Results 41 to 50 of about 1,759 (167)
REM Sleep Behaviour Disorder in Multiple System Atrophy: From Prodromal to Progression of Disease
Frontiers in Neurology, 2021 A higher frequency of motor and breathing sleep-related disorders in multiple system atrophy (MSA) populations is reported. REM sleep behaviour disorder (RBD) is one of the most robust markers of an underlying alpha-synucleinopathy.
Giulia Giannini +7 more
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Multimodal imaging in familial FTLD: phenoconversion and planning for the future [PDF]
Brain, 2018 This scientific commentary refers to ‘Longitudinal multimodal MRI as prognostic and diagnostic biomarker in presymptomatic familial frontotemporal dementia’, by Jiskoot et al. (doi:10.1093/brain/awy288).
Bradley F. Boeve, Howard J. Rosen
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The Relevance of Integrating CYP2C19 Phenoconversion Effects into Clinical Pharmacogenetics [PDF]
PharmacopsychiatryAbstract Introduction CYP2D6 and CYP2C19 functional status as defined by genotype is modulated by phenoconversion (PC) due to pharmacokinetic interactions. As of today, there is no data on the effect size of PC for CYP2C19 functional status.
Maike Scherf‐Clavel +7 more
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CYP450 Genotype—Phenotype Concordance Using the Geneva Micrococktail in a Clinical Setting
Frontiers in Pharmacology, 2021 Pharmacokinetic variability is a major source of differences in drug response and can be due to genetic variants and/or drug-drug interactions. Cytochromes P450 are among the most studied enzymes from a pharmacokinetic point of view.
Kuntheavy Ing Lorenzini +6 more
doaj +1 more source
Medicina, 2023 Pharmacotherapy for major depressive disorder (MDD) typically consists of trial-and-error and clinician preference approaches, where patients often fail one or more antidepressants before finding an optimal regimen.
Joshua Russell +6 more
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Phenoconversion of CYP2D6 by inhibitors modifies aripiprazole exposure [PDF]
European Archives of Psychiatry and Clinical Neuroscience, 2019 The efficacy of aripiprazole therapy and the risk of adverse reactions are influenced by substantial inter-individual variability in aripiprazole metabolizing capacity. In vitro studies assigned the potential role in aripiprazole metabolism to CYP2D6 and CYP3A enzymes; therefore, the association between the steady-state aripiprazole plasma ...
Ádám Kiss +9 more
openaire +4 more sources
Dasatinib-induced nephrotic syndrome: a case of phenoconversion?
Croatian Medical Journal, 2019 We present the case of a 33-year-old chronic myeloid leukemia (CML) female patient, in whom the occurrence of nephrotic syndrome, during the treatment with tyrosine kinase activity inhibitors (TKIs), was potentially influenced by transient phenoconversion.
Mandac Rogulj, Inga +6 more
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Cardiosomal microRNAs Are Essential in Post-Infarction Myofibroblast Phenoconversion [PDF]
International Journal of Molecular Sciences, 2019 The inclusion of microRNAs (miRNAs) in extracellular microvesicles/exosomes (named cardiosomes when deriving from cardiomyocytes) allows their active transportation and ensures cell-cell communication. We hypothesize that cardiosomal miRNAs play a pivotal role in the activation of myofibroblasts following ischemic injury.
Morelli Marco Bruno +4 more
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Response to “Methodological Considerations on CYP2D6 Phenoconversion Due to Drug‐Drug Interaction” [PDF]
Clinical Pharmacology & Therapeutics, 2019 Kelsey West, Andrew A. Monte
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Medicina, 2021 Pharmacogenomic (PGx) information can guide drug and dose selection, optimize therapy outcomes, and/or decrease the risk of adverse drug events (ADEs). This report demonstrates the impact of a pharmacist-led medication evaluation, with PGx assisted by a ...
Nicole Marie Del Toro-Pagán +5 more
doaj +1 more source