Results 181 to 190 of about 197,703 (204)

Opportunities for drug repositioning from phenome-wide association studies

Nature Biotechnology, 2015
Majid Rastegar-Mojarad, Zhan Ye, Jill M Kolesar, Scott J Hebbring, Simon M Lin   +4 more
openaire   +4 more sources

Genome-wide association studies and polygenic risk score phenome-wide association studies across complex phenotypes in the human phenotype project.

i Medicina, 2023
BACKGROUND Genome-wide association studies (GWASs) associate phenotypes and genetic variants across a study cohort. GWASs require large-scale cohorts with both phenotype and genetic sequencing data, limiting studied phenotypes.
Zachary Levine, I. Kalka, D. Kolobkov, H. Rossman, A. Godneva, S. Shilo, A. Keshet, Daphna Weissglas-Volkov, T. Shor, A. Diament, Y. Talmor-Barkan, Y. Aviv, Tomer Sharon, A. Weinberger, E. Segal   +14 more
semanticscholar   +1 more source

Genome-Wide Association Study of Intracranial Artery Stenosis Followed by Phenome-Wide Association Study

Translational Stroke Research, 2022
The genetic background of intracranial artery stenosis (ICAS), a major cause of ischemic stroke, remains elusive. We performed the world's first genome-wide association study (GWAS) of ICAS using DNA samples from Japanese subjects, to identify the genetic factors associated with ICAS and their correlation with clinical features.
Shogo Dofuku, Kyuto Sonehara, Satoru Miyawaki, Saori Sakaue, Hideaki Imai, Masahiro Shimizu, Hiroki Hongo, Yuki Shinya, Kenta Ohara, Yu Teranishi, Atsushi Okano, Hideaki Ono, Hirofumi Nakatomi, Akira Teraoka, Kenichi Yamamoto, Yuichi Maeda, Takuro Nii, Toshihiro Kishikawa, Ken Suzuki, Jun Hirata, Meiko Takahashi, Koichi Matsuda, Atsushi Kumanogoh, Fumihiko Matsuda, Yukinori Okada, Nobuhito Saito   +25 more
openaire   +2 more sources

Phenotype-by-phenome-wide association study of treatment resistant depression

2022
AbstractObjectiveTreatment-resistant depression (TRD), defined as inadequate response to at least one or at least two antidepressant (AD) trials, is common in major depressive disorder (MDD). In this study, electronic health records (EHR) were used to identify clinical associations with TRD.MethodsUsing two biobanks, phenomes of patients with at least ...
Brandon J Coombes, Jorge A Sanchez Ruiz, Brian Fennessy, Vanessa Pazdernik, Prakash Adekkanattu, Nicolas A Nunez, Lauren Lepow, Euijung Ryu, Ardesheer Talati, Greg D Jenkins, Richard Pendegraft, Priya Wickramaratne, J John Mann, Mark Olfson, Myrna M Weissman, Jyotishman Pathak, Alexander W Charney, Joanna M Biernacka   +17 more
openaire   +1 more source

N-Lactoyl amino acids: insights from metabolite genome-wide association studies and phenome-wide association analysis

Human Molecular Genetics
N-lactoyl-amino acids (Lac-AA) are emerging as important metabolites with diverse physiological roles. This study integrates metabolomics and genomics to investigate the genetic determinants and clinical relevance of three Lac-AA: N-Lactoyl phenylalanine
Asma A Elashi, Aleem Razzaq, N. Anwardeen, Khaled Naja, Mashael Alshafai, I. Diboun, Omar M. E. Albagha, Mohamed A. Elrayess   +7 more
semanticscholar   +1 more source

Phenome‐wide association study in adult coeliac disease: role of HLA subtype

Alimentary Pharmacology & Therapeutics, 2020
SummaryBackgroundCoeliac disease arises in genetically susceptible individuals, in particular in carriers of HLA‐DQ2/DQ8 risk alleles and is associated with various comorbidities. Coeliac disease may confer an increased mortality, but the data are conflicting.AimsWe aimed to characterize mortality and morbidity in patients with coeliac disease with a ...
Carolin V. Schneider, Moritz Kleinjans, Malin Fromme, Kai Markus Schneider, Pavel Strnad   +4 more
openaire   +2 more sources

Phenome-wide Association Studies on Cardiovascular Health and Fatty Acids Considering PhenotypeQuality Control Practices for Epidemiological Data

Pacific Symposium on Biocomputing, 2019
Phenome-wide association studies (PheWAS) allow agnostic investigation of common genetic variants in relation to a variety of phenotypes but preserving the power of PheWAS requires careful phenotypic quality control (QC) procedures.
Kristin Passero, Xi He, Jiayan Zhou, B. Mueller-Myhsok, M. Kleber, W. Maerz, M. Hall   +6 more
semanticscholar   +1 more source

From Genome-Wide Association Study to Phenome-Wide Association Study: New Paradigms in Obesity Research

2016
Obesity is a condition in which excess body fat has accumulated over an extent that increases the risk of many chronic diseases. The current clinical classification of obesity is based on measurement of body mass index (BMI), waist-hip ratio, and body fat percentage.
Y-P, Zhang, Y-Y, Zhang, D D, Duan
openaire   +2 more sources

EHR-based phenome wide association study in pancreatic cancer.

AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science, 2015
Pancreatic cancer is one of the most common causes of cancer-related deaths in the United States, it is difficult to detect early and typically has a very poor prognosis. We present a novel method of large-scale clinical hypothesis generation based on phenome wide association study performed using Electronic Health Records (EHR) in a pancreatic cancer ...
Tomasz, Adamusiak, Mary, Shimoyama
openaire   +1 more source

Toward a Full Understanding of Causal and Modifiable Risk Factors for Alzheimer's Disease by Integrative Phenome-wide Association Studies.

Biological Psychiatry, 2023
Deng-Feng Zhang, Ming Li
semanticscholar   +1 more source