Results 81 to 90 of about 1,759 (167)

CXCL12/CXCR4-Mediated Procollagen Secretion Is Coupled To Cullin-RING Ubiquitin Ligase Activation

Scientific Reports, 2018
Tissue fibrosis is mediated by the actions of multiple pro-fibrotic proteins that can induce myofibroblast phenoconversion through diverse signaling pathways coupled predominantly to Smads or MEK/Erk proteins.
Susan Patalano, José Rodríguez-Nieves, Cory Colaneri, Justin Cotellessa, Diego Almanza, Alisa Zhilin-Roth, Todd Riley, Jill Macoska   +7 more
doaj   +1 more source

Ikelos‐Rating Scale: Validation of a Behavioural Severity Marker in REM Sleep Behaviour Disorder

Journal of Sleep Research, EarlyView.
ABSTRACT The Ikelos‐Rating Scale (Ikelos‐RS) is a new, expert‐interviewed and bedpartner‐reported severity marker assessing frequency and expression of isolated REM sleep behaviour disorder (iRBD), a precursor of clinical α‐synucleinopathies. This study aimed to validate the Ikelos‐RS in 180 patients with three‐night PSG‐confirmed iRBD (68.4 ± 8.3 ...
Sophia Stotz, Frederik Bes, Dieter Kunz
wiley   +1 more source

Accuracy of Rating Scales and Clinical Measures for Screening of Rapid Eye Movement Sleep Behavior Disorder and for Predicting Conversion to Parkinson’s Disease and Other Synucleinopathies

Frontiers in Neurology, 2018
Rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by repeated episodes of REM sleep-related vocalizations and/or complex motor behaviors.
Matej Skorvanek, Matej Skorvanek, Eva Feketeova, Eva Feketeova, Monica M. Kurtis, Jan Rusz, Jan Rusz, Karel Sonka   +7 more
doaj   +1 more source

Validation of RBDtector: An Open‐Source Automated Software for Scoring REM Sleep Without Atonia

Journal of Sleep Research, EarlyView.
ABSTRACT Accurate quantification of REM sleep without atonia (RSWA) is essential in the diagnosis of idiopathic/isolated REM sleep behaviour disorder (iRBD). This study aims to validate RBDtector, a free and open‐source tool for automated RSWA quantification using the Sleep Innsbruck Barcelona (SINBAR) scoring method, by comparing its performance ...
Stephen Joza, Amélie Pelletier, Jean‐François Gagnon, Jacques Y. Montplaisir, David Bertram, Kasia Bozek, Ronald B. Postuma, Michael Sommerauer   +7 more
wiley   +1 more source

White matter hyperintensities precede other biomarkers in GRN frontotemporal dementia

Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract INTRODUCTION Increased white matter hyperintensities (WMHs) have been reported in genetic frontotemporal dementia (FTD) in small studies, but the sequence of WMH abnormalities relative to other biomarkers is unclear. METHODS Using a large dataset (n = 763 GENFI2 participants), we measured WMHs and examined them across genetic FTD variants and ...
Mahdie Soltaninejad, Mahsa Dadar, D. Louis Collins, Reza Rajabli, Vikram Venkatraghavan, Arabella Bouzigues, Lucy L. Russell, Phoebe H. Foster, Eve Ferry‐Bolder, John C. van Swieten, Lize C. Jiskoot, Harro Seelaar, Raquel Sanchez‐Valle, Robert Laforce, Caroline Graff, Daniela Galimberti, Rik Vandenberghe, Alexandre de Mendonça, Pietro Tiraboschi, Isabel Santana, Alexander Gerhard, Johannes Levin, Benedetta Nacmias, Markus Otto, Maxime Bertoux, Thibaud Lebouvier, Chris R. Butler, Isabelle Le Ber, Elizabeth Finger, Maria Carmela Tartaglia, Mario Masellis, James B. Rowe, Matthis Synofzik, Fermin Moreno, Barbara Borroni, Jonathan D. Rohrer, Yasser Iturria‐Medina, Simon Ducharme, GENFI Consortium   +38 more
wiley   +1 more source

Alzheimer's disease diagnostic progression is associated with cerebrovascular disease and neuroinflammation in adults with Down syndrome

Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract INTRODUCTION Despite having few vascular risk factors, people with Down syndrome (DS) have MRI evidence of cerebrovascular disease (CVD) and neuroinflammation that worsens with Alzheimer's disease (AD) severity. We investigated whether markers of CVD and inflammation are associated with AD‐related diagnostic progression in people with DS ...
Natalie C. Edwards, Patrick J. Lao, Mohamad J. Alshikho, Olivia M. Ericsson, Batool Rizvi, Melissa E. Petersen, Sid O'Bryant, Lisi Flores‐Aguilar, Sabrina Simoes, Mark Mapstone, Dana L. Tudorascu, Shorena Janelidze, Oskar Hansson, Benjamin L. Handen, Bradley T. Christian, Joseph H. Lee, Florence Lai, H Diana Rosas, Shahid Zaman, Ira T. Lott, Michael A. Yassa, Alzheimer's Biomarkers Consortium–Down Syndrome (ABC‐DS) Investigators, José Gutierrez, Donna M. Wilcock, Elizabeth Head, Adam M. Brickman   +25 more
wiley   +1 more source

Rapid eye movement sleep behavior disorder: modern concept and Parkinson’s disease correlation [PDF]

Анналы клинической и экспериментальной неврологии
This review describes the association between rapid eye movement (REM) sleep behavior disorder (RBD) and synucleinopathies, primarily Parkinson's disease.
Diana M. Khasanova, Zuleykha A. Zalyalova, Guzal R. Ilina, Nailya I. Bagdanova   +3 more
doaj   +1 more source

Longitudinal Trajectory of Multimodal Markers in a Patient with Isolated REM Sleep Behavior Disorder

Movement Disorders, EarlyView.
Seohee Choi, Ryul Kim, Kyung Ah Woo, Jung Hwan Shin, Eun Jin Yoon, Heejung Kim, Yu Kyeong Kim, Jee‐Young Lee   +7 more
wiley   +1 more source

Bowel movement frequency and difficult defecation using constipation assessment scale in patients with isolated REM sleep behavior disorder

Clinical Parkinsonism & Related Disorders
Introduction: This study evaluated constipation, including reduced bowel movement frequency and difficult defecation, in patients with isolated rapid eye movement sleep behavior disorder (IRBD), which is prodromal Parkinson’s disease (PD) or dementia ...
Tomoyuki Miyamoto, Itsuo Nakajima, Takuo Arikawa, Masayuki Miyamoto   +3 more
doaj   +1 more source

Plasma 24-metabolite panel predicts preclinical transition to clinical stages of Alzheimer’s disease

Frontiers in Neurology, 2015
We recently documented plasma lipid dysregulation in preclinical late-onset Alzheimer’s disease (LOAD). A ten plasma lipid panel, predicted phenoconversion and provided 90% sensitivity and 85% specificity in differentiating an at-risk group from those ...
Massimo S Fiandaca, Xioagang eZhong, Amrita K Cheema, Michael H. Orquiza, Swathi eChidambaram, Ming T Tan, Carole Roan Gresenz, Kevin T FitzGerald, Michael A Nalls, Andrew B Singleton, Mark eMapstone, Howard J Federoff   +11 more
doaj   +1 more source