Results 41 to 50 of about 3,784 (223)

Ovarian Cancer Cell-Conditioning Medium Induces Cancer-Associated Fibroblast Phenoconversion through Glucose-Dependent Inhibition of Autophagy [PDF]

International Journal of Molecular Sciences
One aspect of ovarian tumorigenesis which is still poorly understood is the tumor–stroma interaction, which plays a major role in chemoresistance and tumor progression.
Alessandra Ferraresi, Carlo Girone, Chinmay Maheshwari, Letizia Vallino, D. Dhanasekaran, C. Isidoro   +5 more
semanticscholar   +2 more sources

Free water predicts dementia with Lewy bodies in isolated REM sleep behavior disorder. [PDF]

Alzheimers Dement
INTRODUCTION: Most individuals with isolated rapid eye movement sleep behavior disorder (iRBD) develop dementia with Lewy bodies (DLB) or Parkinson's disease (PD). Brain biomarkers predicting specific phenoconversion trajectories are lacking. METHODS: In
Haddad C, Daneault V, Ayral V, Filiatrault M, Pastor-Bernier A, Tremblay C, Boré A, Descoteaux M, Vo A, Gagnon JF, Postuma RB, Dusek P, Marecek S, Varga Z, Klein J, Hu MT, Lehéricy S, Arnulf I, Vidailhet M, Corvol JC, ICEBERG Study Group, Rahayel S.   +21 more
europepmc   +3 more sources

‘Phenoconversion’ in adult patients with β-thalassemia [PDF]

, 2023
To the Editor: Patients with clinically significant forms of β-thalassemia have been historically classified as having a β-thalassemia major or β-thalassemia intermedia phenotype, with the first primarily referring to patients who present with severe ...
Annamaria Pasanisi, Barbara Gianesin, Filomena Longo, Gian Luca Forni, Giovanni Battista Ferrero, Khaled M. Musallam, Lucia De Franceschi, Raffaella Origa, Roberto Lisi, Susanna Barella   +9 more
core   +2 more sources

Phenoconversion and therapeutic drug monitoring [PDF]

British Journal of Clinical Pharmacology, 2015
Keywords: clobazam; clozapine; genotype–phenotype mismatch; personalized medicine; pharmacogenetics; risperidone; therapeutic drug monitoring ...
José de León
openalex   +3 more sources

Predicting Phenoconversion to Clinically Manifest ALS: Results of a Large-Scale Proteomic Study

medRxiv
The study of pre-symptomatic amyotrophic lateral sclerosis (ALS) and the design of disease prevention trials are greatly hampered by our inability to predict which unaffected carriers of ALS-associated pathogenic variants will phenoconvert to clinically ...
Ximing Ran, J. Wuu, Zhaohui S Qin, Johnathan Cooper-Knock, V. Granit, Anne-Laure Grignon, Yindi Li, Eliza Lin, Maria Catalina Fernandez, Danielle Colato, N. Carberry, C. Lill, Paolo Piazza, Andrea Malaspina, M. Benatar   +14 more
semanticscholar   +3 more sources

Risk Factors for Phenoconversion in Rapid Eye Movement Sleep Behavior Disorder [PDF]

Annals of Neurology, 2022
Objective: This study was undertaken to follow up predictive factors for α-synuclein–related neurodegenerative diseases in a multicenter cohort of idiopathic/isolated rapid eye movement sleep behavior disorder (iRBD).
Arnulf I., Dauvilliers Y., Fantini M. L., Ferini-Strambi L., Figorilli M., Frauscher B., Hogl B., Ibrahim A., Iranzo A., Janzen A., Ju Y. -E., Leu-Semenescu S., Manni R., Miyamoto M., Miyamoto T., Montplaisir J. Y., Oertel W. H., Pelletier A., Postuma R. B., Puligheddu M., Sonka K., Stefani A., Terzaghi M., Zhang H., Zucconi M.   +24 more
core   +5 more sources

Functional Magnetic Resonance Imaging (fMRI) Signatures of Progression and Phenoconversion in Prodromal Synucleinopathies. [PDF]

Mov Disord
Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is a prodromal manifestation of synucleinopathies and provides a critical window to identify early markers of progression to Parkinson's disease (PD) and dementia with Lewy bodies (DLB ...
Churchill L, Ignatavicius A, Konuri A, Anderson J, Taylor N, Lewis SJG, Matar E.   +6 more
europepmc   +2 more sources

Pharmacogenomic insights in psychiatric care: uncovering novel actionability, allele-specific CYP2D6 copy number variation, and phenoconversion in 15,000 patients [PDF]

Molecular Psychiatry
Pharmacogenomic testing has emerged as an aid in clinical decision making for psychiatric providers, but more data is needed regarding its utility in clinical practice and potential impact on patient care. In this cross-sectional study, we determined the
Jai N. Patel, Sarah A Morris, Raul Torres, Brooke Rhead, Chris Vlangos, Daniel J Müller, Lisa Brown, Hailey B Lefkofsky, Muneer Ali, Francisco M De La Vega, Kathleen C. Barnes, Anthony Zoghbi, Joseph Stanton, Marcus A. Badgeley   +13 more
semanticscholar   +2 more sources

Sleep Disturbances and Phenoconversion in Patients with REM Sleep Behavior Disorder [PDF]

Journal of Clinical Medicine, 2021
Objective: We aimed to investigate relationships between sleep disturbances and phenoconversion to neurodegenerative diseases in patients with REM sleep behavior disorder (RBD). Method: Using a comprehensive sleep database in a university-affiliated hospital between December 2014 and March 2021, we reviewed the data of 226 patients with RBD (182 ...
Hyunjin Jo, Dongyeop Kim, Jooyeon Song, Su Jung Choi, Eun-Yeon Joo   +4 more
openalex   +4 more sources

Sex and age effects on prevalence of CYP2C19 and CYP2D6 Phenoconversion risk over time in patients with psychosis [PDF]

Progress in Neuro-psychopharmacology and Biological Psychiatry
Pharmacogenetics in psychiatry may have benefits for medication treatment success. However, medication regimes leading to drug-drug interactions and potential phenoconversion of actionable pharmacogenetic phenotypes challenge the application of ...
De Brabander, Emma Y., Leibold, Nicole K., van Amelsvoort, Thérèse, van Westrhenen, Roos   +3 more
core   +2 more sources