Results 61 to 70 of about 1,759 (167)

The role of club cell phenoconversion and migration in idiopathic pulmonary fibrosis

Aging, 2016
Idiopathic pulmonary fibrosis (IPF) is an age-related multifactorial disease featuring non-uniform lung fibrosis. The decisive cellular events at early stages of IPF are poorly understood. While the involvement of club cells in IPF pathogenesis is unclear, their migration has been associated with lung fibrosis.
Travis Herrin, Ruan Cox, Narasaiah Kolliputi, Joseph Leung, Yashwant Pathak, Venkata Ramireddy Narala, Venkata Ramireddy Narala, Lakshmi Galam, Ramani Soundararajan, Nima Hosseinian, Mason Breitzig, Jayanthraj Gone, Andrew J. Cooke, Alexander Czachor, Lee C. Tan, Jutaro Fukumoto, Sanjay Mahendrasah, Young Ae Cho, Priyanshi Patel, Neha Muthavarapu, Richard F. Lockey   +20 more
openaire   +4 more sources

P2587Cardiosomal microRNAs are essential in post-infarction myofibroblast phenoconversion [PDF]

European Heart Journal, 2019
Abstract Background Circulating microRNAs (miRNAs) are actively transported, via inclusion in extracellular microvesicles/exosomes (herein named cardiosomes since they are deriving from cardiomyocytes), allowing protection from degradation and underlying cell-cell communications ...
Jun Shu, G Santulli, C Sardu, A Matarese
openaire   +1 more source

Longitudinal evolution of cortical thickness signature reflecting Lewy body dementia in isolated REM sleep behavior disorder: a prospective cohort study

Translational Neurodegeneration, 2023
Background The isolated rapid-eye-movement sleep behavior disorder (iRBD) is a prodromal condition of Lewy body disease including Parkinson's disease and dementia with Lewy bodies (DLB).
Jung Hwan Shin, Heejung Kim, Yu Kyeong Kim, Eun Jin Yoon, Hyunwoo Nam, Beomseok Jeon, Jee-Young Lee   +6 more
doaj   +1 more source

Nerve Excitability in Asymptomatic Carriers and Amyotrophic Lateral Sclerosis Patients With C9orf72

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We investigated the effects of C9orf72 mutation carriership on peripheral nerve excitability in asymptomatic individuals from families with a history of C9orf72 amyotrophic lateral sclerosis (ALS) and patients. Methods We included 47 asymptomatic individuals from families with a history of C9orf72 ALS, of whom 23 were carriers (C9 ...
Diederik J. L. Stikvoort García, H. Stephan Goedee, Leonard H. van den Berg, Boudewijn T. H. M. Sleutjes   +3 more
wiley   +1 more source

Bacterial challenge-associated metabolic phenotypes in Hermetia illucens defining nutritional and functional benefits

Scientific Reports, 2021
Black soldier fly (BSF, Hermetia illucens) is popular for its applications in animal feed, waste management and antimicrobial peptide source. The major advantages of BSF larva include their robust immune system and high nutritional content that can be ...
Phuc N. Ho, Poramate Klanrit, Yupa Hanboonsong, Umaporn Yordpratum, Manida Suksawat, Thanaporn Kulthawatsiri, Anyarin Jirahiranpat, Suthicha Deewai, Panya Mackawan, Rasana W. Sermswan, Nisana Namwat, Watcharin Loilome, Tueanjit Khampitak, Arporn Wangwiwatsin, Jutarop Phetcharaburanin   +14 more
doaj   +1 more source

Cytochrome P450 2D6 *17 and *29 Allele Activity for Risperidone Metabolism: Advancing Precision Medicine Health Equity

Clinical Pharmacology &Therapeutics, EarlyView.
CYP2D6 alleles with low frequency in Eurocentrically biased study populations are often excluded from pharmacogenetic investigation and consequently may have misassigned activity values. This health inequity may be contributing to imprecise dose predictions for CYP2D6‐metabolizing drugs.
Oyinlade Kehinde, Samuel E. Vaughn, Ogochukwu Amaeze, Paul Toren, Brandon Retke, Akinyemi Oni‐Orisan, Laura B. Ramsey   +6 more
wiley   +1 more source

Relationship of Mediterranean Diet and Caloric Intake to Phenoconversion in Huntington Disease [PDF]

JAMA Neurology, 2013
Adherence to Mediterranean-type diet (MeDi) may delay onset of Alzheimer and Parkinson diseases. Whether adherence to MeDi affects time to phenoconversion in Huntington disease (HD), a highly penetrant, single-gene disorder, is unknown.To determine if MeDi modifies the time to clinical onset of HD (phenoconversion) in premanifest carriers participating
Shirley Eberly, Karen Marder, Karen Marder, Caroline M. Tanner, Ira Shoulson, David Oakes, Nikolaos Scarmeas, Nikolaos Scarmeas, Nikolaos Scarmeas, Yian Gu   +9 more
openaire   +5 more sources

Clinical Pharmacogenetics Implementation Consortium Guideline for NAT2 Genotype and Hydralazine Therapy

Clinical Pharmacology &Therapeutics, EarlyView.
Hydralazine is a vasodilator typically used in the treatment of resistant hypertension and heart failure. N‐acetyltransferase 2 (NAT2) catalyzes the metabolism of hydralazine into inactive metabolites. NAT2 poor metabolizers (historically referred to as “slow acetylators”) are predicted to have increased plasma hydralazine concentrations compared with ...
Michael T. Eadon, David W. Hein, Michael A. Andersen, Arlene B. Chapman, Rhonda M. Cooper‐DeHoff, Zeruesenay Desta, Julio D. Duarte, Amanda L. Elchynski, Andrea Gaedigk, Seth E. Karol, Nita A. Limdi, Christelle Lteif, Laura Sosinski, Pablo Zubiaur, Michelle Whirl‐Carrillo, Teri E. Klein, Kelly E. Caudle, Roseann S. Donnelly, José A.G. Agúndez   +18 more
wiley   +1 more source

Clinical Implementation of Pharmacogenomics and Drug–Drug Interaction Screening in a German Academic Teaching Hospital and Outpatient Follow‐Up

Clinical Pharmacology &Therapeutics, EarlyView.
Overview of the implemented pharmacogenomics (PGx) process in clinical routine at the Robert Bosch Hospital: from patient enrollment via the hospital information system, DNA detection using a customized TaqMan OpenArray panel and qPCR for CNV assessment, to clinical translation of genotyping results into PGx guideline‐based recommendations using a ...
Roman Tremmel, Filippa Schreeck, Simon Jaeger, Severin Schricker, Elke Schaeffeler, Svitlana Igel, Daniela Steinberger, Manuel Pagitz, Jörg Latus, Markus Ketteler, Kerstin Bühl, Marc‐H. Dahlke, Hans‐Georg Kopp, Matthias Schwab   +13 more
wiley   +1 more source

Transforming Pharmacovigilance With Pharmacogenomics: Toward Personalized Risk Management

Clinical Pharmacology &Therapeutics, EarlyView.
Pharmacovigilance is a critical component of medication safety. Despite rigorous evaluation of new drugs during clinical trials, some adverse effects might only be identified once pharmaceuticals are used by a larger population for a longer duration.
Claire Spahn, Nanase Toda, Blaine Groat, Omar Aimer, Sara Rogers, Akinyemi Oni‐Orisan, Andrew Monte, Nancy Hakooz, on behalf of the Pharmacogenomics Global Research Network (PGRN) Publications Committee   +8 more
wiley   +1 more source