Results 171 to 180 of about 35,658 (190)
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Unravelling the human genome–phenome relationship using phenome-wide association studies
Nature Reviews Genetics, 2016Advances in genotyping technology have, over the past decade, enabled the focused search for common genetic variation associated with human diseases and traits. With the recently increased availability of detailed phenotypic data from electronic health records and epidemiological studies, the impact of one or more genetic variants on the phenome is ...
William S, Bush +2 more
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Opportunities for drug repositioning from phenome-wide association studies
Nature Biotechnology, 2015Majid Rastegar-Mojarad +4 more
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Translational Stroke Research, 2022
The genetic background of intracranial artery stenosis (ICAS), a major cause of ischemic stroke, remains elusive. We performed the world's first genome-wide association study (GWAS) of ICAS using DNA samples from Japanese subjects, to identify the genetic factors associated with ICAS and their correlation with clinical features.
Shogo Dofuku +25 more
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The genetic background of intracranial artery stenosis (ICAS), a major cause of ischemic stroke, remains elusive. We performed the world's first genome-wide association study (GWAS) of ICAS using DNA samples from Japanese subjects, to identify the genetic factors associated with ICAS and their correlation with clinical features.
Shogo Dofuku +25 more
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Are phenome-wide association studies feasible in a developing country?
Trends in Genetics, 2022Phenome-wide association studies (PheWASs), a powerful approach that examines phenotypes associated with a genetic marker, have been used extensively in highly developed countries. Although there may be a clear need for PheWAS in a developing country such as the Philippines, limitations related to resources and practicality would make conducting them a
Gerard G, Dumancas +14 more
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Phenotype-by-phenome-wide association study of treatment resistant depression
2022AbstractObjectiveTreatment-resistant depression (TRD), defined as inadequate response to at least one or at least two antidepressant (AD) trials, is common in major depressive disorder (MDD). In this study, electronic health records (EHR) were used to identify clinical associations with TRD.MethodsUsing two biobanks, phenomes of patients with at least ...
Brandon J Coombes +17 more
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Phenome‐wide association study in adult coeliac disease: role of HLA subtype
Alimentary Pharmacology & Therapeutics, 2020SummaryBackgroundCoeliac disease arises in genetically susceptible individuals, in particular in carriers of HLA‐DQ2/DQ8 risk alleles and is associated with various comorbidities. Coeliac disease may confer an increased mortality, but the data are conflicting.AimsWe aimed to characterize mortality and morbidity in patients with coeliac disease with a ...
Carolin V. Schneider +4 more
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2016
Obesity is a condition in which excess body fat has accumulated over an extent that increases the risk of many chronic diseases. The current clinical classification of obesity is based on measurement of body mass index (BMI), waist-hip ratio, and body fat percentage.
Y-P, Zhang, Y-Y, Zhang, D D, Duan
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Obesity is a condition in which excess body fat has accumulated over an extent that increases the risk of many chronic diseases. The current clinical classification of obesity is based on measurement of body mass index (BMI), waist-hip ratio, and body fat percentage.
Y-P, Zhang, Y-Y, Zhang, D D, Duan
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EHR-based phenome wide association study in pancreatic cancer.
AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science, 2015Pancreatic cancer is one of the most common causes of cancer-related deaths in the United States, it is difficult to detect early and typically has a very poor prognosis. We present a novel method of large-scale clinical hypothesis generation based on phenome wide association study performed using Electronic Health Records (EHR) in a pancreatic cancer ...
Tomasz, Adamusiak, Mary, Shimoyama
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Large-scale association analyses identify host factors influencing human gut microbiome composition
Nature Genetics, 2021Alexander Kurilshchikov +2 more
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