Results 161 to 170 of about 5,719,995 (296)

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

The association between the planetary health diet index (PHDI) and muscular dystrophies: A mediating role of phenotypic age. [PDF]

Medicine (Baltimore)
Lin X, Huang S, Gong H.
europepmc   +1 more source

Prognostic phenotypic and genotypic factors associated with photodynamic therapy response in patients with age-related macular degeneration

, 2014
Takashi Tsuchihashi,1 Keisuke Mori,1 Kuniko Horie-Inoue,2 Yasushi Okazaki,3 Takuya Awata,4,5 Satoshi Inoue,2 Shin Yoneya1 1Department of Ophthalmology, 2Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine ...
Yoneya S, Tsuchihashi T, Mori K, Okazaki Y, Inoue S, Horie-Inoue K, Awata T   +6 more
core  

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Multiomic clocks to predict phenotypic age in mice. [PDF]

J Gerontol A Biol Sci Med Sci
Vera DL, Griffin PT, Leigh D, Kras J, Ramos E, Bishof I, Butler A, Chwalek K, Vogel DS, Kane AE, Sinclair DA.   +10 more
europepmc   +1 more source

Care in the latter years of life

, 2007
Age Action Ireland / [200?
Age Action Ireland
core  

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

The Association Between Phenotypic Age and Primary Loss of Response to Biologic Agent in Patients with Crohn’s Disease

Journal of Inflammation Research
Xin Chen,1 Jingjing Liu,2,3 Yiping Zhang,2 Yu Wang,2 Xiao Chen,2 Qiufeng Zhao1 1Department of Radiology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, People’s Republic of China; 2Department of ...
Chen X, Liu J, Zhang Y, Wang Y, Chen X, Zhao Q   +5 more
doaj  

The mediating role of insulin resistance in depression driving phenotypic age acceleration. [PDF]

Ann Gen Psychiatry
Zhang L, Yang Q, Yu J, Hu Y.
europepmc   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source