study [PDF]

Clinical and Translational Science
Phenoconversion is the discrepancy between genotype‐predicted phenotype and clinical phenotype, due to nongenetic factors. In oncology patients, the impact of phenoconversion on drug selection, efficacy, toxicity, and treatment outcomes is unknown.
Rachel Conyers, Tayla Stenta, Andrew A. Somogyi, Carl Kirkpatrick, Andreas Halman, Sophie Wang, Claire Moore, Dhrita Khatri, Elizabeth Williams, Roxanne Dyas, Tim Spelman, David A. Elliott, Amanda Gwee, Marliese Alexander   +13 more
doaj   +3 more sources

Association of DTI-ALPS Glymphatic Index With Differential Phenoconversion in Isolated REM Sleep Behavior Disorder: A Multi-Cohort MRI Study. [PDF]

Neurology
Background and Objectives Isolated REM sleep behavior disorder (iRBD) is the strongest prodromal marker of synucleinopathies, including Parkinson disease (PD) and dementia with Lewy bodies (DLB).
Ayral V, Pastor-Bernier A, Daneault V, Tremblay C, Filiatrault M, Haddad C, Gagnon JF, Postuma RB, Dušek P, Marecek S, Varga Z, Klein JC, Hu MT, Lehéricy S, Arnulf I, Vidailhet M, Corvol JC, ICEBERG Study Group, Rahayel S.   +18 more
europepmc   +4 more sources

Prevalence Estimates of Cytochrome P450 Phenoconversion in Youth Receiving Pharmacotherapy for Mental Health Conditions. [PDF]

Clin Pharmacol Ther
Pharmacogenetics‐predicted drug metabolism may not match clinically observed metabolism due to a phenomenon known as phenoconversion. Phenoconversion can occur when an inhibitor or inducer of a drug‐metabolizing enzyme is present.
Gerlach S, Maruf AA, Shaheen SM, McCloud R, Heintz M, McAusland L, Arnold PD, Bousman CA.   +7 more
europepmc   +4 more sources

Machine Learning Predicts Phenoconversion from Polysomnography in Isolated REM Sleep Behavior Disorder [PDF]

Brain Sciences
Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is a prodromal stage of alpha-synucleinopathies. This study aimed at developing a fully-automated machine learning framework for the prediction of phenoconversion in patients with iRBD by ...
Matteo Cesari, Andrea Portscher, Ambra Stefani, Raphael Angerbauer, Abubaker Ibrahim, Elisabeth Brandauer, Simon Feuerstein, Kristin Egger, Birgit Högl, Antonio Rodriguez-Sanchez   +9 more
doaj   +3 more sources

Cholinergic dysfunction in isolated rapid eye movement sleep behaviour disorder links to impending phenoconversion [PDF]

European Journal of Neurology
Background and purpose: Most patients with isolated rapid eye movement sleep behaviour disorder (iRBD) progress to a parkinsonian alpha-synucleinopathy. However, time to phenoconversion shows great variation.
Baun, Andreas M., Borghammer, Per, Brooks, David J., Danielsen, Erik Hvid, Gaig Ventura, Carles, Garrido, Alicia, Iranzo, Alex, Johnsen, Erik L., Møller, Arne, Møller, Mette, Otto, Maritt, Pavese, Nicola, Santamaria Cano, Joan, Serradell, Mónica, Stokholm, Morten G., Svendsen, Kristina B., Terkelsen, Miriam H., Tolosa, Eduardo, Vilas Rolán, Dolores, Østergaard, Karen   +19 more
core   +7 more sources

Resveratrol-Mediated Repression and Reversion of Prostatic Myofibroblast Phenoconversion. [PDF]

PLoS ONE, 2016
Resveratrol, a phytoalexin found in berries, peanuts, grapes, and red wine, inhibits oxidation, inflammation, and cell proliferation and collagen synthesis in multiple cell types and or animal models.
Mehrnaz Gharaee-Kermani, Bethany B Moore, Jill A Macoska   +2 more
doaj   +5 more sources

Dasatinib-induced nephrotic syndrome: a case of phenoconversion? [PDF]

Croatian Medical Journal, 2019
We present the case of a 33-year-old chronic myeloid leukemia (CML) female patient, in whom the occurrence of nephrotic syndrome, during the treatment with tyrosine kinase activity inhibitors (TKIs), was potentially influenced by transient ...
Alen Juginović, Borna Arsov, Dragan Primorac, Inga Mandac Rogulj, Luka Boban, Vid Matišić, Vilim Molnar   +6 more
core   +10 more sources

CD4+ T-cell transcription factors predict phenoconversion in idiopathic rapid eye movement sleep behavior disorder

Future Science OA
Aim: Early biomarkers of phenoconversion to neurodegeneration are crucial to identify individuals at high risk. In patients with idiopathic REM sleep behavior disorder (iRBD), the strongest risk factor for neurodegeneration, CD4+ T cells exhibit a ...
Monica Pinoli, Michele Terzaghi, Franca Marino, Cristoforo Comi, Maurizio Versino, Marco Cosentino   +5 more
doaj   +3 more sources

Understanding variation in metoprolol response: CYP2D6, drug interactions, and phenoconversion.

Pharmacogenomics (London)
Metoprolol, a β1-selective blocker, is widely used for treating cardiovascular and non-cardiovascular conditions. Its pharmacokinetics (PK) and pharmacodynamics (PD) vary significantly between individuals, in part due to CYP2D6 genetic polymorphisms.
Bayan Azizi, D. Lanfear, Jasmine A. Luzum   +2 more
semanticscholar   +4 more sources

The Evaluation of CYP2D6, CYP2C9, CYP2C19, and CYP2B6 Phenoconversion in Post-Mortem Casework: The Challenge of Forensic Toxicogenetics [PDF]

Metabolites, 2023
In toxicogenetics, an integrative approach including the prediction of phenotype based on post-mortem genotyping of drug-metabolising enzymes might help explain the cause of death (CoD) and manner of death (MoD).
Arianna Giorgetti, Sara Amurri, Giulia Fazio, Carla Bini, Laura Anniballi, Filippo Pirani, Guido Pelletti, Susi Pelotti   +7 more
doaj   +3 more sources