Results 161 to 170 of about 197,703 (204)

Phenome-wide association studies (PheWAS) across large “real-world data” population cohorts support drug target validation

bioRxiv, 2017
D. Diogo, C. Tian, C. Franklin, Mervi Alanne-Kinnunen, Michael E. March, C. Spencer, Ciara Vangjeli, M. Weale, Hannele Mattsson, Elina Kilpeläinen, P. Sleiman, Dermot F. Reilly, J. McElwee, J. Maranville, Arnaub K Chatterjee, Aman Bhandari, M. Reeve, J. Hutz, N. Bing, Sally John, D. MacArthur, V. Salomaa, S. Ripatti, H. Hakonarson, M. Daly, A. Palotie, D. Hinds, P. Donnelly, C. Fox, A. Day-Williams, R. Plenge, H. Runz   +31 more
semanticscholar   +1 more source

Lp(a) Has Specific Effects on Coronary Artery Disease Independent of LDL-C: A Mendelian Randomization Study. [PDF]

JACC Adv
Lee MP, Koenigsberg SH, Anwar MY, Raffield LM, Lin Z, Ballou AF, Booth JN, Davy-Mendez T, Kassahun H, Kent ST, López JAG, Monda KL, North KE, Yarosh R, Ballantyne CM, Graff M, Avery CL.   +16 more
europepmc   +1 more source

An atlas of exposome-phenome associations in health and disease risk. [PDF]

Nat Med
Patel CJ, Ioannidis JPA, Manrai AK.
europepmc   +1 more source

Moving Mendelian Randomization From Traditional Risk Factors to Molecular Targets for Drug Development and Clinical Trials in Nephrology. [PDF]

Kidney Int Rep
Berube AJ, Yu E, Gaheer PS, Lanktree MB.
europepmc   +1 more source

Genetic insights and mechanistic parallels in gestational diabetes mellitus and type 2 diabetes. [PDF]

Nat Commun
Fu L, Han X, Wang Y, Hu YQ.
europepmc   +1 more source

Friend of GATA2 Variant Ser657Gly Is Associated With Coronary Microvascular Disease. [PDF]

Circ Genom Precis Med
Guerraty MA, Verma SS, Ko YA, McQuillan MA, Conlon DM, Tobias JW, Levin MG, Haury W, Zheng F, Cherlin T, Zhang C, Zhang C, Judy R, Tishkoff SA, Damrauer SM, Arany Z, Rader DJ.   +16 more
europepmc   +1 more source

A phenome-wide hunt for risk factors of Alzheimer's disease: from metabolic clues to neuroimaging evidence. [PDF]

J Transl Med
Liu D, Baranova A, Sun W, Cao H, Zhang B, Zhang F, Alzheimer’s Disease Neuroimaging Initiative, Alzheimer’s Disease Metabolomics Consortium.   +7 more
europepmc   +1 more source

Cardiovascular measures from abdominal MRI provide insights into abdominal vessel genetic architecture. [PDF]

Commun Med (Lond)
Basty N, Sorokin EP, Thanaj M, Whitcher B, Liu Y, Bell JD, Thomas EL, Cule M.   +7 more
europepmc   +1 more source

Evaluation of Potential Therapeutic Targets for Bacterial Infectious Skin Diseases: A Proteome-Wide Mendelian Randomization Study. [PDF]

Clin Cosmet Investig Dermatol
Yan Z, Shi Z, Wang Y, Yin H.
europepmc   +1 more source

Unveiling Novel Traits Associated with Ulcerative Colitis via Phenome-Wide Associations Enhanced by Polygenic Risk Statistics. [PDF]

Genes (Basel)
Wu Y, Liu L, Kars ME, Li R, Li M, Itan Y.   +5 more
europepmc   +1 more source