Results 31 to 40 of about 41,824,283 (165)

Revealing polygenic pleiotropy using genetic risk scores for asthma

HGG Advances, 2023
Summary: In this study we examined how genetic risk for asthma associates with different features of the disease and with other medical conditions and traits.
Matthew Dapas, Yu Lin Lee, William Wentworth-Sheilds, Hae Kyung Im, Carole Ober, Nathan Schoettler   +5 more
doaj   +1 more source

Phenome-wide analysis of Taiwan Biobank reveals novel glycemia-related loci and genetic risks for diabetes

Communications Biology, 2022
A phenome-wide association study and polygenic risk score analysis identifies several loci linked to metabolic disease and type 2 diabetes in the Taiwanese population.
Chia-Jung Lee, Ting-Huei Chen, Aylwin Ming Wee Lim, Chien-Ching Chang, Jia-Jyun Sie, Pei-Lung Chen, Su-Wei Chang, Shang-Jung Wu, Chia-Lin Hsu, Ai-Ru Hsieh, Wei-Shiung Yang, Cathy S. J. Fann   +11 more
doaj   +1 more source

An integrative functional genomics framework for effective identification of novel regulatory variants in genome–phenome studies

Genome Medicine, 2018
Background Genome–phenome studies have identified thousands of variants that are statistically associated with disease or traits; however, their functional roles are largely unclear.
Junfei Zhao, Feixiong Cheng, Peilin Jia, Nancy Cox, Joshua C. Denny, Zhongming Zhao   +5 more
doaj   +1 more source

Genetically Determined Chronic Low-Grade Inflammation and Hundreds of Health Outcomes in the UK Biobank and the FinnGen Population: A Phenome-Wide Mendelian Randomization Study

Frontiers in Immunology, 2021
BackgroundC-reactive protein (CRP) has been used as a biomarker of chronic low-grade inflammation in observational studies. We aimed to determine whether genetically determined CRP was associated with hundreds of human phenotypes to guide anti ...
Shucheng Si, Shucheng Si, Shucheng Si, Jiqing Li, Jiqing Li, Jiqing Li, Marlvin Anemey Tewara, Fuzhong Xue, Fuzhong Xue, Fuzhong Xue   +9 more
doaj   +1 more source

A phenome-wide association study of genetically determined nicotine metabolism reveals novel links with health-related outcomes. [PDF]

Eur J Epidemiol
Faster nicotine metabolism, defined as the nicotine metabolite ratio (NMR), is known to associate with heavier smoking and challenges in smoking cessation.
Buchwald J, Lehtimäki T, Raitakari O, Salomaa V, Kaprio J, Pirinen M.   +5 more
europepmc   +2 more sources

Phenome-wide significant phenotypes in MGI identified using various PRS construction strategies^a.

, 2019
Phenome-wide significant phenotypes in MGI identified using various PRS construction strategiesa.
Stephanie E. Moser (6836720), Bhramar Mukherjee (90346), Peter VandeHaar (6836696), Sarah A. Gagliano Taliun (6836708), Jonathon LeFaive (6836711), Thomas T. Klumpner (6836717), Erin O. Kaleba (6836714), Sachin Kheterpal (5538692), Robert B. Peng (6836699), Sayantan Das (1734532), Lauren J. Beesley (6836693), Stephen B. Gruber (108155), Maxwell Salvatore (6836702), Matthew Zawistowski (6836705), Lars G. Fritsche (162272), Victoria M. Blanc (6836723), Chad M. Brummett (6338336), Gonçalo R. Abecasis (36598)   +17 more
core   +1 more source

Phenome-Wide Association Study to Explore Relationships between Immune System Related Genetic Loci and Complex Traits and Diseases. [PDF]

, 2016
We performed a Phenome-Wide Association Study (PheWAS) to identify interrelationships between the immune system genetic architecture and a wide array of phenotypes from two de-identified electronic health record (EHR) biorepositories.
Gerhard, Glenn S., Yuki Bradford (496693), Marylyn D. Ritchie (201209), James E. Crowe Jr (151303), Verma, Anurag, James E Crowe, Anna O Basile, Marylyn D Ritchie, Bradford, Yuki, Pendergrass, Sarah A., Crowe, James E., Glenn S Gerhard, David Carey (2936301), Yuki Bradford, Carey, David, Glenn S. Gerhard (259020), Anurag Verma, Sarah A. Pendergrass (87900), Tromp, Gerard, Helena Kuivaniemi (496630), Basile, Anna O., Kuivaniemi, Helena, Ritchie, Marylyn D., Helena Kuivaniemi, Anna O. Basile (2936304), Gerard Tromp, Anurag Verma (669308), Sarah A Pendergrass, David Carey, Gerard Tromp (63007)   +29 more
core   +2 more sources

Association of Interleukin 6 Receptor Variant With Cardiovascular Disease Effects of Interleukin 6 Receptor Blocking Therapy A Phenome-Wide Association Study

, 2018
This phenome-wide association study assesses clinical associations between interleukin 6 receptor ( IL6R ) single-nucleotide polyporphisms and known IL6R drug effects and whether large biobanks and genetics can be used to assess potential beneficial and ...
Huang, Jie, Sun, Jiehuan, Honerlaw, Jacqueline, Damrauer, Scott, Cai, Tianrun A, O’Donnell, Christopher J, Ho, Yuk-Lam, Hong, Chuan, Gagnon, David, Tsao, Philip, Link, Nicholas, Cho, Kelly, Schubert, Petra, Zhang, Yichi, Cai, Tianxi, Ahuja, Yuri, Sun, Yan V, Costa, Lauren, Wilson, Peter, Gaziano, J. Michael, Liao, Katherine P   +20 more
core   +1 more source

Phenome-wide analysis of genome-wide polygenic scores [PDF]

, 2015
Genome-wide polygenic scores (GPS), which aggregate the effects of thousands of DNA variants from genome-wide association studies (GWAS), have the potential to make genetic predictions for individuals.
Dale, P. S., Krapohl, E., Zabaneh, D, O'Reilly, P F, G Breen, Dale, P S, S von Stumm, Dale, Philip, K Rimfeld, Rimfeld, K., O'Reilly, P. F., Breen, G, Euesden, J, J Euesden, P F O'Reilly, Euesden, J., Pingault, J. B., Plomin, R., Breen, G., Rimfeld, K, Zabaneh, Magda Delilah; id_orcid, Krapohl, E, Von Stumm, Sophie, J-B Pingault, O'Reilly, Paul Francis, Pingault, Jean-Baptiste, Plomin, R, D Zabaneh, Euesden, Jack, Breen, Gerome Daniel; id_orcid, Pingault, J.-B., P S Dale, Krapohl, Eva Maria Laura, Plomin, Robert Joseph, Pingault, J-B, Von Stumm, S., Rimfeld, Kaili, E Krapohl, R Plomin, Zabaneh, D.   +39 more
core   +1 more source

Supplemental material for Phenome-wide association study identifies dsDNA as a driver of major organ involvement in systemic lupus erythematosus

, 2018
Supplemental Material for Phenome-wide association study identifies dsDNA as a driver of major organ involvement in systemic lupus erythematosus by A. Barnado, R.J. Carroll, C. Casey, L. Wheless, J.C. Denny and L.J.
J.C. Denny (6012626), L.J. Crofford (6012629), R.J. Carroll (6012617), L. Wheless (6012623), A. Barnado (6012614), C. Casey (6012620)   +5 more
core   +1 more source