Results 91 to 100 of about 5,719,995 (296)

Impact of Phenotypic Correction Method and Missing Phenotypic Data on Genomic Prediction of Maize Hybrids

, 2018
Phenotypic datasets in plant breeding are commonly incomplete due to missing phenotypic information. The best approach for correcting these datasets for a stage-wise genomic prediction (GP) is not unanimous in the scientific community.
Galli, G, Lyra, D. H., Alves, F. C, Bandeira-Sousa, M., Granato, I. S. C., Fritsche-Neto, R   +5 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Proteomic landscape of multidimensional aging phenotypes

Genome Medicine
Proteomic signatures of aging hold promise for advancing our understanding of aging evaluation and guiding targeted therapy. Despite this potential, the proteomic landscape of multidimensional aging phenotypes remains inadequately characterized. We aimed to identify the potential proteomic biomarkers of aging process and decipher their molecular ...
Cao, Zhi, Chen, Han, Min, Jiahao, Xu, Chenjie   +3 more
openaire   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Biological aging partly mediates the association between physical activity and overactive bladder: evidence from NHANES 2007–2020

Clinical Epigenetics
Background Overactive bladder (OAB) impairs quality of life and may increase mortality risk. Physical activity (PA) is a modifiable behavior that could protect against OAB, but the role of biological aging as a potential mechanistic link remains unclear.
Junlong Huang, Pingting Chen, Jiayi Zhuang, Ziqiao Wang, Zheng Liu, Wenshuang Li, Chi Zhang   +6 more
doaj   +1 more source

Biological aging, circulating lipid biomarkers and pancreatic diseases: a prospective cohort study based on the UK Biobank

The Journal of Nutrition, Health and Aging
Background: Biological aging refers to gradual declines in overall physiological function and can raise susceptibility to diseases. However, whether biological age acceleration is associated with pancreatic diseases remains unclear.
Hang Zhang, Junwei Huang, Peiyu Lin, Jiayin Song, Chonghui Hu, Biaojun Lin, Lingdan Le, Shangyou Zheng   +7 more
doaj   +1 more source

The MARK-AGE phenotypic database: Structure and strategy

Mechanisms of Ageing and Development, 2015
In the context of the MARK-AGE study, anthropometric, clinical and social data as well as samples of venous blood, buccal mucosal cells and urine were systematically collected from 3337 volunteers. Information from about 500 standardised questions and about 500 analysed biomarkers needed to be documented per individual.
Moreno-Villanueva, Maria, Kötter, Tobias, Sindlinger, Thilo, Baur, Jennifer, Oehlke, Sebastian, Bürkle, Alexander, Berthold, Michael R.   +6 more
openaire   +3 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Construction and validation of a novel nutrient-based index for risk of aging using an interpretable machine learning framework: results from two population-based studies

Nutrition Journal
Background Population aging is becoming increasingly prominent. Although various dietary factors have been associated with aging in older people, no dietary score specifically related to phenotypic aging has yet been developed.
Rui Qiang Li, Ting Yu Lu, Jiao Wang, Wei Sen Zhang, Jun Du, Ya Li Jin, Jun Tao Kan, Tai Hing Lam, Kar Keung Cheng, Emma Yun-zhi Huang, Lin Xu   +10 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source