Results 51 to 60 of about 1,759 (167)

Neurologic and psychiatric features of impending neurodegeneration in iRBD

Clinical Parkinsonism & Related Disorders, 2023
Introduction: Idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) is linked to Parkinson’s disease and other alpha-synucleinopathies, but various subsets of iRBD may not carry equal risk (i.e., those with depression are at higher risk than
Daniel A. Barone, Harini Sarva, Natalie Hellmers, Fei Wang, Zhenxing Xu, Ana C. Krieger, Claire Henchcliffe   +6 more
doaj   +1 more source

A retrotransposon storm marks clinical phenoconversion to late-onset Alzheimer’s disease

GeroScience, 2022
AbstractRecent reports have suggested that the reactivation of otherwise transcriptionally silent transposable elements (TEs) might induce brain degeneration, either by dysregulating the expression of genes and pathways implicated in cognitive decline and dementia or through the induction of immune-mediated neuroinflammation resulting in the ...
Macciardi, Fabio, Giulia Bacalini, Maria, Miramontes, Ricardo, Boattini, Alessio, Taccioli, Cristian, Modenini, Giorgia, Malhas, Rond, Anderlucci, Laura, Gusev, Yuriy, Gross, Thomas J, Padilla, Robert M, Fiandaca, Massimo S, Head, Elizabeth, Guffanti, Guia, Federoff, Howard J, Mapstone, Mark   +15 more
openaire   +5 more sources

Cognitive profile in idiopathic autonomic failure: relation with white matter hyperintensities and neurofilament levels

Annals of Clinical and Translational Neurology, 2022
Objective To disclose the nature of cognitive deficits in a cohort of patients with idiopathic autonomic failure (IAF) by exploring the relation among cognitive functions, cardiovascular autonomic failure (AF) and clinical progression to another α ...
Ilaria Cani, Luisa Sambati, Fiorina Bartiromo, Gian Maria Asioli, Simone Baiardi, Laura M. B. Belotti, Giulia Giannini, Pietro Guaraldi, Corinne Quadalti, Luciano Romano, Raffaele Lodi, Piero Parchi, Pietro Cortelli, Caterina Tonon, Giovanna Calandra‐Buonaura   +14 more
doaj   +1 more source

Precision medication: An illustrative case series guiding the clinical application of multi‐drug interactions and pharmacogenomics

Clinical Case Reports, 2020
Precision medication entails selecting the precise medication, dose, and timing of administration. Multi‐drug interactions and genetics significantly affect precision medication. In this article, we present two simulated cases for real‐world applications
Kevin T. Bain, David McGain, Emily J. Cicali, Calvin H. Knowlton, Veronique Michaud, Jacques Turgeon   +5 more
doaj   +1 more source

Autophagy in phenoconversion of differentiated and undifferentiated fibroblasts

The FASEB Journal, 2013
Cardiac fibroblasts phenoconvert to hypersecretory myofibroblasts and deposit matrix resulting in cardiac fibrosis and autophagy that is associated to fibroproliferative events. Autophagy inhibition was studied in both primary (P0) rat cardiac fibroblasts (PF) and mouse embryonic fibroblasts (MEF).
Shu‐Ru Chen, Shivika Gupta, Thomas Klonisch, Ian M.C. Dixon, Morvarid S. Kavosh, Saeid Ghavami, Sunil G. Rattan   +6 more
openaire   +1 more source

Generalized EEG Slowing Across Phasic REM Sleep, Not Subjective RBD Severity, Predicts Neurodegeneration in Idiopathic RBD

Nature and Science of Sleep, 2022
Si-Yi Gong,1,* Yun Shen,1,* Han-Ying Gu,1 Sheng Zhuang,1 Xiang Fu,1,2 Qiao-Jun Wang,1 Cheng-Jie Mao,1 Hua Hu,1 Yong-Ping Dai,1 Chun-Feng Liu1– 3 1Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated ...
Gong SY, Shen Y, Gu HY, Zhuang S, Fu X, Wang QJ, Mao CJ, Hu H, Dai YP, Liu CF   +9 more
doaj  

