Results 51 to 60 of about 3,784 (223)

Case report: Therapeutic drug monitoring and CYP2D6 phenoconversion in a protracted paroxetine intoxication

Frontiers in Pharmacology
ObjectiveThe cytochrome P450 2D6 (CYP2D6) is an enzyme involved in the oxidative biotransformation of various widely used drugs, including paroxetine, a substrate and strong inhibitor of the enzyme.
Alena Damborská, Alena Damborská, Lenka Hanáková, Eva Pindurová, Eva Pindurová, Kateřina Horská, Kateřina Horská   +6 more
doaj   +2 more sources

Clinical characteristics and phenoconversion in isolated REM sleep behavior disorder: a prospective single-center study in Korea, compared with Montreal cohort. [PDF]

J Clin Sleep Med
Isolated rapid eye movement sleep behavior disorder is a prodromal synucleinopathy, but its conversion rate and subtypes can vary among different cohorts. We report the clinical characteristics and phenoconversion rate of the large single-center isolated
Byun JI, Sunwoo JS, Shin YW, Shin JW, Kim TJ, Jun JS, Shin JH, Kim HJ, Montplaisir J, Gagnon JF, Pelletier A, Delva A, Postuma RB, Jung KY.   +13 more
europepmc   +2 more sources

Gait Analysis with Wearable Sensors in Isolated REM Sleep Behavior Disorder Associated with Phenoconversion: An Explorative Study

Journal of Parkinson's Disease
Background: Gait disturbance is a vital characteristic of motor manifestation in α– synucleinopathies, especially Parkinson’s disease. Subtle gait alterations are present in isolated rapid eye movement sleep behavior disorder (iRBD) patients before ...
Shanshan Cen, Hui Zhang, Yuan Li, Z. Gu, Yuan Yuan, Zheng Ruan, Yanning Cai, J. K. Chhetri, Shuying Liu, W. Mao, Piu Chan   +10 more
semanticscholar   +3 more sources

Impact of Depression on Cognitive Function and Phenoconversion to Neurodegenerative Diseases in Patients With Isolated REM Sleep Behavior Disorder [PDF]

Acta Neurologica Scandinavica
Background: This study was aimed at analyzing cognitive function and quantitative electroencephalogram (qEEG) in patients with isolated REM sleep behavior disorder (iRBD) based on the presence of depression and at evaluating the impact of depression on ...
Seock Hyeon Moon, J. Hong, Minji Lee, Hak Hyeon Kim, In-Young Yoon   +4 more
semanticscholar   +2 more sources

Derivation and Validation of a Phenoconversion-Related Pattern in Idiopathic Rapid Eye Movement Behavior Disorder [PDF]

, 2023
Morbelli, S.
core   +3 more sources

Visuospatial dysfunction predicts dementia-first phenoconversion in isolated REM sleep behaviour disorder

Journal of Neurology Neurosurgery & Psychiatry
Objective While isolated rapid eye movement sleep behaviour disorder (iRBD) is known as a prodrome of α-synucleinopathies, the prediction for its future phenoconversion to parkinsonism-first or dementia-first subtype remains a challenge. This study aimed
Jing Wang, Bei Huang, Li Zhou, Shirley Tang, H. Feng, J. Chan, Steven W H Chau, Jihui Zhang, Shirley Xin Li, V. Mok, Y. Wing, Yaping Liu   +11 more
semanticscholar   +3 more sources

Phenoconversion of Cytochrome P450 Metabolism: A Systematic Review [PDF]

Journal of Clinical Medicine, 2020
Phenoconversion is the mismatch between the individual’s genotype-based prediction of drug metabolism and the true capacity to metabolize drugs due to nongenetic factors. While the concept of phenoconversion has been described in narrative reviews, no systematic review is available.
Sylvia D. Klomp, Martijn L. Manson, Henk-Jan Guchelaar, Jesse J. Swen   +3 more
openaire   +5 more sources

Basal Forebrain Volume Predicts Disease Conversion in Prodromal Synucleinopathy. [PDF]

Mov Disord Clin Pract
Abstract Background Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal stage of Parkinson's disease (PD) and dementia with Lewy bodies (DLB). The basal forebrain (BF), a key cholinergic structure, is a site of known pathology in later stages of Lewy body disorders.
Churchill L, Konuri A, Ignatavicius A, Anderson J, Lewis SJG, Matar E.   +5 more
europepmc   +2 more sources

The Relevance of Integrating CYP2C19 Phenoconversion Effects into Clinical Pharmacogenetics [PDF]

Pharmacopsychiatry
Abstract Introduction CYP2D6 and CYP2C19 functional status as defined by genotype is modulated by phenoconversion (PC) due to pharmacokinetic interactions. As of today, there is no data on the effect size of PC for CYP2C19 functional status.
Maike Scherf‐Clavel, Heike Weber, Stefan Unterecker, Amelie Frantz, Andreas Eckert, Andreas Reif, Jürgen Deckert, Martina Hahn   +7 more
openalex   +3 more sources

"Phenoconversion in adult patients with b-thalassemia" [PDF]

Patients with clinically significant forms of β-thalassemia have been historically classified as having a β-thalassemia major or β-thalassemia intermedia phenotype, with the first primarily referring to patients who present with severe anemia during ...
Barella S, Culcasi M, De Franceschi L, Ferrero GBm Lisi R, Forni G, Gianesin B, Long F, Musallam KM, Origa R, Pasanisi A, Pinto V, Roberti D, Sciortino R   +12 more
core   +2 more sources