Results 171 to 180 of about 5,719,995 (296)

Phenotypic age acceleration: a novel biomarker associated with increased risk of metabolic dysfunction-associated fatty liver disease. [PDF]

Nutr Metab (Lond)
Xie F, Shen Y, Zhao J, Geng X, Zeng N, Han R, Wang Y, Wang Y, Xu W, Fan J.   +9 more
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Phenotypic age acceleration and all-cause and cardiovascular mortality among U.S. adults at risk for heart failure. [PDF]

Am Heart J Plus
Su H, Liu X.
europepmc   +1 more source

Valuing older people, empowering communities, enriching lives

, 2013
Third Age is a national voluntary organisation working to promote the value of older people in communities throughout Ireland. Third Age also celebrates the third age as a stage in life when older people are encouraged to remain engaged in family and ...
The Third Age
core  

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Associations between phenotypic age and carotid atherosclerosis among the general population: evidence from a multi-stage study. [PDF]

BMC Cardiovasc Disord
Zeng N, Tian T, Zhou Q, Li Y, Geng X, Xie F, Han R, Wang Y, Wang Y, Li Y, Fan J.   +10 more
europepmc   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

The Association Between Phenotypic Age and Primary Loss of Response to Biologic Agent in Patients with Crohn's Disease. [PDF]

J Inflamm Res
Chen X, Liu J, Zhang Y, Wang Y, Chen X, Zhao Q.   +5 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Associations of volatile organic compound exposure with phenotypic age acceleration and the synergistic interaction of dietary micronutrients. [PDF]

J Nutr Health Aging
Zhang H, Tian W, Qi G, Zhou B, Sun Y.
europepmc   +1 more source