Results 181 to 190 of about 39,899,172 (210)

Maturation and application of phenome-wide association studies

Trends in Genetics, 2022
In the past 10 years since its introduction, phenome-wide association studies (PheWAS) have uncovered novel genotype-phenotype relationships. Along the way, PheWAS have evolved in many aspects as a study design with the expanded availability of large data repositories with genome-wide data linked to detailed phenotypic data.
Dana Crawford
exaly   +3 more sources

Phenome-Wide Association Studies

JAMA - Journal of the American Medical Association, 2022
Josh Denny, Dan Roden, Lisa Bastarache   +2 more
exaly   +4 more sources

Are phenome-wide association studies feasible in a developing country?

Trends in Genetics, 2022
Phenome-wide association studies (PheWASs), a powerful approach that examines phenotypes associated with a genetic marker, have been used extensively in highly developed countries. Although there may be a clear need for PheWAS in a developing country such as the Philippines, limitations related to resources and practicality would make conducting them a
Romulo de Castro
exaly   +3 more sources

The challenges, advantages and future of phenome‐wide association studies

Immunology, 2014
SummaryOver the last decade, significant technological breakthroughs have revolutionized human genomic research in the form of genome‐wide association studies (GWASs). GWASs have identified thousands of statistically significant genetic variants associated with hundreds of human conditions including many with immunological aetiologies (e.g.
Scott Hebbring
exaly   +3 more sources

Phenome-Wide Association Studies as a Tool to Advance Precision Medicine [PDF]

Annual Review of Genomics and Human Genetics, 2016
Beginning in the early 2000s, the accumulation of biospecimens linked to electronic health records (EHRs) made possible genome-phenome studies (i.e., comparative analyses of genetic variants and phenotypes) using only data collected as a by-product of typical health care.
Josh Denny, Dan Roden, Lisa Bastarache   +2 more
exaly   +3 more sources

Phenome-wide association studies between SERINC2 and neuropsychiatric disorders

Frontiers in Psychiatry
ObjectivesSERINC2 has been associated with alcoholism, bipolar disorder and autism, but the comparability and specificity issues of the findings remain unaddressed. The present study aimed to comprehensively analyze various neuropsychiatric disorders pinpoint the most reliable conditions predisposed by SERINC2.MethodsA total of 2,187 imputed SNPs ...

exaly   +4 more sources

Genome-Wide Association Study of Intracranial Artery Stenosis Followed by Phenome-Wide Association Study

Translational Stroke Research, 2022
The genetic background of intracranial artery stenosis (ICAS), a major cause of ischemic stroke, remains elusive. We performed the world's first genome-wide association study (GWAS) of ICAS using DNA samples from Japanese subjects, to identify the genetic factors associated with ICAS and their correlation with clinical features.
Shogo Dofuku, Kyuto Sonehara, Satoru Miyawaki, Saori Sakaue, Hideaki Imai, Masahiro Shimizu, Hiroki Hongo, Yuki Shinya, Kenta Ohara, Yu Teranishi, Atsushi Okano, Hideaki Ono, Hirofumi Nakatomi, Akira Teraoka, Kenichi Yamamoto, Yuichi Maeda, Takuro Nii, Toshihiro Kishikawa, Ken Suzuki, Jun Hirata, Meiko Takahashi, Koichi Matsuda, Atsushi Kumanogoh, Fumihiko Matsuda, Yukinori Okada, Nobuhito Saito   +25 more
openaire   +2 more sources

THE TREND TOWARDS PHENOME-WIDE ASSOCIATION STUDIES (PheWASs) IN COVID-19 RESEARCH [PDF]

SOUTHERN JOURNAL OF SCIENCES, 2022
Background: Coronavirus Disease-2019 (COVID-19) appears in individuals asymptomatically and in various symptomatic forms. Symptomatic diversity can result in diagnosis failures, hospitalization, admission to intensive care, multi-organ failure, and death. The causes and risk factors of the severity of disease symptoms are uncertain.
Atçeken, Nazente, Kozalak, Gül, Ozgul, Rıza Köksal, Syed, Hamzah   +3 more
openaire   +1 more source

Unravelling the human genome–phenome relationship using phenome-wide association studies

Nature Reviews Genetics, 2016
Advances in genotyping technology have, over the past decade, enabled the focused search for common genetic variation associated with human diseases and traits. With the recently increased availability of detailed phenotypic data from electronic health records and epidemiological studies, the impact of one or more genetic variants on the phenome is ...
Dana Crawford, William Bush
exaly   +3 more sources

Phenome-Wide Association Studies: Leveraging Comprehensive Phenotypic and Genotypic Data for Discovery [PDF]

Current Genetic Medicine Reports, 2015
With the large volume of clinical and epidemiological data being collected, increasingly linked to extensive genotypic data, coupled with expanding high-performance computational resources, there are considerable opportunities for comprehensively exploring the networks of connections that exist between the phenome and the genome.
Marylyn D Ritchie
exaly   +3 more sources