Progress on biomarkers of idiopathic rapid eye movement sleep behavior disorder conversion to neurodegenerative diseases

Chinese Journal of Contemporary Neurology and Neurosurgery, 2023
Idiopathic rapid eye movement sleep behavior disorde (iRBD) is a precursor symptom of neurodegenerative diseases, and most patients will convert to neurodegenerative diseases later in the disease. Reliable biological markers are of great significance for
ZHANG Xuan, XUE Rong
doaj   +1 more source

Functional Connectivity Associations With Markers of Disease Progression in GRN Pathogenic Variant Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autosomal dominant progranulin (GRN) pathogenic variants are a genetic cause of frontotemporal lobar degeneration. Though clinical trials for GRN‐related therapies are underway, there is an unmet need for biomarkers that can predict symptom onset and track disease progression.
Taru M. Flagan, Stephanie A. Chu, Suvi Häkkinen, Liwen Zhang, David McFall, Jonathan D. Rohrer, Jesse A. Brown, Alex J. Lee, Kristen Fernhoff, Lorenzo Pasquini, Katherine P. Rankin, Maria Luisa Mandelli, Maria Luisa Gorno‐Tempini, Jennifer S. Yokoyama, Virginia E. Sturm, Brian Appleby, Bradford C. Dickerson, Kimiko Domoto‐Reilly, Tatiana Foroud, Daniel H. Geschwind, Nupur Ghoshal, Neill R. Graff‐Radford, Ging‐Yuek Robin Hsiung, Eric J. Huang, Edward Huey, Kejal Kantarci, Irene Litvan, Ian R. Mackenzie, Mario F. Mendez, Chiadi U. Onyike, Leonard Petrucelli, Eliana Marisa Ramos, Erik D. Roberson, Julio C. Rojas, Maria Carmela Tartaglia, Arthur W. Toga, Sandra Weintraub, Leah K. Forsberg, Hilary W. Heuer, Brad F. Boeve, Adam L. Boxer, Howard J. Rosen, Bruce L. Miller, Fermin Moreno, William W. Seeley, Suzee E. Lee, on behalf of the ALLFTD Consortium   +46 more
wiley   +1 more source

Autonomic dysfunction and phenoconversion in idiopathic REM sleep behavior disorder

Clinical Autonomic Research, 2020
REM sleep behavior disorder (RBD) is a common finding among patients with synucleinopathies. We aimed to determine the degree of autonomic dysfunction in patients presenting with idiopathic RBD (iRBD), and the predictive value of autonomic dysfunction for phenoconversion to a defined neurodegenerative disease.We searched our electronic medical record ...
Erik K. St. Louis, Phillip A. Low, Wolfgang Singer, Tonette L. Gehrking, Bradley F. Boeve, Mariana D. Suarez, Michael H. Silber, Stuart J. McCarter   +7 more
openaire   +4 more sources

Genetic Modifiers of Parkinson's Disease: A Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the associations of LRRK2 p.G2019S, GBA1 p.N409S, polygenic risk scores (PRS), and APOE E4 on PD penetrance, risk, and symptoms. Methods We conducted a US‐based observational case–control study using data from the 23andMe Inc. and Fox Insight Genetic Substudy (FIGS) databases.
Matthew J. Kmiecik, Michael V. Holmes, Pierre Fontanillas, Giulietta M. Riboldi, Ruth B. Schneider, Jingchunzi Shi, Anna Guan, Susana Tat, Steven Micheletti, Keaton Stagaman, Josh Gottesman, David A. Hinds, Joyce Y. Tung, 23andMe Research Team, Stella Aslibekyan, Lucy Norcliffe‐Kaufmann   +15 more
wiley   +1 more source