Results 121 to 130 of about 5,699,048 (257)

Accelerated Phenotypical Aging in Midlife is Associated With Long-Term Cognitive Decline

Innovation in Aging
Abstract PhenoAge, a multi-system biomarker uses easily-obtained common clinical blood tests and determines whether a person is younger or older on a biological and physiological level than expected by chronological age. Higher PhenoAge is associated with increased risk of disability, age-related morbidities and all-cause mortality ...
Merten, Natascha, Baumann, Mary Ryan, Chappell, Richard, Chen, Yanjun, Clark, Lindsay, Johnson, Sterling, Pankow, James, Walaszek, Art   +7 more
openaire   +1 more source

Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif, Diane Demailly, Gabriella A. Horvàth, Juan Dario Ortigoza Escobar, Nathalie Dorison, Mayté Castro Jiménez, Cécile A. Hubsch, Thomas Wirth, Gun‐Marie Hariz, Sophie Huby, Morgan Dornadic, Zohra Souei, Muhammad Mushhood Ur Rehman, Simone Hemm, Mehdi Boulaymen, Eduardo M. Moraud, Jocelyne Bloch, Xavier Vasques   +17 more
wiley   +1 more source

Numerical studies of photon acceleration in laser wakefields [PDF]

, 2004
This chapter looks at numerical studies of photon acceleration in laser ...
Mendonca, Jose Tito, Trines, Raoul M. G. M., Reitsma, Albert, Bingham, Robert, Norreys, P.A., Murphy, C.D.   +5 more
core   +3 more sources

Associations between anthropometric indices and biological age acceleration in American adults: insights from NHANES 2009–2018 data

Scientific Reports
Population aging has become a global phenomenon with significant implications for public health. Aging accelerates the development of age-related diseases, leading to increased social and economic burdens.
Xinyun Chen, Xia Chen, Fangyu Shi, Wenhui Yu, Chang Gao, Shenju Gou, Ping Fu   +6 more
doaj   +1 more source

Global Rather Than Vertical‐Selective Saccadic Abnormalities in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To test whether vertical saccades are preferentially affected in Progressive Supranuclear Palsy (PSP). Methods PSP patients (n = 24) were compared to age‐matched controls (n = 94) and two degenerative groups (Alzheimer's disease, n = 20; Lewy body disease, n = 50).
Duy Duan Nguyen, Mark Paine, Soohyun Lee, Amir Fazlollahi, Baibin (Ben) Wang, John D. O'Sullivan, Peter J. Nestor   +6 more
wiley   +1 more source

Association between red blood cell folate and accelerated aging in American adults: a cross-sectional study from the national health and nutrition examination survey

Frontiers in Nutrition
ObjectiveThe study aims to explore the relationship between red blood cell (RBC) folate concentrations and accelerated aging.MethodsData were derived from the National Health and Nutrition Examination Survey (NHANES) cycles of 2007–2010, including 8,944 ...
Jia-ni Wang, Zhen Song, Cheng Xu, Chong-chao Li   +3 more
doaj   +1 more source

Accelerated Phenotypical Aging in Midlife is Associated with Long‐Term Cognitive Decline in Middle‐Aged Adults

Alzheimer's & Dementia
Abstract Background PhenoAge is a multi‐system blood‐based aging marker that uses common clinical tests of glucose metabolism, inflammation and kidney and liver function. This easily‐obtained marker determines whether a person is younger or older on a biological and physiological level than ...
Merten, Natascha, Baumann, Mary Ryan, Paulsen, Adam J, Li, Huan, Chappell, Richard J., Chen, Yanjun, Clark, Lindsay R, Johnson, Sterling C, Pankow, James S, Walaszek, Art, Soss, Madeleine G   +10 more
openaire   +2 more sources

Progressive Parkinsonism in PPP2R5D‐Related Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT PPP2R5D‐related neurodevelopmental disorder (Houge–Janssens syndrome type 1) is a rare autosomal dominant condition characterized by macrocephaly, intellectual disability, and epilepsy. Progressive parkinsonism is an emerging adult phenotype that neurologists should be aware of since timely genetic diagnosis opens the door to disease‐modifying
Katerina Bernardi, Enrique Gonzalez Saez‐Diez, Joshua Rong, Beril Ay, Shabbir Merchant, Kathryn Yang, Darius Ebrahimi‐Fakhari   +6 more
wiley   +1 more source

Age-related clonal hematopoiesis and HIV infection are associated with geriatric outcomes: The ARCHIVE study

Cell Reports Medicine
Summary: While HIV infection and clonal hematopoiesis (CH) have been linked with inflammatory dysregulation and an increased risk of aging-related comorbidities, their relationship with clinical geriatric syndromes has not been well defined.
Win Min Han, Hossain M.S. Sazzad, Mark Bloch, David A. Baker, Norman Roth, Ellen Bowden-Reid, Don E. Smith, Jennifer F. Hoy, Ian Woolley, Robert Finlayson, David J. Templeton, Gail V. Matthews, Jane Costello, Mark A. Dawson, Sarah-Jane Dawson, Mark N. Polizzotto, Kathy Petoumenos, Paul Yeh, Nila J. Dharan, Win Min Han, Hossain M.S. Sazzad, Mark Bloch, Diana Winter, David Baker, Norman Roth, Helen Lau, Don Smith, Kathryn Acklom, Jennifer F. Hoy, Sally Price, Ian Woolley, Jessica O’Bryan, Robert Finlayson, David J. Templeton, Brett Sinclair, Gail Matthews, Jane Costello, Mark A. Dawson, Sarah-Jane Dawson, Mark N. Polizzotto, Kathy Petoumenos, Paul Yeh, Nila J. Dharan   +42 more
doaj   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source