Results 61 to 70 of about 215,177 (294)

Should Root Plasticity Be a Crop Breeding Target?

Frontiers in Plant Science, 2020
Root phenotypic plasticity has been proposed as a target for the development of more productive crops in variable environments. However, the plasticity of root anatomical and architectural responses to environmental cues is highly complex, and the ...
Hannah M. Schneider, Jonathan P. Lynch
doaj   +1 more source

Adaptive Phenotypic Plasticity Stabilizes Evolution in Fluctuating Environments

Frontiers in Ecology and Evolution, 2021
Fluctuating environmental conditions are ubiquitous in natural systems, and populations have evolved various strategies to cope with such fluctuations. The particular mechanisms that evolve profoundly influence subsequent evolutionary dynamics.
Alexander Lalejini, Alexander Lalejini, Alexander Lalejini, Austin J. Ferguson, Austin J. Ferguson, Austin J. Ferguson, Nkrumah A. Grant, Nkrumah A. Grant, Charles Ofria, Charles Ofria, Charles Ofria   +10 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Fixation of genetic variation and optimization of gene expression: The speed of evolution in isolated lizard populations undergoing Reverse Island Syndrome [PDF]

, 2019
The ecological theory of island biogeography suggests that mainland populations should be more genetically divergent from those on large and distant islands rather than from those on small and close islets.
Aceto, S., Buglione, M., Di Cosmo, A., Fulgione, D., Maselli, V., Petrelli, S., Salvemini, M., Trapanese, M.   +7 more
core   +1 more source

Ecological consequences of phenotypic plasticity [PDF]

Trends in Ecology & Evolution, 2005
Phenotypic plasticity is widespread in nature, and often involves ecologically relevant behavioral, physiological, morphological and life-historical traits. As a result, plasticity alters numerous interactions between organisms and their abiotic and biotic environments.
Miner, Benjamin G, Sultan, Sonia E, Morgan, Steven G, Padilla, Dianna K, Relyea, Rick A   +4 more
openaire   +4 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

The role of forest genetic resources in responding to biotic and abiotic factors in the context of anthropogenic climate change [PDF]

, 2015
The current distribution of forest genetic resources on Earth is the result of a combination of natural processes and human actions. Over time, tree populations have become adapted to their habitats including the local ecological disturbances they face ...
Alfaro, R.I., Baldinelli, G., Dawson, Ian K., El-Kassaby, Y.A., Fady, B., Fleming, R.A., Lindig-Cisneros, R.A., Loo, J., Murdock, T., Navarro, C.M., Saenz-Romero, C., Skroppa, T., Vendramin, G.G., Vinceti, B.   +13 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The relative effects of climatic drivers and phenotypic integration on phenotypic plasticity of a globally invasive plant

Frontiers in Plant Science
IntroductionUnderstanding the constraints of phenotypic plasticity can provide insights into the factors that limit or influence the capacity of an organism to respond to changing environments.
Xincong Chen, Jiayu Wang, Wenwen Liu, Yihui Zhang   +3 more
doaj   +1 more source

Polyploidy as a chromosomal component of stochastic noise: variable scalar multiples of the diploid chromosome complement in the invertebrate species Girardia schubarti from Brazil

Brazilian Journal of Biology, 2017
Chromosome stoichiometry, a form of genetic plasticity, specifically refers to variation in the standard diploid genomic composition of an individual or species.
E. G. F. Benya, A. M. Leal-Zanchet, J. Hauser   +2 more
doaj   +1 more source