Results 131 to 140 of about 5,719,995 (296)
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
PLoS ONEBackgroundBiological age acceleration reflects physiological aging and its link to mortality in HSV-infected adults is unclear.MethodsWe analyzed data from 16,065 HSV-seropositive adults aged 20-59 years from the NHANES 1999-2016 cycles (mean age: 35.4 ±
Jun Wei, Yuefeng Li, Yang Liu
doaj +1 more source
Fatigability: A Prognostic Indicator of Phenotypic Aging [PDF]
The Journals of Gerontology: Series A, 2020 Jennifer A Schrack +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Sedentary behavior accelerates biological aging mediated by body mass index in adults
Scientific ReportsSedentary behavior is widely recognized as a detriment to health. Limited conclusions have been drawn about the relationship between sitting time and biomarkers-measured aging.
Jinhang Che +4 more
doaj +1 more source
Announcing New Larger 1939 Model Pak-Age-Car
, 1930 The advertisement is for a delivery vehicle called the Pak-Age-Car.Image was used in a collage created for Destination Indiana Journey Connersville Automotive ...
Pak-Age-Car Corporation
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A sharing of knowledge and experience (ASKE) [PDF]
, 2003 Age Action Ireland ...
Age Action Ireland
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FEBS Open Bio, EarlyView.Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta +7 more
wiley +1 more source
The role of phenotypic plasticity in the colonization of novel environments [PDF]
, 2013 Biological invasions have been argued to be facilitated by phenotypic plasticity. Although experiments have shown plasticity can be adaptive, our current understanding is limited to comparative studies that measure plasticity between invasive and non ...
NC DOCKS at The University of North Carolina at Greensboro +1 more
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