Results 51 to 60 of about 85,574 (269)

Phytochemical, Antibacterial and Antioxidant Activity Evaluation of Rhodiola crenulata

Molecules, 2020
The chemical components, as well as the antibacterial and antioxidant activities of the essential oil (EO) and crude extracts prepared from Rhodiola crenulata were investigated. The essential oil was separated by hydrodistillation, and gas chromatography-
Lingyun Zhong, Lianxin Peng, Jia Fu, Liang Zou, Gang Zhao, Jianglin Zhao   +5 more
doaj   +1 more source

Subcritical water extraction of polyphenols from endemic Algerian plants with medicinal properties [PDF]

Acta Periodica Technologica, 2020
Ephedra alata, Ononis angustissima, and Genista saharae are endemic Algerian plants with pharmacological potential, used for centuries in traditional medicine. Herein the efficiency of subcritical water extraction (SWE) of phenols and flavonoids
Benmerzoug Abdelmoumen, Švarc-Gajić Jaroslava, Nastić Nataša, Guettaf Sofiane, Harzallah Daoud   +4 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Winemaking Byproducts as Source of Antioxidant Components: Consumers’ Acceptance and Expectations of Phenol-Enriched Plant-Based Food

Antioxidants, 2020
One of the food industry’s priorities is to recover byproducts and move towards more sustainable systems. Among wine-chain byproducts, unripe grapes represent a promising source of antioxidants. However, the development of new foods enriched using phenol-
Cristina Proserpio, Giovanna Fia, Ginevra Bucalossi, Bruno Zanoni, Sara Spinelli, Caterina Dinnella, Erminio Monteleone, Ella Pagliarini   +7 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Nanocomposites Photocatalysis Application for the Purification of Phenols and Real Olive Mill Wastewater through a Sequential Process

Applied Sciences, 2020
In this study, a synthetic phenol solution of water and raw olive mill wastewater (OMW) were considered to achieve purification of the aqueous streams from pollutants.
Srikanth Vuppala, Marco Stoller
doaj   +1 more source

Various techniques for phenolic removal from olive mill wastewater

Croatian Journal of Food Science and Technology, 2021
As the world's population increases, so does the amount of wastewater generated during agricultural activities. Inadequate wastewater management can be the cause of sea and river pollution.
Melita Lončarić, Mirna Habuda-Stanić, Maja Molnar   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Anti-Microbial, Anti-Oxidant, and α-Amylase Inhibitory Activity of Traditionally-Used Medicinal Herbs: A Comparative Analyses of Pharmacology, and Phytoconstituents of Regional Halophytic Plants’ Diaspora

Molecules, 2020
Halophytes are the category of plants growing under harsh conditions of super-salinity, and are wide-spread in the coastal Mediterranean climatic conditions and desert oasis.
Mohsen S. Al-Omar, Hamdoon A. Mohammed, Salman A. A. Mohammed, Essam Abd-Elmoniem, Yasser I. Kandil, Hussein M. Eldeeb, Sridevi Chigurupati, Ghassan M. Sulaiman, Hadeel K. Al-Khurayyif, Basma S. Almansour, Prarthana M. Suryavamshi, Riaz A. Khan   +11 more
doaj   +1 more source